Navigation Links
A Better Way to Deliver Cancer Drugs

Researchers are testing a cancer-fighting film that could be applied directly to a tumor site//.

The chitosan-based film, which can be made into any size and shape, is capable of delivering multiple anticancer agents to a tumor site as it dissolves over several weeks. This effectively allows doctors to bypass administering conventional chemotherapy treatment.

A paper-thin, biodegradable implant is proving an effective way to attack cancer cells without punishing the body with chemotherapy. The implant is a clear, flexible film that can be designed in any shape or size. A key ingredient in the film is chitosan, which is derived from a natural material extracted from algae and the exoskeletons of shellfish.

Researchers at the University of Toronto have developed a way to dissolve a high concentration of various cancer-fighting drugs within the film, which is then applied directly to a site where a tumor has been removed. The drugs, which are loaded into polylactide nanoparticles, are control-released over several weeks as the implant breaks down in the body. "The formulation appears to be quite flexible," says Micheline Piquette-Miller, an assistant professor of pharmaceutical sciences at the university and codeveloper of the drug-delivery system. "We can incorporate very diverse types of chemicals into it, and that's what a lot of other systems have had trouble with."

Piquette-Miller and her team are currently focusing their research on ovarian cancer, which has a high relapse rate and typically requires several rounds of chemotherapy following tumor removal.

Cancer drugs administered orally or intravenously often don't reach the right organ or region of the body in strong enough doses. By applying a high concentration of cancer-fighting agents directly to a tumor site, the drugs are more likely to kill the target cells.

"We're also working on an injectable formulation," says Piquette-Miller, ex plaining that an implant could be placed within an area of the body without the need for surgery--ideal for treating prostate, breast, and other forms of cancer. "It's a liquid gel at room temperature, and it forms an implant once it is injected into the body and reaches 37 degrees Celsius," she says.

For the past three years, the team has been testing the system on different strains of mice to determine the efficacy of certain drug concentrations. Two weeks ago the researchers received funding to carry out a series of toxicity studies on mice before beginning human testing. Christine Allen, codeveloper and University of Toronto chemical engineer, says the film has been designed to be flexible enough that it won't puncture internal organs. It's also completely biocompatible. "One of the problems with past systems like this is they're seen as foreign by the body, and tissue grows around it," Allen explains. In this situation, called fibrous encapsulation, the surrounding tissue can often prevent proper drug release or keep the drug from reaching the tumor. "We haven't had this problem," she says.

Source-Bio-Bio Technology
'"/>




Related medicine news :

1. Better prostate cancer detection
2. Better Treatment for obesity
3. For a Better Memory
4. Baby Talk Better Than Adult Speech
5. Drug Combo Works Better for children with ADHD, Tics
6. Better skin with lasers
7. Better diabetes treatment promises Vanadium
8. Better Prostate Cancer Test
9. Better Drug for Heart Transplant
10. Better Diet Even Late in Life May Prolong It
11. Better Care Required for Breast Cancer Survivors
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/26/2016)... ... June 26, 2016 , ... Brent Kasmer, a legally blind and certified personal trainer is helping ... fitness app. The fitness app plans to fix the two major problems leading the fitness ... size fits all type program , They don’t eliminate all the reasons people ...
(Date:6/25/2016)... ... ... temporary closing of Bruton Memorial Library on June 21 due to a possible lice infestation, ... aspect of head lice: the parasite’s ability to live away from a human host, and ... necessary one in the event that lice have simply gotten out of control. , As ...
(Date:6/25/2016)... ... 25, 2016 , ... Dr. Calvin Johnson has dedicated his ... implemented orthobiologic procedures as a method for treating his patients. The procedure is ... to perform the treatment. Orthobiologics are substances that orthopaedic surgeons use to help ...
(Date:6/24/2016)... ... June 24, 2016 , ... Those who have experienced traumatic events may suffer ... unhealthy avenues, such as drug or alcohol abuse, as a coping mechanism. To avoid ... healthy coping following a traumatic event. , Trauma sufferers tend to feel a range ...
(Date:6/24/2016)... MIAMI, Fla. (PRWEB) , ... June 24, 2016 , ... ... Florida Trend magazine’s 2016 Legal Elite. The attorneys chosen by their peers for this ... of Florida. , Seven Greenberg Traurig Shareholders received special honors as members of this ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... DUBLIN , June 24, 2016 ... and Markets has announced the addition of the ... their offering. ... products and provides an updated review, including its applications ... covering the total market, which includes three main industries: ...
(Date:6/24/2016)... 2016 Dehaier Medical Systems Ltd. (NASDAQ: ... markets and sells medical devices and wearable sleep respiratory ... strategic cooperation agreement with Hongyuan Supply Chain Management Co., ... June 20, 2016, to develop Dehaier,s new Internet medical ... Dehaier will leverage Hongyuan Supply Chain,s sales platform to ...
(Date:6/24/2016)... June 24, 2016 According to ... Type (Standard Pen Needles, Safety Pen Needles), Needle Length ... Growth Hormone), Mode of Purchase (Retail, Non-Retail) - Trends ... report studies the market for the forecast period of ... USD 2.81 Billion by 2021 from USD 1.65 Billion ...
Breaking Medicine Technology: