Navigation Links
$5M Gift Will Attack Lou Gehrig's Disease

Twenty years ago, retail pioneer and philanthropist A. Alfred Taubman lost a good friend to amyotrophic lateral sclerosis a horrifying fatal disease thats better known as Lou Gehrigs disease or ALS.

The memory of watching New York Sen. Jacob Javits slowly succumb to the nerve-killing condition has never left Mr. Taubmans mind. And that memory has motivated him to support ALS research at the University of Michigan Medical School and beyond.

Now, he has greatly increased that support, with a new $5 million gift, and the promise of even further funding when he also donates his share of the royalties from his new book, Threshold Resistance.

The gifts will go to support ALS studies led by U-M neurologist and scientist Eva Feldman, M.D., Ph.D., whose lab has already received two $1 million gifts from Mr. Taubman. She is considered a national leader in ALS treatment and research, and heads the U-M Program for Neurology Research and Discovery.

Together with a team at University of California, San Diego School of Medicine, led by Martin Marsala, M.D., associate professor of anesthesiology, Dr. Feldman and her team will work on several scientific fronts to try to stop or slow the disease. Working at first in animals, then in ALS patients, they hope to make quick progress.

Among the weapons they will deploy against ALS are genetic tools to keep nerve cells from dying, new ways of delivering promising drugs and genes directly into nerve cells, and a potential treatment based on injecting stem cells into the spinal cord. The latter approach, which will require the use of human embryonic stem cells, will be tested at UC San Diego where Dr. Marsala has received additional funding from the California Stem Cell Initiative for his work on spinal cord injury.

"It's hard to imagine a more devastating disease than ALS," says Mr. Taubman, "and we have some of the highest incidence rates in the country r ight here in Michigan. Dr. Feldman and her team are doing miraculous work, and it's important that they have the resources to build on their momentum. I'm not a doctor or a scientist, but I am an optimist who believes in the extraordinary possibilities of modern medicine. This is important work that must continue."

Dr. Feldman calls the gift a major boost to research. Mr. Taubmans generous funding allows us to venture into exciting new territory with stem cells. It gives our patients great hope that our new research with our California colleagues will translate the promise of stem cell technology into the reality of therapy for ALS patients.

Dr. Marsala, who hosted Dr. Feldman recently for several weeks of collaborative research, is an expert on grafting new cells into the spinal cord, and has studied the use of stem cells to treat spinal injuries caused by interruptions in blood flow.

The use of this technique in ALS, which involves the death of the motor neurons that send signals to the muscles and control movement, could be a new frontier in treating the disease.

Already, Marsala and Feldman have performed preliminary research in animals. The promising results from this study, which have not yet been published, form the basis for one prong of the attack on ALS that will be supported by Mr. Taubmans generous gifts.

If additional laboratory work proves successful, a clinical trial in ALS patients could begin within five years.

The other prongs of the attack involve two other laboratory-based approaches that could also lead to clinical trials. The first will develop a method to help ALS-affected nerve cells generate more of the molecules called growth factors that might keep them healthy.

Dr. Feldman and her team have already succeeded in creating a genetic snippet that can encourage cells to increase the number of times their genetic machinery reads the genetic bluepri nt for those growth factors. Preliminary results show that injecting that snippet, called a zinc finger transcription factor, into cells causes more of the growth factor VEGF to be produced and enhances nerve regeneration. Further research on this approach will be made possible by the gift.

The research team also hopes to develop another genetic tool, called a silencing RNA sequence, to keep the cells of ALS patients from making mutant proteins involved in the disease.


'"/>




Related medicine news :

1. One in Three Heart Attack Patients Have No Chest Pains
2. White Cells Count Can Predict Heart Attack Death Risk
3. New drug to treat Heart Attack and damaged tissue
4. Heart Attacks during Menstruation!
5. Increased Heart Attack Risk From Celebrex,Vioxx
6. Supply of Radiopharmaceuticals Hampered by Attacks
7. Attacking therapy with electricity
8. Computer Program can assist to detect Heart Attack
9. Air Pollution and Heart Attacks
10. Recognize Heart Attack Signs
11. Kidney Patients Risk Heart Attacks
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/28/2017)... ... March 28, 2017 , ... Calibration, qualification, and the ... results and maintaining GMP and USP compliance. In a new webinar from METTLER ... requirements " these requirements are explained. The challenge is to determine how ...
(Date:3/28/2017)... (PRWEB) , ... March 28, 2017 , ... With less ... from acne, access to quality care can be limited while the desire to conquer ... offers customized prescription acne care for every customer online, today released its inaugural survey ...
(Date:3/28/2017)... , ... March 28, 2017 , ... Columbus OH. Dr. ... as one of few medical professionals in the country to sit on the 2017 ... Juvly Aesthetics, in just 2 years Dr. Harper helped propel the clinic from a ...
(Date:3/28/2017)... ... March 28, 2017 , ... Public relations pros work ... a variety of business channels. , While many results are clear, much of PR ... program. , When it comes to measurement, firms should always take an all-inclusive ...
(Date:3/28/2017)... ... ... skin is a common and unwelcomed occurrence in people of all ages, genders and ethnicities. ... the discussion of dealing with excess skin oil. “Oily skin is a challenge to many ... help remove the oily shine while keeping the skin fresh and clean,” says Dr. Au. ...
Breaking Medicine News(10 mins):
(Date:3/28/2017)... Elysium Health joins major pharmaceutical companies to ... Cambridge academic scientists through ... Institute today announces Elysium Health as a partner to the ... collaborative projects with academic researchers in Cambridge ... major research investment outside the U.S. for the ...
(Date:3/27/2017)... Summary This report provides all the information ... interests and activities since 2010. Description The Partnering Deals ... the partnering activity of one of the world,s leading life ... upon purchase to ensure inclusion of the most up to ... be delivered in PDF format within 1 working day of ...
(Date:3/27/2017)... , March 27, 2017  ImMAGE Biotherapeutics (OTCMKTS: ... immunotherapy successfully passed early toxicology and efficacy studies. The ... to target a specific protein, MAGE A, in an ... breast cancer. After 4 weeks of ... to show very little toxicity in a full toxicology ...
Breaking Medicine Technology: