Navigation Links
A Breakthrough in the Study of Hepatitis C

Researchers have devised a novel viral culture system, which makes way for a better study of Hepatitis C virus. This system enables the replication of virus// (isolated from patient) in non-transformed hepatocytes. Systems in vogue involve culture of permissive viral strains in transformed cell lines.

The study report by Lázaro et al, ‘Hepatitis C virus replication in transfected and serum-infected cultured human fetal hepatocytes,’ appears in the February issue of The American Journal of Pathology.

Hepatitis C virus (HCV) infection affects approximately 170,000,000 people worldwide. HCV liver disease, which may induce liver inflammation, cirrhosis, and/or hepatocellular carcinoma, represents the foremost reason for liver transplantation in much of the U.S.

Study of HCV replication within liver cells, or hepatocytes, has been hampered by a lack of adequate virus culture systems. Some systems allow the virus to infect cells but do not permit prolonged replication and production of virus, while other systems rely on derivatives of permissive virus isolates for efficient replication in transformed (mutated) cell lines. Still lacking has been a system to sustain replication of novel virus isolates from patients using nontransformed hepatocytes.

Nelson Fausto of the University of Washington School of Medicine has crossed this hurdle using a human fetal hepatocyte culture system that was previously developed in his lab. Using this system, his group has demonstrated sustained replication and production of virus particles for at least 2 months, with these virus particles able to infect new cells.

In their first experiments, Fausto and colleagues transfected hepatocyte cultures with HCV genomic RNA and found replication of HCV RNA genomes and production of core protein (for virus particle formation). Release of infectious virus particles was confirmed, as media from these cells were able to infect naive hepatocytes.
'"/>




Page: 1 2

Related medicine news :

1. Sperm washing helps couples – Breakthrough in focu
2. ZD1839 Proves Effective - A Breakthrough in fighting Lung Cancer
3. Breakthrough in eye treatment
4. Genetic Breakthrough in Common Eye Problem
5. Breakthrough in cancer therapy
6. Breakthrough in Type II Diabetes
7. Breakthrough In Stem Cell Work
8. A Likely Breakthrough For Prostate Cancer Patients
9. New DNA Breakthrough Can Change Future Of Medicine
10. Breakthrough In New Vaccine For Malaria
11. Medical Breakthrough - Kidney Transplant Recipient Survives Without Drugs
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Breakthrough the Study Hepatitis

(Date:5/23/2015)... 23, 2015 Manufacturers are now required to ... (HSPF) of 8.2. Experts in the field agree that the ... , The HSPF score is what miles per gallon is ... the unit. Although the minimum HSPF score has been raised ... an HSPF score north of 12. Indeed, the regulation was ...
(Date:5/22/2015)... 2015 The world is at ... are intersecting to create new opportunities for leadership ... speaker at WesternU's 34th annual Commencement Exercises said ... Newsom, a former San Francisco mayor and likely ... the graduation ceremony for WesternU's colleges of Allied ...
(Date:5/22/2015)... New York, New York (PRWEB) May 22, 2015 ... ( http://www.xareltolawsuit2015.com/ ) filed on behalf of individuals ... complications due to its use continue to move ... of Louisiana. According to a Pretrial Order dated ... governing the preservation of documents and electronically stored ...
(Date:5/22/2015)... “It’s like learning an new language,” ... President of Clinical Operations/Education and Training at Harmony ... how care is coded and reimbursed.” , Harmony ... reimbursement, operations and compliance consulting, as well as ... a new series of day-long seminars on the ...
(Date:5/22/2015)... According to a new Aegis Living Study on Attitudes Toward ... worry about what will happen to their memory as they ... Generation), which may help explain why nearly half of all ... (47%), Gen X’ers (51%), and Boomers (43%). The study was ... than 2,000 U.S. adults ages 18+. , “This study ...
Breaking Medicine News(10 mins):Health News:Parker & Sons Welcomes the Department of Energy’s Water Heater Regulation 2Health News:Newsom to WesternU Grads: The Future is Inside You 2Health News:Newsom to WesternU Grads: The Future is Inside You 3Health News:Court Overseeing Federal Xarelto Lawsuits Establishes Procedures Governing Preservation of Documents, Electronically Stored Information 2Health News:Court Overseeing Federal Xarelto Lawsuits Establishes Procedures Governing Preservation of Documents, Electronically Stored Information 3Health News:Court Overseeing Federal Xarelto Lawsuits Establishes Procedures Governing Preservation of Documents, Electronically Stored Information 4Health News:Harmony Healthcare International Takes the Lead in Launching ICD-10 Coding Transition in Post-Acute Care 2Health News:Harmony Healthcare International Takes the Lead in Launching ICD-10 Coding Transition in Post-Acute Care 3Health News:New Study Reveals America’s Fear of Aging 2Health News:New Study Reveals America’s Fear of Aging 3
... to bring global attention to exhibitors at San Antonio ... of,Commerce has named the American Dental Association,s (ADA) 2008 ... The ADA Annual,Session is one of only about 36 ... The International Buyer program, a joint effort between ...
... to increased death risk, research shows , TUESDAY, Dec. 4 ... boost your risk of death, British researchers report. , "In ... or eight hours a night is optimal for health," study ... said in a prepared statement. , Her team studied more ...
... resonance imaging machine, the 9.4 Tesla at the University of ... soon offer physicians a real-time view of biological processes in ... the November Journal of Magnetic Resonance Imaging in an issue ... that the 9.4T will usher in a new era of ...
... Calif., Dec. 4 Beckman Coulter,Inc. (NYSE: ... of,products that simplify, automate, and innovate complex biomedical ... and chief,executive officer, will present at the 2007 ... 2007, at 2:30 p.m. (ET)., (Logo: ...
... MedcomSoft(R) Inc., a,provider of the next generation of ... Haveman, a prominent health and human,services expert who ... Bush to,the Iraq Coalition Provisional Authority, has joined ... are drawn from both the,public and private sector ...
... Governor Edward G.,Rendell today said Pennsylvania must ... adults and that it can be done while ... to affordably,practice in the state. The Governor said ... in the Health Care Provider Retention,Account., "Since ...
Cached Medicine News:Health News:U.S. Department of Commerce Selects 2008 ADA Annual Dental Meeting for International Buyer Program 2Health News:World's most powerful MRI ready to scan human brain 2Health News:MedcomSoft appoints former U.S. presidential health advisor, James Haveman, to health Care advisory board 2Health News:MedcomSoft appoints former U.S. presidential health advisor, James Haveman, to health Care advisory board 3Health News:Governor Rendell Says Funds Are Within Reach to Cover the Uninsured, Continue Mcare Abatement Program 2Health News:Governor Rendell Says Funds Are Within Reach to Cover the Uninsured, Continue Mcare Abatement Program 3Health News:Governor Rendell Says Funds Are Within Reach to Cover the Uninsured, Continue Mcare Abatement Program 4
(Date:5/21/2015)... May 21, 2015 ... announced the addition of the "North ... Replacement, Digit Replacement, Elbow Replacement, Hip Replacement, ... 2019" report to their offering. ,     ... replacement was valued at $4,470.9 million in ...
(Date:5/21/2015)... 21, 2015 Research ... the addition of the "Arthroscopy Devices ... ,     (Logo: http://photos.prnewswire.com/prnh/20130307/600769) , ,The purpose of ... the world market for Arthroscopy Devices. The ... impacting the market for these products. , ...
(Date:5/21/2015)... 21, 2015 The Pharmaceutical Care Management ... Medicare Part D offsets included in the Energy ... "If the 21st Century Cures initiative can only ... health program – Medicare – then its costs ... the road. "Leveraging payments to Part ...
Breaking Medicine Technology:North American Joint Reconstruction Market 2015-2019 - Zimmer Holdings, DePuy Synthes Companies, Stryker, Biomet & Smith & Nephew Dominates the $4.4 Billion Market 2Analysing Arthroscopy Devices Markets Worldwide 2014-2020 2Analysing Arthroscopy Devices Markets Worldwide 2014-2020 3
... 22 Congresswoman Debbie,Wasserman Schultz will present a ... Department of Defense to support spinal cord injury ... - a leader in,spinal cord injury research - ... will provide details on STU current support, University,science ...
... independent team of,scientists is leading Alzheimer,s disease research ... grant they received last year from,Alzheimer,s Disease Research, ... Donald F. Weaver, M.D., Ph.D. and his colleagues ... leading a,multi-site, multidisciplinary international effort to design a ...
Cached Medicine Technology:Aiming at Multiple Alzheimer's Proteins May be Key to Success 2Aiming at Multiple Alzheimer's Proteins May be Key to Success 3
... The Johns Hopkins University Dermatology, ... Laboratory is a federally-(Clinical Laboratory Improvement ... that began operation in 1982. Its ... quality diagnostic allergy and immunology testing ...
... a national reference laboratory and a ... offers an extensive test menu of ... in clinical and anatomic pathology. Owned ... Laboratories clients include university teaching hospitals ...
Sharp tipped scissors angled 135 from the shaft with a horizontal cutting action. For cutting in the plane parallel to the retina and cutting membranes adherent to the retinal surface (delamination)....
Disposable Microscissors: Horizontal, Straight...
Medicine Products: