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A New Study Throws Limelight in HIV Vaccine Production

an HIV vaccine, says Brumme, who is now with the Partners AIDS Research Center at MGH.

Data were collected from the British Columbia HOMER cohort, a large group of chronically HIV-infected, treatment-nave individuals for whom HLA class-1 typing and HIV RNA genotyping were performed. Microsoft Research provided personnel and advanced software tools to perform highly sophisticated statistical analysis.

Algorithms developed by David Heckerman, lead researcher of the Machine Learning and Applied Statistics Group at Microsoft Research and study co-author, and his team allowed for more in-depth analysis of the data sets.

We created the software tools to help researchers exploit the power of computing to more quickly and accurately identify the crucial elements of an effective HIV vaccine, said Heckerman.

The original idea for the development of these statistical methods came from Dr. Bette Korber at Los Alamos National Laboratory. Korber and co-researchers Dr. Tanmoy Bhattacharya and Marcus Daniels worked with Heckerman in further developing the cutting-edge statistical approach.

Study results demonstrate that population-based approaches could complement smaller functional studies by providing a whole-gene or whole-virus picture of immune escape. Previous B.C. Centre research published in The Journal of Infectious Diseases investigated the role of HLA class 1 variation on response to anti-HIV therapy.

Moving forward, well be expanding our genetic research to other HIV genes. Well also be investigating the role of drug therapy, says Harrigan.


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