Navigation Links
A New Way to Treat Colon Cancer?

Researchers at University of Utah’s Huntsman Cancer Institute have discovered a new target for possible future colon cancer treatments – a molecule that is implicated in 85 percent of colon cancer cases. //

By knocking out – that is, genetically disabling – a molecule called C-Terminal Binding Protein (CTBP) researchers were able to rescue zebrafish from the effects of a mutation in the adenomatous polyposis coli (APC) gene.

In humans, mutations in this gene long have been known to initiate a series of events that cause colon polyps, which eventually become cancerous. APC mutations play a role in 85 percent of colon cancers. The new findings mean CTBP also is involved in that proportion of colon cancers.

In zebrafish, APC mutations keep the intestine from developing properly. “In essence, knocking out CTPB promotes normal development of the intestine in zebrafish carrying an APC mutation,” says David A. Jones, a University of Utah associate professor of oncological sciences and leader of the study.

In normal cells of both humans and zebrafish, the APC gene controls the amount of CTBP present by marking it for destruction. In tumor cells with mutated APC, CTPB is not destroyed; instead it accumulates in the cell.

One function of CTBP is to turn off the process that converts vitamin A into retinoic acid in the cell. Retinoic acid is essential in cell differentiation – the function that determines what type of cell forms and how long it lives. This study observed that in both zebrafish and human tissues with APC mutations, there are high CTBP levels and low capability to produce retinoic acid. In APC-mutated tissues in which CTBP had been “knocked out,” retinoic acid production was restored.

Earlier studies in Jones’ lab showed that lack of retinoic acid caused zebrafish intestines to form incorrectly, and that adding retinoic acid corrected the problems.

"Knocking out CTBP does exactly the same thing, and the logical conclusion is that it’s because CTBP controls retinoic acid production,” says Jones. “Since CTBP is a completely new target, we must now look for potential chemical agents that would work to block its actions. That could take three to five years.”

Source-Neswise
SRM
'"/>




Related medicine news :

1. Advances in Treatment of Cataracts
2. Recommendations for Treatment of Blood Pressue
3. New FDA Approved Drug To Treat Migraine
4. Treatment for Menieres disease
5. Treatment for pre-menstrual syndrome is ineffective
6. Angiotensin-II-receptor blockers - Treat kidney failure
7. Cipro Has Cheaper Cousins to Treat Anthrax
8. Better Treatment for obesity
9. Gene Treatment for Heart Disease
10. Cyclosporin A Treats Leukemia Complications
11. New Way To Treat Lupus
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/17/2017)... ... February 17, 2017 , ... Pharmica Consulting ... on all facets of clinical trial planning and management. Pharmica discussed the importance ... more. In addition, attendees stopping by Pharmica’s booth were able to demo its ...
(Date:2/17/2017)... ... February 17, 2017 , ... Cancer diagnostics workflow ... Tri-Conference February 20 – 22 in San Francisco. As part of the Tri-Conference ... molecular pathology workflow solution, as well as its new precision medicine platform, “Crosswalk ...
(Date:2/17/2017)... ... ... Top neuroendocrine cancer doctors, nurses and specialists from around the world will ... in Beaver Creek, CO. It was announced today by Cindy Lovelace, executive director of ... hosting over 60 faculty members and addressing unmet needs of the NET community. ...
(Date:2/17/2017)... , ... February 17, 2017 , ... ... financial planning assistance to families and business owners in the greater Fort Lauderdale ... Families organization. , For more than 30 years, LifeNet 4 Families has ...
(Date:2/16/2017)... ... February 17, 2017 , ... For some cancer survivors, ... final treatments. Physician researchers at The Marcus Institute of Integrative Health at ... efficacy in reducing symptoms of traumatic stress in cancer patients and published ...
Breaking Medicine News(10 mins):
(Date:2/17/2017)... February 17, 2017 On Thursday, ... 500 edged lower at the closing bell, while the ... the 20,000 benchmark. Moreover, five out of nine sectors ... consideration yesterday,s market sentiment, Stock-Callers.com assessed the following Medical ... PLC (NYSE: SNN ), ABIOMED Inc. (NASDAQ: ...
(Date:2/16/2017)... 2017 DaVita Inc. (NYSE: DVA ) ... 31, 2016. Net income attributable to DaVita ... was $158 million, or $0.80 per share and $880 million, ... income attributable to DaVita Inc. for the quarter and year ... was $192 million, or $0.98 per share, and $789 million, ...
(Date:2/16/2017)... Scripts (NASDAQ: ESRX ) was recognized today by Fortune ... Health Care: Pharmacy and Other Services category. "Express Scripts ... Companies," said Tim Wentworth , CEO and President, Express Scripts. ... 26,000 employees to make medicine more affordable and accessible for the ... ...
Breaking Medicine Technology: