Navigation Links
"Dynamic Energy Landscape" of enzyme in Catalysis

Complex protein molecules called enzymes catalyze specific biochemical reactions in cells. The traditional theory is that dynamic fluctuations//protein conformation or structure play a major role in enzyme catalysis. However, recent findings reveal that it is the "dynamic energy landscape" of the enzyme that directs it to a specific pathway that reduces the number and dimension of the energetic barriers to these catalytic changes. The study of the structure of the excited-state of protein may prove useful for drug design.

"There is a growing awareness that the inherent motions of proteins are essential to their functions," said Peter Wright, who is chair of the Scripps Research Department of Molecular Biology and a member of the Skaggs Institute for Chemical Biology at Scripps Research. "The importance of this study is that it reveals how dynamic structural fluctuations channel an enzyme through its reaction cycle-the thermal motions of the protein are harnessed to perform its biological function, in this case, catalysis. Knowledge of the excited-state conformations of proteins may offer new opportunities for drug design."

The researchers used nuclear magnetic resonance (NMR) to detect and characterize higher energy structural sub-states (excited states) of E. coli dihydrofolate reductase, which has been used extensively as a model enzyme for investigating the relations between structure, dynamics, and function in proteins. The researchers found that, at each stage in the catalytic cycle, the excited-state conformations resembled the ground-state structures of both the preceding and the following intermediates. This means that the dynamic fluctuations between the ground state and the excited state were "priming" the enzyme to take up the conformation of the adjacent intermediate state, facilitating the progress of catalysis by aiding the movement of ligands (molecules that bind to one chemical entity to form a larger complex) on and off the enzym
'"/>




Page: 1 2

Related medicine news :

1. Radiofrequency Energy Cooks Tumors Without Surgery
2. Energy intake directly related to portion size
3. Energy Therapy For Quicker Healing
4. Pollution Free Hydrogen based fuel for Energy
5. Obesity Can Be Caused By Consumption Of Energy Drinks
6. Bird Flu Likely To Reduce World Energy Demand
7. Alcohol-illusion: Alcohol and Energy Drinks Combo, Maintains Sobriety?
8. Energy Security Boosted by ADB in Asia
9. Boosting Energy Naturally
10. High-Energy Clamp Simplifies Heart Surgery for Atrial Fibrillation
11. Take A Walk To Boost Your Energy
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Dynamic Energy Landscape enzyme Catalysis

(Date:8/29/2014)... Angeles, CA (PRWEB) August 29, 2014 ... inspired others who talked about introducing these cutting ... experience as chairman of the FUE Research Committee has ... studies that redefine what is possible with modern technology. ... of a variety of FUE devices that facilitate extraction ...
(Date:8/29/2014)... 2014 According to a CNN article, ... (8/25), a new study found that those states ... seen a significant decrease in the number of painkiller ... ten year period, and comparing various states with and ... that there was about a 25% decrease in painkiller ...
(Date:8/29/2014)... (PRWEB) August 29, 2014 As reported by ... Monitoring For Drug Abuse Trends , Outbreaks (8/20), the National ... attempt to monitor drug abuse trends by turning to social ... drug abuse trends, it is also working with the University ... National Drug Early Warning System, which will be funded by ...
(Date:8/29/2014)... An article entitled How Genes, Gender and ... explains how genes, gender and the environment that an individual ... drugs. Researchers at Indiana University are taking another look at ... and are applying this factor to what is known about ... family and community ties can help to reduce a man’s ...
(Date:8/29/2014)... 29, 2014 Healthpointe is proud to ... Dr. Rodas will be practicing out of Healthpointe’s newest ... member of Healthpointe’s orthopedic team, Dr. Rodas ... and board-certified in occupational medicine. , Among Dr. ... Medical Director of Raytheon, the world-class defense and aerospace ...
Breaking Medicine News(10 mins):Health News:Parsa Mohebi M.D., Beverly Hills Hair Restoration Surgeon Gives Inspiring Lecture on Groundbreaking Techniques in Follicular Unit Extraction 2Health News:Overdoses on Painkillers Decreased in States With Medical Marijuana 2Health News:Overdoses on Painkillers Decreased in States With Medical Marijuana 3Health News:Social Media Proves to Be Helpful in Fighting Drug Abuse 2Health News:Social Media Proves to Be Helpful in Fighting Drug Abuse 3Health News:Substance Abuse Likelihood Affected by Environment, Gender and Genes 2Health News:Substance Abuse Likelihood Affected by Environment, Gender and Genes 3Health News:Dr. Anthony G. Rodas Joins Healthpointe Team at LAX Office 2
... in necessary prescriptions, study finds , , TUESDAY, Feb. 3 ... "doughnut hole" in the Medicare Part D drug plan ... with an employer-based plan, a new study finds. , ... costs from hospitalizations and doctor visits resulting from this ...
... Ala. Exposure to second-hand smoke and alcohol significantly ... at the University of Alabama at Birmingham (UAB). , ... and alcohol are worse for health as a combination, ... an associate professor in the UAB Department of Environmental ...
... Group, Inc.,(NYSE Alternext US: QGP) ( www.QuantumMD.com ) announced ... debut at the 2009 Pri-Med,South Conference and Expo alongside ... Quantum believes PWeR is the next generation in healthcare ... Obama is calling for within,the industry. Pete Martinez, ...
... A thesis from the Sahlgrenska Academy, University of Gothenburg, ... suicide attempt are five times more likely to attempt ... nightmares. , The study included 165 patients aged ... psychiatric departments following a suicide attempt in Sweden. Psychiatric ...
... Feb. 3 Physicians have been raving about the ... 2008 survey of U.S. VASER Lipo physicians, 95% of ... physician or facility. The VASER Lipo System ... contouring applications from precise sculpting to significant fat removal."Hundreds ...
... improve writing skills for those with aphasia with the aid ... doctoral thesis from the Sahlgrenska Academy at the University of ... use spoken language, and the ability to read and write. ... writing aids in the study on which speech and language ...
Cached Medicine News:Health News:Medicare Drug Plan 'Doughnut Hole' Could Impact Seniors' Health 2Health News:Tobacco smoke and alcohol harm liver worse as combo 2Health News:PWeR(TM) Introduced at Regional Healthcare Conference 2Health News:PWeR(TM) Introduced at Regional Healthcare Conference 3Health News:PWeR(TM) Introduced at Regional Healthcare Conference 4Health News:Nightmares increase risk of further suicide attempts 2Health News:THE RESULTS ARE IN! VASER(R) Lipo Receives 95% Approval Rating by Physician Users 2Health News:Computerized writing aids make writing easier for persons with aphasia 2
(Date:8/29/2014)... -- ChemImage will present a workshop focused on hyperspectral ... Science Society,s 22 nd International Symposium on ... .  Forensic Scientists will be in attendance ... can bring to examination procedures. ... Development at ChemImage, will host a workshop during ...
(Date:8/29/2014)... VANCOUVER, British Columbia and MENLO ... -- DelMar Pharmaceuticals, Inc. (OTCQB: DMPI) ("DelMar" ... 2014 fiscal year-end financial statements.  The Company recently changed ... to facilitate an application to list its common stock ... possible. DelMar,s financial statements as filed with ...
(Date:8/28/2014)... Aug. 28, 2014 Reportlinker.com announces that ... its catalogue: North America Aesthetic Lasers ... http://www.reportlinker.com/p02343466/North-America-Aesthetic-Lasers-and-Energy-Devices-Market-Outlook-to-2020.html North ... to 2020 Summary GlobalData,s new report, ... Outlook to 2020", provides key market data on ...
Breaking Medicine Technology:ChemImage to Discuss Hyperspectral Imaging for Forensic Investigation at the ANZFSS 22nd International Symposium on the Forensic Sciences 2ChemImage to Discuss Hyperspectral Imaging for Forensic Investigation at the ANZFSS 22nd International Symposium on the Forensic Sciences 3DelMar Pharmaceuticals Fiscal 2014 Year End Results and Summary of Recent Developments 2DelMar Pharmaceuticals Fiscal 2014 Year End Results and Summary of Recent Developments 3DelMar Pharmaceuticals Fiscal 2014 Year End Results and Summary of Recent Developments 4DelMar Pharmaceuticals Fiscal 2014 Year End Results and Summary of Recent Developments 5North America Aesthetic Lasers and Energy Devices Market Outlook to 2020 2North America Aesthetic Lasers and Energy Devices Market Outlook to 2020 3North America Aesthetic Lasers and Energy Devices Market Outlook to 2020 4North America Aesthetic Lasers and Energy Devices Market Outlook to 2020 5North America Aesthetic Lasers and Energy Devices Market Outlook to 2020 6North America Aesthetic Lasers and Energy Devices Market Outlook to 2020 7North America Aesthetic Lasers and Energy Devices Market Outlook to 2020 8North America Aesthetic Lasers and Energy Devices Market Outlook to 2020 9North America Aesthetic Lasers and Energy Devices Market Outlook to 2020 10North America Aesthetic Lasers and Energy Devices Market Outlook to 2020 11North America Aesthetic Lasers and Energy Devices Market Outlook to 2020 12North America Aesthetic Lasers and Energy Devices Market Outlook to 2020 13North America Aesthetic Lasers and Energy Devices Market Outlook to 2020 14North America Aesthetic Lasers and Energy Devices Market Outlook to 2020 15North America Aesthetic Lasers and Energy Devices Market Outlook to 2020 16
... segment surgical procedures. For dissection of vitreoretinal ... luer lock tubing set is attached to ... - .02in (.50mm); OD - .06in (1.5mm) ... viscoelastic fluids. 30G (.30mm) tip, flattened. Angled ...
Product designed specifically for posteror segment surgical procedures. Facilitates posterior segment infusion. Flexible tubing 10in (25cm)....
For surgical treatment, repair and irrigation of the nasolacrimal system. Silicone tubing. Length 14in (35cm) ID: .012in (.30mm) OD: .025in (.60mm)...
...
Medicine Products: