Navigation Links
"Miracle" Cancer Drug Gleevec Can be Toxic to the Heart

Gleevec, the wildly successful poster-child of a new generation of cancer drugs aimed at specific targets in the cancer cell, can be dangerous to the heart.// Not only that, but other similarly based drugs – called tyrosine kinase inhibitors – could lead to heart problems as well, say researchers at the Center for Translational Medicine at Jefferson Medical College in Philadelphia.

A team of scientists led by Thomas Force, M.D., James C. Wilson Professor of Medicine at Jefferson Medical College of Thomas Jefferson University, has shown in studies in both mice and in heart cells in culture that Gleevec can cause heart failure. The results of the study, prompted by 10 patients with chronic myelogenous leukemia (CML) who developed severe congestive heart failure while taking Gleevec, appear July 23, 2006, in an advanced online edition of the journal Nature Medicine.

“We found that the molecular target of the drug, the Abelson tyrosine kinase (ABL) protein, serves a maintenance function in cardiac muscle cells and is necessary for their health,” Dr. Force explains. “While the cancer is treated effectively, there will be some percentage of patients who could experience significant left ventricular dysfunction and even heart failure from this.”

“Gleevec is a wonderful drug and patients with these diseases need to be on it,” he says. “We’re trying to call attention to the fact that Gleevec and other similar drugs coming along could have significant side effects on the heart and clinicians need to be aware of this. It’s a potential problem because the number of targeted agents is growing rapidly.”

Gleevec is a new type of cancer drug – the first of its kind developed to fight cancer by turning off an enzyme that causes cells to become cancerous and multiply. In CML, an enzyme called ABL goes in overdrive because of a chromosomal mix-up that occurs during blood cell development. The genes ABL and BCR become fused and produce a
'"/>




Page: 1 2 3

Related medicine news :

1. Fibroids unlikely to Turn Cancerous
2. Virus Level could Predict Cervical Cancer Risk
3. Cancer Doctors Okays Controversial Prostate Therapy
4. Potential New Cancer Gene Identified
5. Consensus on "Combination Therapy" for Breast Cancer
6. Cancers of Colon & Rectum linked to Cigarette Smoking
7. Life Saving Cancer Drugs – From Chicken! Possible Says Dolly’ Creatos
8. The Cancer Rumour mill working over time
9. Cancer drugs in development nearly doubled since 1995
10. Radioactive Seeds used in Prostate Cancer treatment can migrate with the body
11. Cancer patients turning to Internet for information
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Miracle Cancer Drug Gleevec Can Toxic the Heart

(Date:8/28/2014)... MarijuanaDoctors.com is enthralled to announce the addition ... Livermore, California. As always, MarijuanaDoctors.com prides itself on affiliating ... in accordance with that, we are excited to introduce ... , Initially finding his calling for healing and interest ... shaped by his mother’s severe arthritis to finally become ...
(Date:8/28/2014)... Texas (PRWEB) August 28, 2014 The need ... growth over the past few years. The new location - ... offer higher quality and larger office space than TLC had ... , “We are pleased about our new location because ... “While our suite will be double in size compared to ...
(Date:8/27/2014)... Villanova, PA (PRWEB) August 28, 2014 ... (published by iUniverse) takes readers on the thrilling adventures ... The book, published in 2012, is gearing up for ... 2014. , Split into two novellas , “Prescription: ... orthopedic surgeon who finds himself dodging assassination attempts and ...
(Date:8/27/2014)... Recently, BambooIndustry.com, an innovative company that provides many kinds of ... panels are now offered on its website. In addition, ... All people that place an order for its newly released ... percent off. , The company’s senior spokesman was excited ... our new and old customers can buy cheap bamboo panels ...
(Date:8/27/2014)... National Resident Matching Program International ... Medical Education in Europe (AMEE) Conference being held at ... – September 3, 2014. As an exhibitor, NRMPI ... community, share the benefits of its matching services, and ... in countries throughout the world. , “Exhibiting ...
Breaking Medicine News(10 mins):Health News:Army Colonel Dr. James Patel Joins the Medical Marijuana Industry 2Health News:Army Colonel Dr. James Patel Joins the Medical Marijuana Industry 3Health News:Army Colonel Dr. James Patel Joins the Medical Marijuana Industry 4Health News:William H. Simon Launches New Marketing Campaign for Book 2Health News:BambooIndustry.com: Cheap Bamboo Panels for Clients Worldwide Offered Online 2Health News:National Resident Matching Program International (NRMPI) to Exhibit at the 2014 AMEE Conference 2
... 23 James. G. Schwade, M.D. announces the newly enhanced CyberKnife ... ( www.cyberknifemiami.com ). , The CyberKnife treatment for cancer ... cells with no invasive surgical incision. The length of the ... usually completed in 1- 5 treatments. , As the ...
... 20 percent get infected within one year of starting to ... News) -- As many as one in four U.S. teenage ... soon after their first sexual encounter, a new government report ... reminds us that we can,t ignore this," said study author ...
... is leading an initiative that could result in a paradigm ... Morehouse University School of Medicine and University of ... care physicians across Georgia to serve as "medical homes" for ... sends them to the hospital and seeking better prevention and ...
... , ... Instacare Corp. (OTC Bulletin Board: ISCR) announced today that its ... e-health technologies have been successfully engineered to seamlessly function on ... hand-held interactive medical software to the Apple iPhone, the Palm ...
... , NEW ORLEANS, Nov. 23 Thanksgiving weekend marks the 36th annual ... the sportsmanship and pride of two schools but it is so much ... in attendance. , For the crew of the new U.S. Coast Guard ... before they work to test and launch a brand new ship to ...
... ... and Automate Billing, Claims, Enrollment and Eligibility, , ... (PRWEB) November 23, 2009 -- BridgeGate ... the launch of new products within its healthcare integration suite, designed to help ...
Cached Medicine News:Health News:One in Four Teen Girls Have STDs 2Health News:One in Four Teen Girls Have STDs 3Health News:Initiative could result in paradigm shift in the care of sickle cell patients 2Health News:Initiative could result in paradigm shift in the care of sickle cell patients 3Health News:Initiative could result in paradigm shift in the care of sickle cell patients 4Health News:Initiative could result in paradigm shift in the care of sickle cell patients 5Health News:ISCR Becomes Instant Player in the Obamacare EMR/Cost Savings Sweepstakes 2Health News:ISCR Becomes Instant Player in the Obamacare EMR/Cost Savings Sweepstakes 3Health News:Nothing Is Like Being There 2Health News:BridgeGate Launches New Healthcare Integration and Interoperability Products 2Health News:BridgeGate Launches New Healthcare Integration and Interoperability Products 3Health News:BridgeGate Launches New Healthcare Integration and Interoperability Products 4
(Date:8/27/2014)...  Hill-Rom Holdings, Inc. (NYSE: HRC ) ... the Morgan Stanley Global Healthcare Conference on September 8, ... invited to listen to the live discussion via the ... directly at http://cc.talkpoint.com/morg007/090814a_ac/?entity=26_7CLOGQP .  A recorded replay of ... of the live event and accessible at the links ...
(Date:8/27/2014)... , Aug. 27, 2014 North American lighting ... prestigious R&D 100 Award for the new OSRAM ITOS ® ... LED-based white light module for microscopy, endoscopy and surgical head ... with significantly higher efficacy and lamp life. "We,re ... one of the most innovative new technologies of the past ...
(Date:8/27/2014)... , Aug. 27, 2014 Amgen (NASDAQ: ... Drug Administration (FDA) has granted priority review designation for ... Ivabradine is an oral drug that inhibits the ... sinoatrial node, the body,s cardiac pacemaker. 1 Ivabradine ... on myocardial contractility or ventricular repolarization. 1 Heart ...
Breaking Medicine Technology:OSRAM ITOS PHASER 3000 Laser and LED Light Module Recognized With Prestigious R&D 100 Award 2OSRAM ITOS PHASER 3000 Laser and LED Light Module Recognized With Prestigious R&D 100 Award 3FDA Grants Amgen Priority Review Designation For Ivabradine For The Treatment Of Chronic Heart Failure 2FDA Grants Amgen Priority Review Designation For Ivabradine For The Treatment Of Chronic Heart Failure 3FDA Grants Amgen Priority Review Designation For Ivabradine For The Treatment Of Chronic Heart Failure 4FDA Grants Amgen Priority Review Designation For Ivabradine For The Treatment Of Chronic Heart Failure 5FDA Grants Amgen Priority Review Designation For Ivabradine For The Treatment Of Chronic Heart Failure 6FDA Grants Amgen Priority Review Designation For Ivabradine For The Treatment Of Chronic Heart Failure 7
... 2011 Omthera Pharmaceuticals, Inc., a privately-held emerging ... President and Chief Executive Officer, will present at ... the Westin St. Francis Hotel in San Francisco, ... PT. About Omthera Pharmaceuticals, Inc.Founded ...
... Medical Technologies, Inc. today announced that Allina Hospitals ... company,s integrated electronic health record (EHR) practice management ... across Minnesota and western Wisconsin. ... ability to interface tightly with Allina,s Epic-based electronic ...
Cached Medicine Technology:Greenway's PrimeSUITE Endorsed by Allina Hospitals & Clinics 2Greenway's PrimeSUITE Endorsed by Allina Hospitals & Clinics 3
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: