( ght suggest that the two neurotransmitt...)$1.5 Million Grant to Yale for Narcolepsy-Neurotransmitter Study,Health

ght suggest that the two neurotransmitters would simply cancel the actions of each other,” van den Pol said. “But, interestingly, in the continuing presence of both neurotransmitters, the inhibitory MCH cell response to dynorphin rapidly declined, whereas the excitatory response to hypocretin persisted.” Therefore, he said, low levels of release of both transmitters might favor inhibition, whereas high levels of release might swing the tide over to excitation and increase cognitive arousal.

However, on another target, NPY neurons, hypocretin directly excited the cells, byt dynorphin had little direct effect. Rather, dynorphin contributed to increased nerve cell activity by reducing the release of inhibitory neurotransmitters onto the NPY cells. In this case, the transmitters act synergistically to excite the NPY cell.

Under the NIH grant, van den Pol and colleagues will study the effects of both naturally occurring neuroactive compounds, as well as man made drugs, to determine how they influence the hypocretin cells, and, ultimately, cognitive arousal.

Source-YALE UniversitySRM
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