Navigation Links
A Detail Analysis of Head and Neck Cancer

The discovery of the molecular mechanism behind the aggressive head and neck cancer was unveiled by the researchers at the San Francisco VA Medical Center (SFVAMC). // It is a highly malignant form of cancer with a very high death rate. They have discovered the triple interaction between CD44, hyaluronan (HA), and LARG. CD44 is a surface receptor molecule that plays an important role in a variety of cellular functions. Hyaluronan (HA) is a complex carbohydrate found in the connective tissues between cells. LARG is a signal activator found in tumor cells. The triple interaction results in the initiation of two molecular pathways that simultaneously cause tumor cell growth and tumor cell migration.

Lilly Bourguignon, PhD, a research career scientist at SFVAMC and a professor of medicine at the University of California, San Francisco is the lead author. The study results are reported In Press section of the Journal of Biological Chemistry. Bourguignon and her team found that HA mediates the interaction between CD44 and LARG in a way that stimulates a molecular pathway called RhoA. It causes the tumor cell's cytoskeleton to reorganize such that the tumor cells migrate to other sites in the body, resulting in cancer metastasis. Then the HA-mediated CD44/LARG complex binds with epidermal growth factor receptor (EGFR), located on the tumor cell's surface.

This initiates another molecular pathway called Ras which promotes the growth of the tumor cells. LARG is a central player in these molecular interactions and can be used in the potential treatment that could prevent both pathways from being initiated. Inside the LARG segment there is a PDZ domain which when introduced into the tumor cell, it binds up all available CD44 and EGFR, leaving them unavailable to initiate the deadly twin molecular pathways. In the future, LARG could be utilized as a drug target leading to a new therapeutic strategy. The CD44/EGFR complex can be used as a marker for potenti ally aggressive head-neck tumors. This complex may be used a clinical predictor for evaluating the potential of head and neck cancers to metastasize.


'"/>




Related medicine news :

1. Details Of Heart Failure Discovered
2. Details of Cosmetic Surgery in a Special Website.
3. New Zealand Requests Details from Britain about ‘Black Sheep
4. Molecular Anatomy of Influenza Virus Detailed
5. Mobile Phone and Cancer – A Detailed Study to Understand the Risk
6. Indian Scientists Make Wide-Ranging Analysis And Annotation Of X Chromosome
7. Meta Analysis Links Diabetes And Colorectal Cancer
8. NASA Analysis Say 2005 Was The Warmest Year
9. First Suspected Bird Flu Case In Serbia: Samples Sent For Analysis
10. Analysis: Bowel Diseases Triples Infertility Risks In Women
11. Analysis of Placenta Helps In Diagnosis of Autism At Birth
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... Little Rock, AR (PRWEB) , ... October 13, ... ... owned firm with locations throughout Arkansas that offers insurance and financial preparation services, ... to benefit the Rock City Rescue organization. , Rock City Rescue is a ...
(Date:10/13/2017)... , ... October 13, 2017 , ... ... the certification process to promote standards of excellence for the field of eating ... for March 22 – 25, 2018 in Orlando, Florida at the Omni Resort ...
(Date:10/13/2017)... ... ... Apple Rehab Shelton Lakes , which specializes in the delivery of sub-acute ... of a disaster drill on October 3rd. , Apple Rehab participated with the Shelton ... well as the Connecticut Long Term Care Mutual Aid Plan (LTC-MAP). The LTC-MAP ...
(Date:10/13/2017)... ... October 13, 2017 , ... Global Healthcare Management’s 4th Annual Kids ... Milford, NJ. This free event, sponsored by Global Healthcare Management’s CEO, Jon Letko, ... run is geared towards children of all ages; it is a non-competitive, non-timed event, ...
(Date:10/13/2017)... ... 2017 , ... “The Journey: From the Mountains to the Mission Field”: the ... in the Philippines. “The Journey: From the Mountains to the Mission Field” is the ... She has taught all ages and currently teaches a class of ladies at her ...
Breaking Medicine News(10 mins):
(Date:10/12/2017)... AVACEN Medical , Inc. (AVACEN) announced that Frost & ... Innovation Award for Its fibromyalgia pain management device. The ... market research by Frost & Sullivan,s industry experts. ... product, the AVACEN 100, offers a safe and effective solution ... ...
(Date:10/11/2017)...  Caris Life Sciences ® , a leading innovator ... precision medicine, today announced that St. Jude Medical Center,s ... (POA) as its 17 th member. Through participation ... Cancer Institute will help develop standards of care and ... making cancer treatment more precise and effective. ...
(Date:10/10/2017)... 2017   West Pharmaceutical Services, Inc. (NYSE: ... drug administration, today shared the results of a study ... the intradermal administration of polio vaccines. The study results ... May 2017 by Dr. Ondrej Mach , Clinical ... Organization (WHO), and recently published in the journal ...
Breaking Medicine Technology: