Navigation Links
"Trojan Horse" Agent Halts Bone Metastasis in Mice

ntenance or promoted growth of blood vessels to feed the neophyte cancer, Rosenblum said

To find out, Rosenblum designed an experiment with VEGF121/rGel, an agent he and his colleagues began to develop several years ago. They created the drug by fusing the smallest of VEGF proteins (VEGF 121) to a genetically engineered toxin, gelonin, derived from a plant that grows wild in India, and used bacteria to produce the fusion protein. The agent is designed to enter new blood vessel cells in tumors through expressed VEGF receptors and, once inside, the "Trojan Horse" toxin destroys the cell, disrupting the ability of tumors to form blood vessels to supply the nutrients they need to grow. Animal studies previously conducted by the researchers have shown that the protein can selectively destroy blood vessels feeding human solid tumors.

In this study, investigators implanted human prostate cancer cells, which are highly metastatic to bone, directly into the leg bone marrow of experimental mice in order to simulate a bone metastasis. A week later, they treated the animals with five staggered doses of VEGF121/rGel delivered through intravenous injections.

Half of the treated mice did not develop any bone tumors, Rosenblum says. "There was no evidence of cancer growth," he says, adding, "We don't know why the treatment didn't work in the other half of the mice, but we may have started therapy too late."

Rosenblum and his research team then found that VEGF121/rGel dramatically reduced the number of osteoclast cells in the leg bones and further research demonstrated that pre-osteoclast like cells, known as monocytes, had been expressing a receptor, Flt-1, designed to latch on to the VEGF protein secreted by cancer cells.

When activated by maturation factors including VEGF, the pre-osteoclasts differentiated into mature osteoclasts and chew up bone tissue, providing the tumor new space to grow. The mature osteoclast cells
'"/>




Page: 1 2 3

Related medicine news :

1. Effective And Economical Agent For Anthrax
2. Gold Nanoparticles: Agents For Noninvasive Cancer Therapy
3. Revelation Of Cancer Agent Could Help In Developing Effective Cancer Drugs
4. Sunitinib a Promising Agent for Treatment of Renal Cell Cancer
5. New Multi-Modal Contrast Agents, A Boon For Medical Imaging
6. Bird Flu May Evolve Into More Transmissible Agent In Humans
7. Prion Disease Agent Causes Heart Damage
8. Alzheimers Drug can be Used to Treat Nerve Agent and Pesticide Poisoning
9. An Infectious Agent of Deception, Exposed Through Proteomics
10. MRI Contrast Agent Linked to Complication in Renal Patients
11. Researchers Develop Resin Beads That Capture Mad Cow Disease Agent From Blood
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Trojan Horse Agent Halts Bone Metastasis Mice

