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A New study Throws Light On The Growth & Functions Of Insulin Producing Beta Cells

out, these mice developed more severe diabetes. Dr. Kulkarni explained that without the activation of proteins necessary for survival provided by the "knocked-out" receptors, the beta cells became susceptible to cell death as the mice aged.

Dr. Kulkarni's laboratory in the Section on Cellular and Molecular Physiology at Joslin is currently conducting experiments using mice that lack both receptors and exploring what growth factors are altered. He said that it would give them a clue about which growth factors are critical for development of beta cells in the absence of the two receptors.

He said that if they could understand how the beta cells grow, they hope they would be able to think of ways to promote growth that would ultimately aid in diabetes treatment. He explained that if the exact growth factor is identified, that could then be used to promote beta cell growth. He also stated that another treatment option would probably be to grow beta cells outside the body and transplanting them into patients with type 1 or type 2 diabetes.
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