Navigation Links
A Gene Associated With Severe Kidney Failure in Diabetes Found

Diabetes is the leading cause of end-stage kidney disease worldwide, an illness that requires either kidney dialysis treatments or a kidney transplant for survival. //

A research team at Wake Forest University Baptist Medical Center and the University of Heidelberg has proven that a gene protects some people with diabetes from developing severe kidney failure or "end-stage renal disease."

The carnosinase 1 gene, located on human chromosome 18, produces the protective factor, said Barry I. Freedman, M.D., the John H. Felts III Professor and head of the Section on Nephrology, in an article in Nephrology Dialysis Transplantation published online.

"This is a major gene that appears to be associated with development of severe diabetic kidney disease," he said.

The research team evaluated 858 subjects, including diabetic patients with end-stage kidney failure on dialysis, diabetic patients with normal kidney function, and healthy non-diabetic individuals. They confirmed that a protective form of the carnosinase 1 gene was present in greater frequency among both healthy individuals and diabetic subjects without kidney disease, compared to the diabetic patients on dialysis who more commonly had forms of the gene that were not protective.

This discovery may lead to novel treatment strategies in susceptible diabetic patients to protect them from kidney failure and may provide a marker to determine which diabetic patients are at increased risk for future kidney disease, Freedman said.

The carnosinase 1 gene produces an enzyme called carnosinase. Carnosinase inactivates the protective substance carnosine. Carnosine appears to prevent scarring from developing in kidney tissue and serves as a scavenger of damaging oxygen-free radicals.

"Prior to these genetic analyses, kidney doctors were unaware that this pathway played an important role in diabetic kidney disease," Freedman said.

He added that the groups at Wake Forest and in Germany had been looking for the gene or genes after concluding that a region on chromosome 18 was important in predisposing people who have type 2 diabetes (adult onset diabetes) to the development of severe kidney failure. Freedman said the actions of this gene apply to Europeans, American whites and Arabs.

When his group repeated the analysis in black Americans, there was no evidence that the carnosinase pathway was involved in their kidney failure.

"It is possible that American blacks have different carnosine metabolism, making them less susceptible to alterations in carnosinase gene activity. Analyses are currently under way," said Freedman. "It is also possible that an additional gene or genes on chromosome 18 is associated with susceptibility to end-stage kidney disease in black Americans, and our group is actively trying to identify them."

Freedman said that among people who are susceptible to kidney failure, "it will be important to evaluate whether the administration of carnosine or agents that inhibit carnosinase activity will protect diabetic individuals from the development of progressive kidney disease."

He said that while carnosine is available over the counter in health food stores, it is possible that excessive carnosinase enzyme activity could prevent carnosine supplementation from protecting the kidney. As such, carnosinase blockers may prove to be more important.

Freedman noted that Wake Forest researchers "have one of the largest existing collections of DNA samples from black and white families with multiple members having end-stage kidney disease. We have been evaluating these families since 1991."

Source-Eurekalert
SRI
'"/>




Related medicine news :

1. Moderate Use of Analgesics - Not Associated With Kidney Dysfunction
2. Bayer Voluntarily Withdraws BAYCOL - A Drug Associated With 50 Deaths
3. Associated therapy for multiple myeloma
4. Associated scan for detecting ovarian cancer spread
5. Ginseng Associated with Pregnancy Risks
6. Enzyme Associated with Memory
7. 3 die, 500 sickened in nations largest hepatitis A outbreak Associated Press
8. Enzyme Associated With Memory
9. Problems Associated With Iron Deficiency
10. Asbestos Exposure Associated With An Increased Risk For Autoimmune Disease
11. Young Patients On Antidepressants Found To Be Associated With Suicidal Tendencies
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... ... October 13, 2017 , ... Ellevate Network, the leading network for professional ... action towards gender equality at their inaugural Summit in New York City in June. ... a social audience of over 3 million. To watch the Mobilize Women video, ...
(Date:10/13/2017)... ... , ... “The Journey: From the Mountains to the Mission Field”: the story ... the Philippines. “The Journey: From the Mountains to the Mission Field” is the creation ... has taught all ages and currently teaches a class of ladies at her church, ...
(Date:10/12/2017)... WAUSAU, Wis. (PRWEB) , ... October 12, 2017 ... ... formulated standard products to meet the demand of today’s consumer and regulatory authorities ... team of probiotic experts and tested to meet the highest standard. , ...
(Date:10/12/2017)... ... 2017 , ... Dr. Parsa Mohebi, the Los Angeles based ... the newly revamped Cosmetic Town journal section, featuring articles written by ... as Follicular Unit Extraction (FUE). , Dr. Mohebi says “I enjoy ...
(Date:10/12/2017)... ... October 12, 2017 , ... Health Literacy Innovations (HLI), ... software tool, and the Cancer Patient Education Network (CPEN), an independent professional organization ... a new strategic alliance. , As CPEN’s strategic partner, HLI will help ...
Breaking Medicine News(10 mins):
(Date:10/10/2017)... Oct. 10, 2017   West Pharmaceutical Services, Inc. ... for injectable drug administration, today shared the results of ... for improving the intradermal administration of polio vaccines. The ... Summit in May 2017 by Dr. Ondrej Mach ... World Health Organization (WHO), and recently published in the ...
(Date:10/4/2017)... Mass. , Oct. 4, 2017 ... of single-use, self-contained, illuminating medical devices, today announced ... National Health Surveillance Agency (or Agência Nacional de ... The first single-use, cordless surgical retractor with integrated ... provides optimal access, illumination and exposure of a ...
(Date:10/2/2017)... COPENHAGEN, Denmark , Oct. 2, 2017 The ... tool in the struggle to reverse the tide of prescription ... plan for regulating their medicine intake and stepping down their ... is set to launch in December 2017; the first 100,000 ... access. Learn more at http://www.rebound-solution.com/ ...
Breaking Medicine Technology: