Navigation Links
“Provenge”, Dendritic cell vaccine for Prostate Cancr

An experimental dendritic vaccine has shown significant prognosis and extension of lifetime of men with prostate cancer. The vaccine Provenge is based on dendritic cells, which help the immune system recognize tumors. // “If these results are true, this represents the first proof of principle of a dendritic cell vaccine altering the natural history of a solid tumor”, says Philip Kantoff, Chief of solid tumor oncology at the Dana-Farber Cancer Institute in Boston.

Provenge carries the patients own dendritic cells engineered to express a protein found on about 95% of prostate cancer cells. It is one of more than 15 vaccines in trials for a range of cancers, including lymphoma, melanoma, breast, lung and colorectal cancers, but the first to increase lifespan in advancer cancer patients.

There are also questions about which cells are antigens to use in vaccines and the mode and frequency with which they should be administered. For example, mature dendritic cell vaccines seem to produce the best immune response when given either subcutaneously or intradermally, but not intravenously. Researchers are trying to determine whether vaccines will be need to be designed for specific cancers, or whether a universal vaccine could produce a robust immune response.

The provenge trial has raised several questions of its own: 34% of men given provenge, compared with 11% on placebo, were alive three years on, and lived 4.5 months on average longer. “Because of this, we were all somewhat pleasantly surprised that Provenge showed a survival benefit, says E. Roy Berger, director of the Prostate Cancer Consultation and Treatment service in East Setauket, New York.

“Cancer vaccines prime the immune system to attack cancer, a slower, more indirect process,’ he says. This may mean that survival, and not time to progression is a better measure of efficacy for cancer vaccines, Berger suggests.

Source: Nature Medcine
'"/>




Page: 1

Related medicine news :

1. New hope for cancer victims – will vaccine cure the deadly bug
2. New vaccine helps allergy and asthma patients
3. Man against HIV – new vaccine ready for human trials
4. New vaccine helps allergy and asthma patients
5. Development of AIDS vaccine -- Chiron Corp in talks with four Indian cos
6. HIV did not arise from polio vaccine
7. Double impact vaccine
8. High Demand for a child vaccine
9. A new vaccine for leukemia
10. Shortage of MMR vaccine
11. Anthrax vaccine produced
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/24/2016)... ... ... crisis. Her son James, eight, was out of control. Prone to extreme mood shifts and ... him, he couldn’t control his emotions,” remembers Marcy. “If there was a knife on ... say he was going to kill them. If we were driving on the freeway, ...
(Date:6/24/2016)... ... June 24, 2016 , ... Global law firm Greenberg ... Legal Elite. The attorneys chosen by their peers for this recognition are considered among ... Greenberg Traurig Shareholders received special honors as members of this year’s Legal Elite Hall ...
(Date:6/24/2016)... CA (PRWEB) , ... June 24, 2016 , ... Comfort ... the American Cancer Society and the Road To Recovery® program to drive cancer patients ... seniors and other adults to ensure the highest quality of life and ongoing independence. ...
(Date:6/24/2016)... ... ... People across the U.S. are sharpening their pencils and honing their writing skills ... patients and their families pay tribute to a genetic counselor by nominating him or ... Counselors (NSGC) Annual Education Conference (AEC) this September. , In April, Genome magazine ...
(Date:6/24/2016)... ... June 24, 2016 , ... The Haute ... Dr. Barry M. Weintraub as a prominent plastic surgeon and the network’s newest ... world, and the most handsome men, look naturally attractive. Plastic surgery should be ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... -- , , , WHEN: , ... , , , LOCATION: , , , Online, with free ... EXPERT PANELISTS:  , , , Frost & Sullivan,s Global Vice President ... Industry Analyst, Divyaa Ravishankar and Unmesh Lal, Program Manager , ... is witnessing an exceptional era. Several new demand spaces, such as ...
(Date:6/23/2016)... , June 23, 2016  Guerbet announced today ... Inc.,s Supplier Horizon Award . One ... Guerbet was recognized for its support of Premier members ... through clinical excellence, and commitment to lower costs. ... receive this recognition of our outstanding customer service from ...
(Date:6/23/2016)... , June 23, 2016 The ... it continues to present great opportunities to investors. Stock-Callers.com ... today: Intrexon Corp. (NYSE: XON ), Vertex ... Inc. (NASDAQ: ARNA ), and Regeneron Pharmaceuticals ... these stocks and receive your complimentary trade alerts at: ...
Breaking Medicine Technology: