Navigation Links
A Mushroom Extract May Impact the Body’s Immune Syste

Can the extract of a mushroom that is commonly found in the woods of North America, Asia and Europe have a beneficial impact// on the human immune system? A small study using “Turkey Tail” mushroom (Trametes versicolor) extract, has found that it may.

The “Turkey Tail” mushroom is too tough to eat, but it may be ingested in the form of liquid or powdered extracts. One such extract produced by Kureha, Inc., Tokyo, Japan, is Polysaccharide Krestin? (PSK), a protein-bound polysaccharide fraction. The PSK extract has been found to have a beneficial effect in the treatment of certain types of cancers, especially when used in conjunction with chemotherapy. In order to determine its effects on the human immune system, a team of researchers sought to use a proteomic approach to identify the immunologically relevant proteins stimulated by treatment with the mushroom extract in human immune cells.

The team will present preliminary findings during the 21st Annual Meeting of the American Association of Naturopathic Physicians (http://www.Naturopathic.org), being held August 9-12, 2006, at the Oregon Convention Center, Portland, OR.

Methodology Immune cells were isolated from blood taken from nine healthy human volunteers and were cultured in vitro. The immune cell samples were treated under three different conditions: one set with no treatment, which served as the negative control; another set treated with the PSK mushroom extract; a third set treated with phytohemagluttin (PHA), a mitogen known to stimulate activation of immune cells; and a final set treated with both the mitogen and mushroom extract, in combination. Separate portions of cell lysates and supernatants (the liquid medium in which the cells were cultured) were collected at 0, 1 and 24 hours, flash-frozen, and stored at –80°C. Samples were analyzed at pH3 on immobilized metal affinity capture (IMAC30) ProteinChip? arrays, using both low-performance and high-performance mass sp ectrometry (MS). Statistical analyses of low- and high-resolution MS data were cross-validated to determine whether changes in immunologically relevant proteins occurred that were attributable to treatment with the mushroom extract.

Results Statistical analysis of the spectra showed significant differential post-translational modification or expression of proteins, in the range of 1-30 kilodalton (kDa – a unit of measure of the atomic mass of the proteins), in the treated sets of cell cultures, as compared to untreated, negative control samples. Many immunologically relevant proteins, including many known to regulate immune responses, fall within the 1-30 kDa range.

Conclusions The findings from this research study suggest that protein-bound, polysaccharide-rich fractions of Trametes versicolor PSK may modulate the post-translational modification or expression of proteins in healthy human immune cells. The next step is to extract and sequence the proteins of interest to determine their specific function in immune cells. The results invite further research to determine how selected extracts of medicinal mushrooms may be effective in strengthening the body’s immune system against diseases, such as cancer.

(Source: Newwise)
'"/>




Related medicine news :

1. Mushroom and muscle loss
2. Mushrooms can help fight chronic disease
3. Mushroom found to contain powerful antibiotic
4. Mushroom found to be a source of a new antibiotic: Plectasin
5. Novel Vitamin D source in Mushrooms!
6. Mushrooms are Rich Source of Antioxidants
7. Four of Family Died After Consuming Poisonous Mushrooms
8. Mushroom Extract Protects Poultry From Parasite Diseases
9. Magic Mushrooms Treat Obsessive Compulsion Disorder
10. Private Health-care Clinics Mushroom in Ontario
11. Much Room for Cancer Cure in a Mushroom, Scientists Promise
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/22/2017)... ... May 22, 2017 , ... OSF ... group investing in InsightRX, an early stage company in San Francisco that has ... characteristics. Greatpoint Ventures Innovation Fund acted as the lead investor in ...
(Date:5/21/2017)... ... May 20, 2017 , ... GetLinked® ... Services and financial systems. , Dozens of clubs using ABC Financial Services ... processed through GetLinked into their club’s accounting system , The latest implementation is ...
(Date:5/21/2017)... ... May 21, 2017 , ... For the past ... group of scholars, policymakers, and activists wanting to address equity issues in breastfeeding, ... the third book from a recent series of from this conference. , ...
(Date:5/21/2017)... PA (PRWEB) , ... May 21, 2017 , ... Following ... 2012, New York became the first state to require that hospitals follow a protocol ... controversy in the medical community as to whether such steps would have saved Rory ...
(Date:5/19/2017)... Charlotte, NC (PRWEB) , ... May 19, 2017 ... ... of the Charlotte health community, Queens University of Charlotte recently began recruitment efforts ... The program’s curriculum arms students with the skills, knowledge and expertise to approach ...
Breaking Medicine News(10 mins):
(Date:5/8/2017)... 8, 2017 MACRA replaces the outdated ... for service reimbursement. Black Book Research crowdsource-surveyed 8,845 physician ... 1.       The Market for MIPS Compliance Technology is Booming ... practices with 3 or more clinicians seek to buy ... "Given the magnitude of the changes, the hunt is ...
(Date:5/6/2017)... -- May is Stroke Awareness Month and Omron Healthcare is ... to prevent a stroke: monitor and manage your blood ... Prevention, undetected and uncontrolled hypertension is a leading risk ... in personal heart health technology, recently evolved its mission ... stroke and is advancing a national public education effort ...
(Date:5/4/2017)... May 4, 2017  A recent study published ... Ultraviolet-C light as a means of disinfection ... to reduce bioburden on anesthesia workstations. In the ... high-touch, complex medical equipment surfaces contaminated with three ... "This study further validates the body of ...
Breaking Medicine Technology: