Navigation Links
A New drug Developed To Fight The Bio-Terrorism Threat Of VEE Virus

A new drug is being developed that would reduce the bio-terrorism threat of the Venezuelan equine encephalitis virus. //

Biomedical researchers at the University of Texas Medical Branch at Galveston (UTMB) have announced to start the initial step in the development of effective drug therapies against Venezuelan Equine Encephalitis (VEE) virus, which is a potential bio-terrorist weapon. They claim to have determined the specific structure of a protein that the virus requires for replication.

The virus was developed into a biological weapon during the Cold War by both the United States and the Soviet Union; this has further fuelled fears by experts on the potential of VEE to be developed as a weapon of bio-terrorism. Reports have also indicated sporadic outbreaks of the mosquito-borne VEE virus periodically ravage Central and South America, that had caused infections to tens of thousands of people and killing hundreds of thousands of horses, donkeys and mules.

The protein the scientists focused on is known as the nsP2 protease. It acts like a pair of molecular scissors, chopping another complex of VEE proteins into specific smaller protein molecules that work together to transform living cells into VEE virus factories. "This protein is crucial to VEE virus replication, and we want to create drugs that will turn off such proteins," said Stanley W. Watowich, senior author of a paper on the research to be published in the September 12 issue of the journal Structure. The UTMB associate professor of biochemistry and molecular biology added, "Now that we know what this protease looks like, we can begin a systematic computer-based search for compounds that will inhibit its activity, stop the virus from multiplying in infected individuals, and prevent VEE outbreaks from spreading."

VEE protease inhibitors would function much like the protease inhibitors taken by people infected with HIV, Watowich said, but since human and equine immune systems could quickly overwhelm VEE viruses that were unable to replicate, infections would be eliminated instead of merely controlled, and permanent use of the medication would be unnecessary. (Those infected would also acquire immunity to VEE, just as if they had been vaccinated with a weakened form of the virus.)

Potential therapeutic compounds could be available for pre-clinical studies within two years, according to Watowich, thanks to collaborations with powerful computer centers at the University of Texas at Austin and IBM that will be able to take the UTMB protease structure and sift through "libraries" of millions of molecules, looking for those with the right structural and chemical characteristics to keep the "scissors" from closing.

To produce a detailed enough structure to begin this drug search, lead author and Watowich lab postdoctoral fellow Andrew Russo used X-ray crystallography, in which X-rays are used to scan crystallized protein samples, working both with equipment at UTMB and the high power synchrotron radiation source at Louisiana State University's Center for Advanced Microstructures and Devices in Baton Rouge. "It took about a year of hard work by Andrew, but it was worth it," Watowich said. "In the future when we're dealing with one of these periodic VEE outbreaks or a bioterrorist attack, it will be a very good thing if we have an effective medicine in the cabinet ready to use."

Source-Eurekalert
VIK
'"/>




Related medicine news :

1. Scientists Developed Map For Brain Molecular Communities
2. Scientists Developed Cheap Way To Assess Sleep
3. Diabetic Friendly Egg Developed In India
4. Three In One Ultrasound Probe For 3-D Imaging Of Heart And Tissue Destruction Developed
5. Cervical Cancer Vaccine To Be Developed In India
6. Anti-Microbial Coating For Use Over Biomedical Devices Developed
7. Cure for Osteoarthritis To Be Developed
8. Mice With Human Thought Processes Could Be Developed In The Future
9. Viagra Pill For Women To Be Developed
10. Male Contraceptive Pill Being Developed By Berlin Pharmaceutical
11. New Fertility Predictor Test Developed
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/5/2016)... ... , ... LELO has discovered many people are insecure about their ... email, social media and on the Volonté blog seeking advice about how to actually ... or ‘correct’?” , While some methods are more common than others, there is no ...
(Date:5/5/2016)... ... May 05, 2016 , ... Every year 220 ... heartfelt wishes of these children. The wishes provide hope and motivation through ... CEO of Make-A-Wish Mississippi, Brent Wilson said, “In 2016, the organization will grant ...
(Date:5/5/2016)... Portland, Oregon (PRWEB) , ... May 05, 2016 ... ... the Student American Chiropractic Association (SACA) is slated to host the 2016 National ... chance for all current SACA national officers and chapter officers to come together ...
(Date:5/5/2016)... ... May 05, 2016 , ... Tim Dieter ... serving families of greater Dubuque, IA. The current campaign fundraises for Veteran’s Freedom ... veterans. Donations to Veteran’s Freedom Center may now be made here: http://www.veteransfreedomcenter.com/donate/ ...
(Date:5/5/2016)... ... May 05, 2016 , ... ... for veterinary professionals across the United States. The whole food nutrient solutions company ... patients and giving dog, cat and horse owners’ peace of mind. With the ...
Breaking Medicine News(10 mins):
(Date:5/5/2016)... ORANGE COUNTY, Calif. , May 5, 2016 ... for nearly a decade due to concerns that ... advances in the approach to imaging, as well ... in a new era of medical peripherals that ... better care.   Ampronix  advanced medical imaging is a ...
(Date:5/5/2016)... 2016 Research ... the  "Europe Thrombocytopenia Market and Competitive ... their offering.       (Logo: ... latest research Europe Thrombocytopenia Market and ... comprehensive insights into Thrombocytopenia pipeline products, ...
(Date:5/4/2016)... , May 4, 2016 ... Market Research entitled "Brain Computer Interface Market - Global Industry ... 2024," the  global brain computer interface (BCI) market  is expected ... The market is estimated to expand at a CAGR ... to 2024. A BCI device provides collaboration ...
Breaking Medicine Technology: