T South western study, 13 volunteers – some with a history of kidney stones and some without – underwent three phases, each lasting one week. Chosen in random order, the phases included: a distilled water or control phase; an orange juice phase; and a lemonade phase. There was a three-week interval between phases.
During each phase, volunteers drank 13 ounces of orange juice, lemonade or distilled water three times a day with meals. They also maintained a low-calcium, low-oxalate diet. Urine and blood samples were taken at intervals during each phase. The study was done at UT South western’s General Clinical Research Center.
Orange juice, researchers found, boosted the levels of citrate in the urine and reduced the crystallization of uric acid and calcium oxalate – the most frequently found ingredient in kidney stones.
But lemonade did not increase the levels of citrate, an important acid neutralizer and inhibitor of kidney stone formation.
'One reason might be the different constituents of various beverages,' Dr. Odvina said.
For instance, the citrate in orange and grapefruit juice is accompanied by a potassium ion while the citrate in lemonade and cranberry juice is accompanied by a hydrogen ion. Ions of hydrogen, but not potassium, counteract the beneficial effects of the high citrate content.
'There is an absolute need to consider the accompanying positive charge [of hydrogen ions] whenever one assesses the citrate content of a diet,' Dr. Odvina said. 'br>
Source-EurekalertBR>VIK
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