Navigation Links
A New Approach In Treatment Neurogenic Detrusor Overactivity In Children

Many reports have dealt with the outcome of botulinum-a toxin (BTX-A) detrusor injections in patients with neurogenic or nonneurogenic detrusor overactivity. BTX-A detrusor injections have been described in adult// patients with neurogenic detrusor overactivity due to spinal cord injury.

Researchers from Germany were able to carry out the same experiments successfully in children with a neurogenic bladder. After many reports of this “wonder drug,” several questions have arisen, including what this injection treatment means for neurourologic patients in the longer term; whether bladder function changes after repeated BTX-A injections, and whether this procedure has a proper place in the treatment algorithm of young patients with neurogenic bladder. In an extension of their previous studies, the authors, set out o assess the long-term success of treatment with repeated botulinum-A toxin (BTX-A; Botox) injections into the detrusor muscle for neurogenic detrusor overactivity in children.

In their study published in the October issue of Urology, the researchers reviewed the charts of 10 children (average age at first injection 11.2 years) with neurogenic detrusor overactivity who had received at least three BTX-A detrusor injections; four had received five or more injections. The total dose of BTX-A was 85 to 300 U. They measured the urodynamic outcomes 6 months after each injection and compared the results after the first injection with the results after the third and fifth injections (in the children who had five or more injections).

The relative changes - each in comparison with the value before injection therapy - after the first versus the fifth injection were as follows: the reflex volume increased by 81% versus 88%, maximal detrusor pressure decreased by 7% versus 39%, maximal cystometric bladder capacity increased by 88% versus 72%, and bladder compliance showed no change at the 6-month follow-up visit after the first injection a nd an increase of 109% after the fifth injection. The results after the third injection were generally similar to those after the fifth injection. No major side effects occurred.

Patients with difficult bladder conditions refractory to anticholinergic drugs have traditionally undergone immediate surgical procedures, such as bladder augmentation. However, according to this new study, BTX-A detrusor injection offers a reliable alternative and protects some of those difficult-to-treat patients for years.

Related medicine news :

1. New Dietary Approach To Manage Kidney Stones
2. Approaching through Telemedicine benefits patients
3. Gel Offers A More Targeted Approach
4. New Cost Effective Approach To Promote Sun Protection
5. Treatment Of Brain Aneurysms By A New Non-Surgical Approach
6. A New Diagnostic Approach To Pediatric Interstitial Lung Disease
7. Lazy Eye Can Be Effectively Treated By New Approach
8. Novel Approach to Identify Protein Links with Genetic Disorder
9. NHS To Be Reformed By Using A Hybrid Approach
10. Two-In One Approach To Prevent Incontinence After Prolapse Surgery
11. Women Afflicted With Dry Eyes As They Approach Menopause
Post Your Comments:

(Date:11/25/2015)... Nairobi (PRWEB) , ... November 26, 2015 , ... ... African Union Commission (AUC), European Union (EU), ANDI Pan African Centres of Excellence, ... Nations Office in Nairobi (UNON) for the opening of the 5th African Network ...
(Date:11/25/2015)... ... November 25, 2015 , ... Lakeview Health, a Jacksonville-based ... celebrate their sobriety and show through pictures what a positive difference it makes. ... Thanksgiving with the hashtag #FacesOfGratitude on their Facebook, Twitter, and Instagram accounts. ...
(Date:11/25/2015)... Crystal Lake, IL (PRWEB) , ... November 25, 2015 , ... ... pleased to announce a recent successful appellate decision obtained by Attorneys Francisco J. Botto ... the case Adcock v. Illinois Workers’ Compensation Comm’n, 2015 IL App (2d) 130884WC. , ...
(Date:11/25/2015)... ... , ... Beddit® has launched a new Android app for use ... a more intuitive SleepScore™ that rates sleep quality on a 100-point scale and makes ... by a proprietary algorithm. Beddit analyzes the data to provide an easy to understand ...
(Date:11/25/2015)... ... November 25, 2015 , ... Today, Mothers Against Drunk Driving ... dropped below 10,000 for the first time since 2011. In 2014, there were 9,967 ... data released by the National Highway Traffic Safety Administration (NHTSA), 32,675 people were killed ...
Breaking Medicine News(10 mins):
(Date:11/25/2015)... , Nov. 25, 2015  Linden Care, LLC, ... optimizing treatment outcomes for patients suffering from chronic pain, ... for a Temporary Restraining Order (TRO) enjoining Express Scripts ... two companies. --> --> ... all of its legal options. --> ...
(Date:11/25/2015)... AVIV, Israel , November 25, 2015 ... (NASDAQ: KTOV ) (TASE: KTOV), a biopharmaceutical company ... simultaneous treatment of various clinical conditions, today announced the ... 3,158,900 American Depository Shares ( ADSs ), each representing ... purchase up to 3,158,900 ADSs. The ADSs and warrants ...
(Date:11/25/2015)... DUBLIN , Nov. 25, 2015 Endo International ... Rajiv De Silva , President and CEO, will discuss ... Healthcare Conference in New York on ... . Click on Investor Relations, and then the ... prior to the presentation,s start time to visit the site ...
Breaking Medicine Technology: