( Researchers say they've taken a major s...) Pig cloning for organs,,,Health

Researchers say they've taken a major step toward cloning pigs whose hearts, lungs and kidneys could be safely transplanted into humans. Such organs would save the lives of thousands of critically ill people who cannot get transplants because of the shortage of human organs.//

Using the same cloning technique that created the sheep Dolly, scientists say they produced four piglets without one of two genes that lead to the massive rejections that have plagued efforts at xenotransplantation -- the process of replacing human organs with animal organs. "We've knocked out one copy of the gene known to cause this immune response," said Randall Prather at the University of Missouri-Columbia, who performed the nuclear transfer that produced the piglets. "Now we have to do other studies to make the double knockout."

The two genes are actually copies of the same gene, know as GATA1. "This is a major, major step in our attempt to be able to come up with an animal that can be used for transplantation," said Dr. Goran Klintmalm of the Baylor Institute of Transplantation Sciences. "They've knocked out the protein that identifies the organ as being a pig organ rather than a human organ, so it's a very significant advance."

Researchers predict it will be only a matter of months before they genetically engineer piglets without either copy of the GATA1 gene. The next step will be to test the organs by transplanting them into non-human primates. "We think if everything is successful with what we think are the major issues, in two to three years we'll be able to develop a program to test the organs in small numbers of human patients," said Julia Greenstein of Immerge BioTherapeutics, a company created to lead the research project. Initially, researchers think the piglets' hearts, lungs and kidneys could be transplanted into humans.

Currently, about 75,000 Americans are on transplant waiting lists. Most people die waiting for an
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