(Date:12/25/2014)... (PRWEB) December 26, 2014 Recently, Dylan ... dresses, has excitedly released its collection of discounted prom ... to Percy, a senior spokesman of the company, the ... of this promotion is to expand the UK market. ... in several different colors, lengths, and styles: A-line strapless, ...
(Date:12/25/2014)... December 25, 2014 BambooFlooringChina.com sells many ... quality bamboo flooring. Today, the company announces big ... many styles and colors. , BambooFlooringChina.com is the world’s ... the promotion is valid until Jan. 20, 2015. , ... and woven with a natural thread. All the bamboo ...
(Date:12/25/2014)... Recently, LunaDress.co.uk has updated its blog to provide ... Now, all of the models at LunaDress.co.uk come with big discounts, ... the wedding veil can turn out to be a most exciting ... veil can always bring surprise to a wedding. On the updated ... choose veils for a big day . , Going out ...
(Date:12/25/2014)... common during the holidays, but there are strategies that can ... arrive at a party hungry. It may seem logical to ... party, but deprivation leads to hunger, and hunger leads to ... Mount Kisco, N.Y., said in a hospital news release. ... to have a snack before attending a party when you ...
(Date:12/25/2014)... 25, 2014 AngelWeddingDress.com tries its best ... online realm. Today, the business has introduced its new ... prom dress promotion. , The new prom outfits are ... every dress lover. They are specially designed for 2015. ... dresses should visit its website before Jan. 26, ...
Breaking Medicine News(10 mins):Health News:Dylan Queen: Cheap Prom Dresses for the UK Market 2Health News:Various Styles of Bamboo Mats in Many Colors from BambooFlooringChina.com 2Health News:LunaDress Provides Professional Tips On Shopping Wedding And Prom Dresses 2Health News:Angelweddingdress 2015 Prom Dresses Online Now 2
... --, -- Management expects to report revenues of approximately, ... the Fiscal Year which ends June 30, 2009. ... approximately $12.4 million and, $1.8 million, respectively., ... $10.5 million in net income, representing approximately 40%, ...
... Hospital Home Health and Hospice Services, the oldest homecare ... entered into a business relationship with Cardiocom (R) ... chronic illness. Cardiocom, the Experts in Telehealth(SM), is ... of award-winning telehealth solutions. , , Cardiocom,s telehealth ...
... , DOYLESTOWN, Pa., June 18 The Quigley Corporation, ... announced that Ted Karkus, Chairman of the Board of The Quigley ... of Directors of the Company. Mr. Karkus will serve in this ... rate of $5,000 per week for his services. , , ...
... NEW YORK , June 18 HLTH Corporation (Nasdaq: ... (Nasdaq: WBMD ), announced today that they have entered ... into WebMD in a tax-free, all-stock transaction. WebMD will be ... serve as Chairman of the Board and Wayne Gattinella will serve ...
... June 18 Multitask Productions LLC is changing the way you ... community featuring dynamic videos of exercises and a content-rich blog designed ... daily routine. , , , From doing ... toned thighs, SqueezeItIn.com shows you how to make fitness fit into ...
... Group, Inc. (Nasdaq: ENSG ), the parent company ... and assisted living companies, announced today that its Board of ... share of Ensign common stock, payable on or before July ... 2009. Ensign has been a dividend-paying company since 2002. ...
Cached Medicine News:Health News:Tianyin Pharmaceutical Co., Inc. Provides Fiscal 2010 Guidance 2Health News:Tianyin Pharmaceutical Co., Inc. Provides Fiscal 2010 Guidance 3Health News:Tianyin Pharmaceutical Co., Inc. Provides Fiscal 2010 Guidance 4Health News:Tianyin Pharmaceutical Co., Inc. Provides Fiscal 2010 Guidance 5Health News:Englewood Hospital Home Health and Hospice Services Selects Cardiocom Telehealth Technology 2Health News:Ted Karkus Appointed Interim Chief Executive Officer Of The Quigley Corporation 2Health News:HLTH Corporation and WebMD Health Corp. Announce Agreement to Merge 2Health News:HLTH Corporation and WebMD Health Corp. Announce Agreement to Merge 3Health News:HLTH Corporation and WebMD Health Corp. Announce Agreement to Merge 4Health News:HLTH Corporation and WebMD Health Corp. Announce Agreement to Merge 5Health News:New Fitness Website Offers a No Gym, No Equipment, No Excuses Workout Solution: SqueezeItIn.com Challenges You to Let Life Be Your Workout 2
(Date:12/24/2014)... , Dec. 24, 2014 Soligenix, ... late-stage biopharmaceutical company developing products that address unmet ... and biodefense, announced today that on December 24, ... offering. The Company raised approximately $2.3 ... intends to use the net proceeds from the ...
(Date:12/24/2014)... FLINT, Mich. , Dec. 24, 2014  Diplomat ... largest independent specialty pharmacy, is proud to announce ... and quality at Diplomat, will take office as the ... 2015. The formal induction ceremony will take place Feb. ... which will be held at the Renaissance Center in ...
(Date:12/24/2014)... , Dec. 23, 2014 PuraMed BioScience®, ... of over-the-counter (OTC) medicinal and healthcare products, announced it ... MigraPure® H, a hemp-based, advanced headache relief product, for ... in Colorado , Washington ... With the MigraPure H Advanced headache relief ...
Breaking Medicine Technology:Soligenix Announces Closing of Public Offering of Units 2Soligenix Announces Closing of Public Offering of Units 3Diplomat's senior director of education and quality to be inducted as 2015 president of the Michigan Pharmacists Association 2Diplomat's senior director of education and quality to be inducted as 2015 president of the Michigan Pharmacists Association 3PuraMed BioScience Nears Final Stages Needed for Distribution of MigraPure H 2PuraMed BioScience Nears Final Stages Needed for Distribution of MigraPure H 3
... & Melinda Gates Foundation today announced that Dr. Trevor Mundel ... Mundel, who is currently global head of development for Novartis ... work at the foundation on December 1. "We ... our global health program," said Bill Gates, co-chair of the ...
... Inc. is pleased to announce its exclusive agreement with ... automated FIT product, a fecal occult blood analyzer that ... the early detection of colorectal cancer. The agreement includes ... and OC-Sensor Diana, a high throughput automated FIT analyzer, ...
Cached Medicine Technology:Gates Foundation Names Dr. Trevor Mundel to Lead Global Health Program 2Polymedco, Inc., and Cardinal Health Sign Agreement for Distribution of Oncologic Diagnostic Test Kits to Acute Care Market 2
Inquire...
...
... is your system. CONMED's family of products ... New, state-of-the art generators feature proprietary Energy ... continuous synchronization of current and voltage in ... enables the system to sample current and ...
... PoliPhase® is a biologically based adhesive ... component system consisting of a liquid ... control of internal bleeding. ... flow on to a prepared wound ...
Medicine Products: