Navigation Links
"Trojan Horse" Agent Halts Bone Metastasis in Mice

ntenance or promoted growth of blood vessels to feed the neophyte cancer, Rosenblum said

To find out, Rosenblum designed an experiment with VEGF121/rGel, an agent he and his colleagues began to develop several years ago. They created the drug by fusing the smallest of VEGF proteins (VEGF 121) to a genetically engineered toxin, gelonin, derived from a plant that grows wild in India, and used bacteria to produce the fusion protein. The agent is designed to enter new blood vessel cells in tumors through expressed VEGF receptors and, once inside, the "Trojan Horse" toxin destroys the cell, disrupting the ability of tumors to form blood vessels to supply the nutrients they need to grow. Animal studies previously conducted by the researchers have shown that the protein can selectively destroy blood vessels feeding human solid tumors.

In this study, investigators implanted human prostate cancer cells, which are highly metastatic to bone, directly into the leg bone marrow of experimental mice in order to simulate a bone metastasis. A week later, they treated the animals with five staggered doses of VEGF121/rGel delivered through intravenous injections.

Half of the treated mice did not develop any bone tumors, Rosenblum says. "There was no evidence of cancer growth," he says, adding, "We don't know why the treatment didn't work in the other half of the mice, but we may have started therapy too late."

Rosenblum and his research team then found that VEGF121/rGel dramatically reduced the number of osteoclast cells in the leg bones and further research demonstrated that pre-osteoclast like cells, known as monocytes, had been expressing a receptor, Flt-1, designed to latch on to the VEGF protein secreted by cancer cells.

When activated by maturation factors including VEGF, the pre-osteoclasts differentiated into mature osteoclasts and chew up bone tissue, providing the tumor new space to grow. The mature osteoclast cells
'"/>




Page: 1 2 3

Related medicine news :

1. Effective And Economical Agent For Anthrax
2. Gold Nanoparticles: Agents For Noninvasive Cancer Therapy
3. Revelation Of Cancer Agent Could Help In Developing Effective Cancer Drugs
4. Sunitinib a Promising Agent for Treatment of Renal Cell Cancer
5. New Multi-Modal Contrast Agents, A Boon For Medical Imaging
6. Bird Flu May Evolve Into More Transmissible Agent In Humans
7. Prion Disease Agent Causes Heart Damage
8. Alzheimers Drug can be Used to Treat Nerve Agent and Pesticide Poisoning
9. An Infectious Agent of Deception, Exposed Through Proteomics
10. MRI Contrast Agent Linked to Complication in Renal Patients
11. Researchers Develop Resin Beads That Capture Mad Cow Disease Agent From Blood
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Trojan Horse Agent Halts Bone Metastasis Mice

(Date:9/2/2014)... be a new salve to dominate medicine cabinets of the ... Salamanders may not be the cuddliest of animals, but they ... damaged body parts. Now, a new report published in the ... , identifies a small protein (called a "peptide") from the ... the secret of this amazing wound healing trick in humans. ...
(Date:9/2/2014)... made it clear that a mother,s eating habits prior ... profound impact on her offspring and their propensity for ... the mechanisms behind this phenomenon were unclear. According to ... The FASEB Journal F , scientists using ... mother,s diet and an offspring,s risk of future obesity. ...
(Date:9/2/2014)... 2014 Concorde Career College North ... receive the 2014 Excellence in Community Service Award ... Colleges (ACCSC). , Every year, the Accrediting Commission ... who make outstanding contributions in their local community ... the scope and impact of the community service ...
(Date:9/2/2014)... that the key to more youthful immune function might ... published in the Journal of Leukocyte Biology ... of old mice had different responses to Mycobacterium ... changes were reversed by ibuprofen. , "Inflammation in old ... Joanne Turner, Ph.D., a researcher involved in the work ...
(Date:9/2/2014)... Splashtop Inc. , the worldwide ... NTT DoCoMo to deliver Splashtop Business Lite ... Lite is included in NTT DoCoMo’s “Business Plus” program. ... that empower users to remote access their corporate computers ... 18 million users worldwide. Splashtop delivers the best ...
Breaking Medicine News(10 mins):Health News:Salamander skin peptide promotes quick and effective wound healing in mice 2Health News:How genes link a mother's diet to the risk of obesity in her offspring 2Health News:Concorde Career College North Hollywood Awarded 2014 Excellence in Community Service Award 2Health News:Splashtop and NTT DoCoMo Partner to Deliver “Splashtop Business Lite” Secure Remote Access Solution to Business Customers 2
... Barbara Davis Center for Childhood Diabetes at the University ... against type 1 diabetes: The Juvenile Diabetes Research Foundation ... JDRF Autoimmunity Center at the Barbara Davis Center for ... Autoimmunity Center will receive approximately $1 million a year ...
... are lucky in love. , At least thats how ... research on the mating habits and nervous systems of ... both the voles behavior and their brains, appears in ... Academy of Sciences. , Prairie voles, aka Microtus ochrogaster, ...
... 28 The Department of,Veterans Affairs (VA) today ... Marion, Ill., hospital. The VA today released the ... at the Marion,facility., VA,s Inspector General was ... for Health, on September 10, 2007 and also ...
... Reasons for the association are unknown, researchers say , , ... Korean study found frequent snoring was associated with the ... they aren,t sure why. , "The mechanisms underlying the ... said the report, published in the Jan. 28 issue ...
... to Launch Vitals.com Which Offers Free Comprehensive Doctor ... Information and ... ), one of the,nation,s top 10 public relations firms, today announced ... and execute a,comprehensive communications program for the free, online doctor evaluation,service., ...
... the use of financial,incentives for health care ... non-profit National Business,Coalition on Health (NBCH) recently ... discuss an emerging trend in employer-sponsored health,care: ... choice of,healthier lifestyles and high value medical ...
Cached Medicine News:Health News:JDRF to establish an autoimmunity center at University of Colorado Denver 2Health News:Zoologists: Lusty voles, mindless of danger, mate like rabbits 2Health News:Zoologists: Lusty voles, mindless of danger, mate like rabbits 3Health News:VA Leadership Vows to Fix Problems Identified at Marion VA Medical Center 2Health News:VA Leadership Vows to Fix Problems Identified at Marion VA Medical Center 3Health News:VA Leadership Vows to Fix Problems Identified at Marion VA Medical Center 4Health News:Study Links Snoring to Chronic Bronchitis 2Health News:MWW Group Selected by First-Ever Online Doctor Evaluation Service Vitals.com 2Health News:National Business Coalition on Health Convenes Multi-Stakeholder Leadership Group to Address Value Based Purchasing Trends 2
(Date:9/2/2014)... 2, 2014 , Registry provides ... of life and treatment satisfaction [ 1 ...        (Photo: ... September 2014, Barcelona, Spain : Daiichi ... oF thromboembolic events-European Registry in Atrial Fibrillation (PREFER in ...
(Date:9/2/2014)... 2014  Edison Nation Medical, the premier healthcare ... American Association for Respiratory Care ( AARC ), ... Edison Nation Medical, which brings 12+ years experience ... their innovation ideas, will work with AARC to ... 50,000 respiratory therapists in bringing their product innovation ...
(Date:9/2/2014)... 2, 2014  EMD Serono, Inc., a subsidiary of ... today that Drew Young has joined the ... this capacity, he will be responsible for leading the ... including future products.   Bringing more than 20 ... sales efforts at pharmaceutical and biotech companies, Mr. Young ...
Breaking Medicine Technology:One Year Data from the PREFER in AF Registry Show Significant Changes in Atrial Fibrillation (AF) Management in Europe and Implementation of Clinical Guidelines 2One Year Data from the PREFER in AF Registry Show Significant Changes in Atrial Fibrillation (AF) Management in Europe and Implementation of Clinical Guidelines 3One Year Data from the PREFER in AF Registry Show Significant Changes in Atrial Fibrillation (AF) Management in Europe and Implementation of Clinical Guidelines 4One Year Data from the PREFER in AF Registry Show Significant Changes in Atrial Fibrillation (AF) Management in Europe and Implementation of Clinical Guidelines 5One Year Data from the PREFER in AF Registry Show Significant Changes in Atrial Fibrillation (AF) Management in Europe and Implementation of Clinical Guidelines 6One Year Data from the PREFER in AF Registry Show Significant Changes in Atrial Fibrillation (AF) Management in Europe and Implementation of Clinical Guidelines 7One Year Data from the PREFER in AF Registry Show Significant Changes in Atrial Fibrillation (AF) Management in Europe and Implementation of Clinical Guidelines 8Edison Nation Medical and AARC Team Up To Promote Innovation in Respiratory Care 2Edison Nation Medical and AARC Team Up To Promote Innovation in Respiratory Care 3EMD Serono Appoints Drew Young to Senior Vice President, Neurology and Immunology 2EMD Serono Appoints Drew Young to Senior Vice President, Neurology and Immunology 3EMD Serono Appoints Drew Young to Senior Vice President, Neurology and Immunology 4
... focus, and new drug-eluting technologies to drive lower extremity ... Millennium Research Group WALTHAM, Mass., May 28 ... for Peripheral Vascular (PV) Devices 2009 report, rapid ... lower extremity peripheral artery disease in Europe is being ...
... MATEO¿ Calif.¿ May 28 Results and additional analyses ... clinical trial of Corthera,s investigational drug relaxin for the ... the Heart Failure Congress, the annual meeting of the ... in Nice, France. Marco Metra, M.D., professor of ...
Cached Medicine Technology:Lower Extremity Peripheral Vascular Stent and Balloon Catheter Markets to Exceed $180 Million in Europe by 2013 2Lower Extremity Peripheral Vascular Stent and Balloon Catheter Markets to Exceed $180 Million in Europe by 2013 3Results and Additional Analyses From Efficacy and Safety Study of Corthera's Relaxin in Acute Heart Failure to be Presented at Heart Failure Congress 2009 2
... Cronin, Inc. is a ... Footwear, Orthopedic Softgoods, and ... Our products are of ... available in the USA ...
... 3-Point® Polycentric Hinged Ulnar Deviation Splint ... align the hand with ulnar deviation at ... impede grasp or pinch. Radial and ulnar ... ensure unimpeded flexion and extension. Padded, malleable ...
... immobilizes and positions the elbow at 122 ... prominent. Restricts full extension and flexion to ... helps prevent pain and irritation due to ... post-cast removal. Rigid, high-density beige polyethylene shell ...
... Orthosis For quick, efficient immobilization of ... immobilizes and protects the fracture and ... comfort, support, and conformity to the ... shell may be gently heated (with ...
Medicine Products: