llaborators providing patient samples, set out to determine if a protein profile in the peripheral blood could predict clinical benefit measured in terms of patient survival to EGF receptor TKIs.

Using mass spectrometry, the researchers analyzed pre-treatment blood samples from 139 patients who had been treated with gefitinib (three patient cohorts in Italy and Japan), identified a pattern of eight proteins that was correlated with survival, and developed a prediction algorithm. They then tested the algorithm in two additional groups of patients 67 gefitinib-treated patients in Italy and 96 erlotinib-treated patients in a U.S. Eastern Cooperative Oncology Group protocol. At the time of the mass spectrometry analysis and classification, the researchers were blind to the survival status of the patients.

We classified the patients as being either likely to benefit (good) or not likely to benefit (poor) from the TKIs, Carbone said. The method was highly successful in predicting a survival benefit. In the gefitinib-treated group, patients classified as good had a median survival of 207 days whereas those classified as poor had a median survival of 92 days. In the erlotinib-treated group, median survivals for good and poor groups were 306 and 107 days, respectively.

The fact that the signature, which was developed from gefitinib-treated patients, also accurately predicted a survival benefit for erlotinib-treated patients buoys Carbones confidence in the algorithm, he said, since these two drugs share a common mechanism of action. The method was not prognostic it did not predict a survival benefit in three different control groups of patients treated with either chemotherapy or surgery alone.

The investigators are currently working with the Eastern Cooperative Oncology Group to develop a prospective national phase III trial that will test the prediction methods clinical benefit in lung cancer patients who are just
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