Navigation Links
A Detail Analysis of Head and Neck Cancer

The discovery of the molecular mechanism behind the aggressive head and neck cancer was unveiled by the researchers at the San Francisco VA Medical Center (SFVAMC). // It is a highly malignant form of cancer with a very high death rate. They have discovered the triple interaction between CD44, hyaluronan (HA), and LARG. CD44 is a surface receptor molecule that plays an important role in a variety of cellular functions. Hyaluronan (HA) is a complex carbohydrate found in the connective tissues between cells. LARG is a signal activator found in tumor cells. The triple interaction results in the initiation of two molecular pathways that simultaneously cause tumor cell growth and tumor cell migration.

Lilly Bourguignon, PhD, a research career scientist at SFVAMC and a professor of medicine at the University of California, San Francisco is the lead author. The study results are reported In Press section of the Journal of Biological Chemistry. Bourguignon and her team found that HA mediates the interaction between CD44 and LARG in a way that stimulates a molecular pathway called RhoA. It causes the tumor cell's cytoskeleton to reorganize such that the tumor cells migrate to other sites in the body, resulting in cancer metastasis. Then the HA-mediated CD44/LARG complex binds with epidermal growth factor receptor (EGFR), located on the tumor cell's surface.

This initiates another molecular pathway called Ras which promotes the growth of the tumor cells. LARG is a central player in these molecular interactions and can be used in the potential treatment that could prevent both pathways from being initiated. Inside the LARG segment there is a PDZ domain which when introduced into the tumor cell, it binds up all available CD44 and EGFR, leaving them unavailable to initiate the deadly twin molecular pathways. In the future, LARG could be utilized as a drug target leading to a new therapeutic strategy. The CD44/EGFR complex can be used as a marker for potenti ally aggressive head-neck tumors. This complex may be used a clinical predictor for evaluating the potential of head and neck cancers to metastasize.


Related medicine news :

1. Details Of Heart Failure Discovered
2. Details of Cosmetic Surgery in a Special Website.
3. New Zealand Requests Details from Britain about ‘Black Sheep
4. Molecular Anatomy of Influenza Virus Detailed
5. Mobile Phone and Cancer – A Detailed Study to Understand the Risk
6. Indian Scientists Make Wide-Ranging Analysis And Annotation Of X Chromosome
7. Meta Analysis Links Diabetes And Colorectal Cancer
8. NASA Analysis Say 2005 Was The Warmest Year
9. First Suspected Bird Flu Case In Serbia: Samples Sent For Analysis
10. Analysis: Bowel Diseases Triples Infertility Risks In Women
11. Analysis of Placenta Helps In Diagnosis of Autism At Birth
Post Your Comments:

(Date:6/25/2016)... ... 2016 , ... "With 30 hand-drawn hand gesture animations, FCPX users can easily ... of Pixel Film Studios. , ProHand Cartoon’s package transforms over 1,300 hand-drawn pictures ... . Simply select a ProHand generator and drag it above media or text in ...
(Date:6/25/2016)... ... 2016 , ... Conventional wisdom preaches the benefits of moderation, whether it’s a ... the bar too high can result in disappointment, perhaps even self-loathing. However, those who ... , Research from reveals that behind the tendency to set ...
(Date:6/24/2016)... Dallas, Texas (PRWEB) , ... June 24, 2016 ... ... 12th International Conference and Scientific Sessions in Dallas that it will receive two ... Announcement of the grants came as PHA marked its 25th anniversary by recognizing ...
(Date:6/24/2016)... Plano, TX (PRWEB) , ... June 24, 2016 , ... ... taking part in Genome magazine’s Code Talker Award, an essay contest in which patients ... for an award to be presented at the 2016 National Society of Genetic Counselors ...
(Date:6/24/2016)... ... June 24, 2016 , ... National recruitment firm Slone ... executive with extensive sequencing and genomics experience, as Vice President of North American Capital ... will be responsible for leading the sales team in the commercialization of the HTG ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... N.J. , June 24, 2016  Collagen ... the design, development and manufacturing of collagen and ... regeneration announced today that Bill Messer ... and Marketing to further leverage the growing portfolio ... medical devices. Bill joins the Collagen ...
(Date:6/24/2016)... , June 24, 2016 The Academy ... of recommendations that would allow biopharmaceutical companies ... with entities that make formulary and coverage decisions, a ... "value" of new medicines. The recommendations address ... not appear on the drug label, a prohibition that ...
(Date:6/24/2016)...   Pulmatrix, Inc ., (NASDAQ: PULM ... announced today that it was added to the Russell ... comprehensive set of U.S. and global equity indexes on ... milestone for Pulmatrix," said Chief Executive Officer Robert ... progress in developing drugs for crucial unmet medical needs, ...
Breaking Medicine Technology: