Navigation Links
A Boon to Hearing Impaired-Gene Transfer

Researchers at the University of Virginia Health System have discovered a way to transfer genes, which they hope will restore hearing, into diseased tissue of the human inner ear . This important step brings scientists closer to curing genetic or acquired hearing loss.

Dr. Jeffrey Holt, associate professor of neuroscience and otolaryngology at UVa, and his research team, including Dr. Bradley Kesser, an assistant professor of otolaryngology, targeted a gene known as KCNQ4, which causes genetic hearing loss in humans when mutated. They engineered a correct form of the gene and created a gene therapy delivery system that successfully transferred the KCNQ4 gene into human hair cells harvested from the inner ears of patients with hearing loss.

Our results show that gene therapy reagents are effective in human inner ear tissue. Taken together with the results from another group of scientists who showed that similar gene therapy compounds can produce new hair cells and restore hearing function in guinea pigs suggest that the future of gene therapy in the human inner ear is sound, Holt said.

Hair cells have hair-like projections that line the cochlea. In people with normal hearing, hair cells convert sound into electrical signals, which are ultimately transmitted to the brain. People with hearing loss suffer from too few, damaged or missing hair cells.

Holts past research uncovered the speed at which hair cells develop in mouse embryos, a finding necessary to help researchers learn how to regenerate hair cells. With this current development, Holt and his team could one day restore the hearing process in damaged hair cells.

This is a critically important step forward. We hope this breakthrough will propel the field of hearing and deafness research toward our collective goal of curing genetic and acquired deafness, Holt said.


'"/>




Page: 1

Related medicine news :

1. Hearing loss can be detected by simple screening
2. A High-Definition Hearing Aid that thinks for you
3. Vitamin E Could Restore Sudden Hearing Loss
4. Hearing loss can happen from regular exposure to carbon monoxide
5. Studies On Hearing Loss Discovers New Causes
6. Possibility Of Treatment For Permanent Hearing Loss
7. Hearing Problems Of Middle Age Are Affecting The Younger Generation
8. Researchers Find Out The Cause Of Immune Attacks Behind Hearing Loss
9. Early Screening For Hearing Impairments In Newborn Can Be Helpful
10. Implants In The Ear Is Effective Against All Types Of Hearing Loss
11. Kalam Appeals to Eradicate Hearing Disability
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/8/2016)... ... February 08, 2016 , ... The Federal Laboratory ... federallabs.org . The site houses a wealth of federal resources that businesses can ... process called technology transfer (T2). As a network of over 300 federal laboratories, ...
(Date:2/8/2016)... ... 2016 , ... A man who has struggled to quit smoking, a man who has struggled ... to find solutions to his problems – and he did. Now Nabat, a serial entrepreneur ... introduce his breakthrough inventions to the world and better people's lives. His own experience with ...
(Date:2/8/2016)... ... 08, 2016 , ... The Bell Agency, a full service ... of their ongoing community enrichment program. The current campaign fundraises for Angels & ... now being accepted at: http://www.angelsanddoves.com/donate.html . , Angels & Doves was founded ...
(Date:2/8/2016)... ... February 08, 2016 , ... ... While a significant number of women and men with eating disorders report a ... that best predicts the development of an eating disorder. , At the ...
(Date:2/8/2016)... ... February 08, 2016 , ... TopConsumerReviews.com recently awarded their ... removal products. , Moles are derived from a cluster of melanin when exposed to ... wrong places and create a lifetime of embarrassment. Historically, mole removal has ...
Breaking Medicine News(10 mins):
(Date:2/8/2016)...  Ventana Medical Systems, Inc. (Ventana), a member of ... top oncologists, pathologists, research scientists and healthcare industry ... annual Tucson Symposium March 8-9 to learn about ... in cancer research and treatments that will impact ... Grogan , annually draws more than 500 global ...
(Date:2/8/2016)... -- http://www.researchandmarkets.com/research/fqx6nz/global_skin ) has announced ... Equipment Market 2016-2020" report to their offering. ... announced the addition of the "Global Skin ... offering. --> Research and ... of the "Global Skin Protective Equipment Market ...
(Date:2/8/2016)... , Feb. 8, 2016  A research team led ... has discovered details of how the abnormal breakage and ... particularly aggressive form of acute lymphoblastic leukemia (ALL). Such ... genetic mutations trigger overproduction of immature cells, called lymphoblasts. ... discoveries of the malfunction underlying the type called "Ph-like ...
Breaking Medicine Technology: