Navigation Links
A Boon to Hearing Impaired-Gene Transfer

Researchers at the University of Virginia Health System have discovered a way to transfer genes, which they hope will restore hearing, into diseased tissue of the human inner ear . This important step brings scientists closer to curing genetic or acquired hearing loss.

Dr. Jeffrey Holt, associate professor of neuroscience and otolaryngology at UVa, and his research team, including Dr. Bradley Kesser, an assistant professor of otolaryngology, targeted a gene known as KCNQ4, which causes genetic hearing loss in humans when mutated. They engineered a correct form of the gene and created a gene therapy delivery system that successfully transferred the KCNQ4 gene into human hair cells harvested from the inner ears of patients with hearing loss.

Our results show that gene therapy reagents are effective in human inner ear tissue. Taken together with the results from another group of scientists who showed that similar gene therapy compounds can produce new hair cells and restore hearing function in guinea pigs suggest that the future of gene therapy in the human inner ear is sound, Holt said.

Hair cells have hair-like projections that line the cochlea. In people with normal hearing, hair cells convert sound into electrical signals, which are ultimately transmitted to the brain. People with hearing loss suffer from too few, damaged or missing hair cells.

Holts past research uncovered the speed at which hair cells develop in mouse embryos, a finding necessary to help researchers learn how to regenerate hair cells. With this current development, Holt and his team could one day restore the hearing process in damaged hair cells.

This is a critically important step forward. We hope this breakthrough will propel the field of hearing and deafness research toward our collective goal of curing genetic and acquired deafness, Holt said.


'"/>




Page: 1

Related medicine news :

1. Hearing loss can be detected by simple screening
2. A High-Definition Hearing Aid that thinks for you
3. Vitamin E Could Restore Sudden Hearing Loss
4. Hearing loss can happen from regular exposure to carbon monoxide
5. Studies On Hearing Loss Discovers New Causes
6. Possibility Of Treatment For Permanent Hearing Loss
7. Hearing Problems Of Middle Age Are Affecting The Younger Generation
8. Researchers Find Out The Cause Of Immune Attacks Behind Hearing Loss
9. Early Screening For Hearing Impairments In Newborn Can Be Helpful
10. Implants In The Ear Is Effective Against All Types Of Hearing Loss
11. Kalam Appeals to Eradicate Hearing Disability
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/20/2017)... ... ... A new partnership between Goodwill® and Roadie, Inc. aims to make it ... to couches to dressers and bicycles. Roadie — the national on-the-way delivery network — ... center through February 28th. , “January is an exciting time when resolutions are ...
(Date:1/20/2017)... , ... January 20, 2017 , ... Bionic Sports Nutrition ... walks of life, announced it had a successful January ECRM Trade Show in Hilton ... the United States, which allows it to provide its products to all clients at ...
(Date:1/20/2017)... raton florida (PRWEB) , ... January 20, 2017 , ... ... at the Dana Farber Cancer Institute. For Betsy, the clinical trial has been ... her cancer has not worsened. , Betsy Brauser was diagnosed with ovarian cancer ...
(Date:1/20/2017)... (PRWEB) , ... January 20, 2017 , ... “The Angel”: ... the Lord has set out for each of his children. “The Angel” is the ... School of Music in New York City, and impassioned writer. , When asked of ...
(Date:1/20/2017)... ... January 20, 2017 , ... “Christmas in Suffolk”: a ... author, Sara Seymour, who lives in Lafayette, Indiana where she works in a daycare ... coffees and writes. , Published by Christian Faith Publishing, Sara Seymour’s new book is ...
Breaking Medicine News(10 mins):
(Date:1/21/2017)... , Jan. 20, 2017  Today, ... Symposia Conference, "PI3K Pathways in Immunology, Growth ... (NASDAQ: INFI ) presented ... development candidate that selectively inhibits phosphoinositide-3-kinase-gamma (PI3K-gamma). ... to help overcome resistance to checkpoint inhibition ...
(Date:1/20/2017)... CINCINNATI , Jan. 20, 2017 /PRNewswire/ ... has acquired Megadyne Medical Products, Inc., a ... manufactures and markets electrosurgical tools used in ... the intelligence of Ethicon,s* advanced energy devices ... representing a major step forward in Ethicon,s ...
(Date:1/20/2017)... January 20, 2017 ... an Nothilfe   Die internationale humanitäre Stadt soll ... zu schaffen   Seine Hoheit Scheich ... VAE sowie Herrscher von Dubai , ... der Hilfe (International Humanitarian City IHC) zu verdreifachen, um ...
Breaking Medicine Technology: