Navigation Links
"Trojan Horse" Agent Halts Bone Metastasis in Mice

A novel vascular targeting agent completely prevented the development of bone tumors in 50 percent of the mice tested in a preclinical //study, providing early evidence that it could treat, or thwart, growth of tumors in bone, a common destination for a number of cancers when they start to spread.

Researchers at The University of Texas M. D. Anderson Cancer Center reported in the journal Cancer Research that this "Trojan Horse" agent, VEGF121/rGel, stopped specialized cells within the bone from chewing up other bone material to make room for the implanted tumor to grow.

Although this study tested the ability of VEGF121/rGel to halt the growth of human prostate cancer cells in the bones of mice, investigators say it likely could help prevent the growth of other cancers in bones such as breast, multiple myeloma, lung and renal cell.

"Many tumors invade bone in the same way, so these findings suggest it may be possible to shut down this process regardless of the tumor type," says the study's lead author, Michael G. Rosenblum, Ph.D., professor in the Department of Experimental Therapeutics. "If that could be done - and we are a long way from determining if it is possible - we may be able to offer the first treatment that specifically targets bone metastasis."

The study also revealed critical information about the role of vascular endothelial growth factor (VEGF) in the development of tumors in bone, says Rosenblum. VEGF is a signaling protein involved in the creation of new blood vessels, but in this study the researchers found that it plays a surprising role in the remodeling of bone tissue.

In the normal maintenance of bones, a balance exists between activity of cells known as osteoclasts, which break down and resorb bone matrix, and osteoblasts, which form new bone. Researchers know that tumor cells that metastasize to bones release VEGF, but what they did not know is whether the protein interrupted bone mai
'"/>




Page: 1 2 3

Related medicine news :

1. Effective And Economical Agent For Anthrax
2. Gold Nanoparticles: Agents For Noninvasive Cancer Therapy
3. Revelation Of Cancer Agent Could Help In Developing Effective Cancer Drugs
4. Sunitinib a Promising Agent for Treatment of Renal Cell Cancer
5. New Multi-Modal Contrast Agents, A Boon For Medical Imaging
6. Bird Flu May Evolve Into More Transmissible Agent In Humans
7. Prion Disease Agent Causes Heart Damage
8. Alzheimers Drug can be Used to Treat Nerve Agent and Pesticide Poisoning
9. An Infectious Agent of Deception, Exposed Through Proteomics
10. MRI Contrast Agent Linked to Complication in Renal Patients
11. Researchers Develop Resin Beads That Capture Mad Cow Disease Agent From Blood
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Trojan Horse Agent Halts Bone Metastasis Mice

(Date:5/25/2015)... May 25, 2015 According to a ... market growth in hip external fixation market is driven ... U.S. population and advancements in infection prevention technologies. As ... fractures are currently accounting for the largest total number ... with falls and accidents. As a result, the average ...
(Date:5/25/2015)... May 25, 2015 Join Fiona's Soccer Camp ... two-hour instructional clinic. Irish National Player, Fiona O'Sullivan will ... them a taste of her coaching style. Fiona has three ... Camps in Novato are at Lynwood Elmentary School (June 15-19) ... High School - June 6th, 2015 - 1:00-3:00pm. Bring a ...
(Date:5/24/2015)... Pacific Prime has announced that they have launched the ... cost of individual international health insurance. Titled: The Cost of Health ... of health insurance in six top expat destinations, which are also ... Hong Kong , Singapore , China , ... the UK , Article 2 presents an in-depth look ...
(Date:5/24/2015)... May 24, 2015 Scientists with Cardno ... on air quality compliance issues that may have raised ... Surviving Mesothelioma has just posted an article on the ... , The group found airborne asbestos levels well above ... between 1984 and 2011. , “Asbestos compliance sampling data ...
(Date:5/24/2015)... 2015 Medicx Media Solutions ... executive Jay Krihak as its head of programmatic ... up its expertise and leadership position in the ... Health sectors. , Krihak is an experienced, award-winning ... Krihak led sales planning teams for mobile platform ...
Breaking Medicine News(10 mins):Health News:DePuy Synthes and Stryker Lead Orthopedic External Fixation Trauma Device Market Due to Increased Hip Fractures in the U.S. 2Health News:DePuy Synthes and Stryker Lead Orthopedic External Fixation Trauma Device Market Due to Increased Hip Fractures in the U.S. 3Health News:US Sports Camps and Nike Soccer Camps Offer Complimentary Instructional Clinic with Fiona's Soccer Camp 2Health News:Pacific Prime Releases 2nd Article of Cost of Health Insurance Report 2Health News:New Analysis Finds Too Many Employers Ignored OSHA Asbestos Guidelines, According to Surviving Mesothelioma 2Health News:Medicx Media Solutions Expands Executive Team 2
... News) -- Intensive control of blood sugar levels reduces ... diabetics, new research indicates. However, the evidence did ... actually developing severe kidney disease. The two signs ... conditions known as microalbuminuria and macroalbuminuria. These are characterized ...
... (May 29, 2012) Researchers from South Korea, Sweden, ... to restore neuron function to parts of the brain ... pluripotent stem cells into animal models. Induced ... human somatic cells such as skin, and can be ...
... May 29, 2012 Older adults who don,t get ... exposure may be at increased risk of developing mobility ... Baptist Medical Center. , "This is one of the first ... the onset of new mobility limitations or disability in older ...
... genetic disorders have uncovered insights into those diseases ... divide. Focusing on the cohesin complex, a group ... pairs, scientists have discovered mutations that disrupt cohesin, ... cohesinopathies. "We are learning more about how ...
... May 29, 2012 -- The discovery of a mummified ... scientific team to conduct a genetic analysis on a liver ... C2 sequence common in Southeast Asia. Additional analysis ... model to study the evolution of chronic hepatitis B and ...
... Texas For 50 years scientists have been unsure how the ... basic innate immune responses. That mystery has now been solved, thanks ... The answers may help clear the way for a ... such as V. cholerae , but instead disable their defenses ...
Cached Medicine News:Health News:Tight Blood-Sugar Control Shows Mixed Results for Health of Kidneys: Study 2Health News:Researchers restore neuron function to brains damaged by Huntington's disease 2Health News:Older adults may need more vitamin D to prevent mobility difficulties 2Health News:Mutations impair childhood growth and development by disrupting organization of chromosome pairs 2Health News:16th-century Korean mummy provides clue to hepatitis B virus genetic code 2Health News:50-year cholera mystery solved 2
(Date:5/22/2015)... May 22, 2015 Electrophysiologist Kevin Makati, ... traveled to Boston, MA ... 2015 Heart Rhythm Society conference. These scientific sessions ... on the ideas, people and technology that propel ... a hybrid, minimally invasive cardiac operation that combines ...
(Date:5/22/2015)... and KING OF PRUSSIA, Pa. , May ... has awarded CSL Behring its 2015 Corporate Leadership ... to advancing science and improving the care of the bleeding ... , CEO and Managing Director, CSL Limited, during the NHF ... on May 21. "The National Hemophilia Foundation ...
(Date:5/22/2015)... , May 22, 2015   InspireMD, Inc. ... stent embolic protection systems ("EPS"), today announced that its CGuard ... lead by principle investigator Prof. Piotr Musialek , at ... Paris, France . PARADIGM, an ... R cutaneous c A roti D revascularization I ...
Breaking Medicine Technology:St. Joseph's Hospital Heart Institute Physician Presents at Heart Rhythm Society 2St. Joseph's Hospital Heart Institute Physician Presents at Heart Rhythm Society 3National Hemophilia Foundation Honors CSL Behring with Corporate Leadership Award 2National Hemophilia Foundation Honors CSL Behring with Corporate Leadership Award 3National Hemophilia Foundation Honors CSL Behring with Corporate Leadership Award 4InspireMD's CGuardTM Highlighted at Clinical Presentation at EuroPCR 2015 Conference 2InspireMD's CGuardTM Highlighted at Clinical Presentation at EuroPCR 2015 Conference 3InspireMD's CGuardTM Highlighted at Clinical Presentation at EuroPCR 2015 Conference 4
... Pharmaceutical Companies, Inc. (NYSE: PRX ) announced today ... on Thursday, May 5, 2011 at 9:00 AM ET to ... its financial results on May 5, 2011 before the market ... made via the Company,s website at www.parpharm.com .Dial-in InformationDomestic: ...
... that a new market research report is available in ... 2011-2021 http://www.reportlinker.com/p0470100/World-Influenza-Vaccines-Market-2011-2021.html ... answers to benefit your work? Our new report shows ... influenza vaccines from 2009 to 2021.  There, ...
Cached Medicine Technology:Reportlinker Adds World Influenza Vaccines Market 2011-2021 2Reportlinker Adds World Influenza Vaccines Market 2011-2021 3Reportlinker Adds World Influenza Vaccines Market 2011-2021 4Reportlinker Adds World Influenza Vaccines Market 2011-2021 5Reportlinker Adds World Influenza Vaccines Market 2011-2021 6Reportlinker Adds World Influenza Vaccines Market 2011-2021 7Reportlinker Adds World Influenza Vaccines Market 2011-2021 8Reportlinker Adds World Influenza Vaccines Market 2011-2021 9Reportlinker Adds World Influenza Vaccines Market 2011-2021 10Reportlinker Adds World Influenza Vaccines Market 2011-2021 11Reportlinker Adds World Influenza Vaccines Market 2011-2021 12Reportlinker Adds World Influenza Vaccines Market 2011-2021 13Reportlinker Adds World Influenza Vaccines Market 2011-2021 14Reportlinker Adds World Influenza Vaccines Market 2011-2021 15Reportlinker Adds World Influenza Vaccines Market 2011-2021 16Reportlinker Adds World Influenza Vaccines Market 2011-2021 17Reportlinker Adds World Influenza Vaccines Market 2011-2021 18
... dilution nebulizer allows the clinician to deliver up ... into the side port for precise high flow ... for normal flow patients, delivers 8-12 lpm in ... side port. For your high flow needs, DHD ...
Rotary Piston Mini Nebulizer...
... Solight® Forceps Lighting System is a ... where it's needed most---in small and deep ... fiber-optic cable and stainless steel light rod ... forceps while minimizing heat conduction. The system ...
... HELION family consists of four models in ... - to ensure you find the right ... singly or in a combination of two ... the standard design with an on/off switch ...
Medicine Products: