Navigation Links
A New Signaling Mechanism in Drosophila

A new signalling mechanism among cells in the fruit fly, Drosophila melanogaster has been identified by investigators from the Institute of Research in Biomedicine (IRB Barcelona).

The researchers found that two independent groups of cells generate the same signal by different pathways and that these cells subsequently act together to send the signal to the target cell. In this manner, the receptor cell receives the signal from two distinct sources.

Jordi Casanova (IRB Barcelona/CSIC) explains that different types of cells working together to send a message can be regarded as a security measure designed to ensure that the signal reaches the receptor cell in the proper fashion, neither too weakly nor too strongly.

Using RNA interference techniques (RNAi), the researchers observed that it was necessary to disactivate the signal in both groups of cells in order to prevent the message from being sent. They also observed that overstimulating signal production (producing more of the signalling molecule) created problems in the receptor cell, causing it to develop incorrectly.

Researchers made the discovery by studying the behaviour of a gene called torso-like during the early stages of embryonic development of the Drosophila fly. Two groups of cells activated the same torso-like gene separately and by different mechanisms when they were still in separate compartments inside the Drosophila ovary. Subsequently, the cells migrated until they met and jointly signalled the target cell.

Marc Furriols, lead author of the study, explains that the torso-like gene activates a membrane receptor molecule that is specific to Drosophila, but that the molecule belongs to a receptor family (that includes, for example, the human growth factor), which also reacts when it receives an external signal.

This research describes a very signalling mechanism in the fly which is very basic. It gives us good insight into how thes e mechanisms work so that we can later manipulate and control them.

Many of these pathways and signalling systems have been observed throughout evolution and hence, studies with models such as the fruit fly, can provide further insight into how these signalling mechanisms work in humans.


'"/>




Related medicine news :

1. Chemical Signaling Helps Regulate Sensory Map Formation In The Brain
2. Hh Signaling May Play Role In Fat Formation
3. Birth Defects Caused By Deficiencies In Cell Signaling Pathway
4. Key Signaling Switch Identified in Allergic Disease
5. Lake Superior in US Losing Ice Cover Fast, Signaling Global Warming
6. Scientists Report New Take on Sexual Signaling
7. Key Signaling Molecules in New Teeth Formation Identified
8. Scientists Unveil Mechanism Behind Resistance to Severe Malaria
9. New Gene Silencing Mechanism To Prevent Cancer
10. Molecular Mechanism Of HIV Infecting The Healthy Cells Discovered.
11. Self-defense Mechanism of food borne bugs found
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/28/2016)... ... 28, 2016 , ... May 26, 2016- In search of the K. Warriors, ... event of “K Warriors” on June 4, 2016 at Ashbury Hotel and Suites 600 ... sponsored and hosted by Shaolin Institute and sanctioned by KSF (Kungfu Sanda Federation), This ...
(Date:5/28/2016)... , ... May 28, 2016 , ... In a part of the city where’s it’s ... new farm-to-table Kelowna restaurants is hoping to attract diners with a taste for ... Suites officially opened the doors to Cornerstone Grill, an urban casual restaurant focusing on ...
(Date:5/27/2016)... ... May 27, 2016 , ... Southland Log Homes , designer ... timber frame barn kits, which can be found on its website at SouthlandLogHomes.com. , ... barn plans, and they highlight the craftsmanship of timber post and beam construction. ...
(Date:5/27/2016)... ... May 27, 2016 , ... W.S. Badger Co. ... today that it has been recognized as one of the best small businesses for ... named as one of nine small businesses providing progressive benefits to new parents on ...
(Date:5/27/2016)... ... May 27, 2016 , ... With over 60 percent ... the demand for a sustainable product to aid in the rehabilitation process has steadily ... the recovery of individuals with hemiplegia due to stroke. , Ekso Bionics has now ...
Breaking Medicine News(10 mins):
(Date:5/25/2016)... SPRINGS, Florida , May 25, 2016 ... Business Conference & Expo earlier this month, the numbers ... As revenues continue to climb into the billions, more ... the newly released 4th Edition State of Legal Marijuana ... Frontier, a cannabis-focused data-analysis firm, much of the increase ...
(Date:5/25/2016)... , May 25, 2016 Digital Health ... to it by the US Patent and Trademark ... technology includes proprietary processes for electronic opt-­in and ... and wellness programs, HIPAA compliance and otherwise. ... "Our technology allows for ...
(Date:5/25/2016)... , May 25, 2016 ... the precision of circulating tumour DNA (ctDNA) analysis ... the appointment of Professor Clive Morris ... leadership across the clinical development programme, scientific collaborations, ... help deliver significant improvements in clinical outcomes for ...
Breaking Medicine Technology: