Navigation Links
A New Signaling Mechanism in Drosophila

A new signalling mechanism among cells in the fruit fly, Drosophila melanogaster has been identified by investigators from the Institute of Research in Biomedicine (IRB Barcelona).

The researchers found that two independent groups of cells generate the same signal by different pathways and that these cells subsequently act together to send the signal to the target cell. In this manner, the receptor cell receives the signal from two distinct sources.

Jordi Casanova (IRB Barcelona/CSIC) explains that different types of cells working together to send a message can be regarded as a security measure designed to ensure that the signal reaches the receptor cell in the proper fashion, neither too weakly nor too strongly.

Using RNA interference techniques (RNAi), the researchers observed that it was necessary to disactivate the signal in both groups of cells in order to prevent the message from being sent. They also observed that overstimulating signal production (producing more of the signalling molecule) created problems in the receptor cell, causing it to develop incorrectly.

Researchers made the discovery by studying the behaviour of a gene called torso-like during the early stages of embryonic development of the Drosophila fly. Two groups of cells activated the same torso-like gene separately and by different mechanisms when they were still in separate compartments inside the Drosophila ovary. Subsequently, the cells migrated until they met and jointly signalled the target cell.

Marc Furriols, lead author of the study, explains that the torso-like gene activates a membrane receptor molecule that is specific to Drosophila, but that the molecule belongs to a receptor family (that includes, for example, the human growth factor), which also reacts when it receives an external signal.

This research describes a very signalling mechanism in the fly which is very basic. It gives us good insight into how thes e mechanisms work so that we can later manipulate and control them.

Many of these pathways and signalling systems have been observed throughout evolution and hence, studies with models such as the fruit fly, can provide further insight into how these signalling mechanisms work in humans.


'"/>




Related medicine news :

1. Chemical Signaling Helps Regulate Sensory Map Formation In The Brain
2. Hh Signaling May Play Role In Fat Formation
3. Birth Defects Caused By Deficiencies In Cell Signaling Pathway
4. Key Signaling Switch Identified in Allergic Disease
5. Lake Superior in US Losing Ice Cover Fast, Signaling Global Warming
6. Scientists Report New Take on Sexual Signaling
7. Key Signaling Molecules in New Teeth Formation Identified
8. Scientists Unveil Mechanism Behind Resistance to Severe Malaria
9. New Gene Silencing Mechanism To Prevent Cancer
10. Molecular Mechanism Of HIV Infecting The Healthy Cells Discovered.
11. Self-defense Mechanism of food borne bugs found
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/12/2017)... ... ... Asante, a nationally recognized health system in southern Oregon, ... health joint venture through an agreement, effective October 1, 2017, to create AccentCare ... company with Asante, delivering clinically integrated care, for the past eight years. This ...
(Date:10/12/2017)... ... 12, 2017 , ... Dr. Parsa Mohebi, the Los Angeles ... to the newly revamped Cosmetic Town journal section, featuring articles written ... known as Follicular Unit Extraction (FUE). , Dr. Mohebi says “I ...
(Date:10/12/2017)... Washington, D.C. (PRWEB) , ... October 12, 2017 , ... ... of their peers in Washington, D.C., for the 49th Congress of the International ... Ph.D ., Vice President of the Center for Cancer and Blood Disorders ...
(Date:10/12/2017)... ... October 12, 2017 , ... Women-owned ... Michigan’s 2017 Best and Brightest in Wellness® by Best and Brightest. OnSite Wellness ... on Friday, Oct. 20 from 7:30 a.m. to 2 p.m. at the Henry ...
(Date:10/12/2017)... ... October 12, 2017 , ... In the United States, single-family ... some states—like New York, New Jersey, Massachusetts, Texas, Virginia, Connecticut, and California—the average ... extremely low property-tax rates, which contributes to the relatively lower cost of living ...
Breaking Medicine News(10 mins):
(Date:10/10/2017)... Calif. , Oct. 10, 2017  NDS received FDA 510(k) ... — a medical-grade battery-powered display stand specifically designed for endoscopy environments. ... transform technology into a clinical solution to support the improvement of ... Innovative Design ... Mobile Wireless Solution ...
(Date:10/5/2017)... 5, 2017  In response to the nationwide ... Maxillofacial Surgeons (AAOMS) released prescribing recommendations that urge ... used as a first-line therapy to manage a ... Recognizing the value and importance ... "Opioid Prescribing: Acute and Postoperative Pain Management" stresses ...
(Date:10/4/2017)... Oct. 4, 2017 OBP Medical ... illuminating medical devices, today announced regulatory approval from ... Agency (or Agência Nacional de Vigilância Sanitária (ANVISA)) ... cordless surgical retractor with integrated LED light source ... illumination and exposure of a tissue pocket or ...
Breaking Medicine Technology: