Navigation Links
Why African-Americans are at greater risk of hypertension and kidney disease
Date:7/13/2009

NEW YORK (July 13, 2009) -- Physician-scientists from NewYork-Presbyterian Hospital/Weill Cornell Medical Center believe that a heightened level a certain growth factor in the blood may explain why blacks have a greater prevalence of hypertension and kidney disease compared to whites. Results from a new study are the first to show that an elevated level of a protein, called transforming growth factor B1 (TGF-B1), raises the risk of hypertension and renal disease in humans.

African Americans constitute about 32 percent of all patients treated for kidney failure in the U.S. and are four times more likely to develop renal disease than whites, according to the National Institutes of Health's U.S. Renal Data System. The researchers' findings, published in this month's issue of the journal Kidney International, may someday lead to the development of a new class of anti-hypertensive and kidney disease drugs that target the TGF-B1 protein.

"I believe we may now understand a great puzzle: why the black population has a greater prevalence of hypertension and kidney disease," says Dr. Manikkam Suthanthiran, first author of the study and attending physician at NewYork-Presbyterian/Weill Cornell, Stanton Griffis Distinguished Professor of Medicine, Professor of Biochemistry and Professor of Medicine in Surgery at Weill Cornell Medical College.

Results from the study revealed that the TGF-B1 protein was significantly higher in 186 black study participants compared with 147 white participants.

After controlling for race, sex and age, TGF-B1 protein levels were highest in hypertensive blacks (46 ng/ml). Non-hypertensive blacks also had higher levels (42 ng/ml) compared to hypertensive whites (40 ng/ml) and non-hypertensive whites (39 ng/ml), demonstrating that even healthy black patients may be at higher risk for future hypertension and renal disease compared to healthy and hypertensive whites.

"Many black patients may have
'/>"/>

Contact: Limda Kamateh
lib9027@med.cornell.edu
212-821-0560
New York- Presbyterian Hospital/Columbia University Medical Center
Source:Eurekalert

1

GOOD

Page: 1 2

Related medicine news :

1. What is different in reflux esophagitis between African-Americans and non-Hispanic whites?
2. Grammy-nominated Singer Angie Stone Encourages African-Americans in Birmingham to Fearlessly FACE Diabetes
3. Hormone linked to high blood pressure and blood vessel disease in African-Americans
4. Childrens Hospital study finds African-Americans more distrusting of research than whites
5. African-Americans have worse prognosis at colorectal cancer diagnosis
6. Fear, misconceptions about screenings keep many African-Americans from getting mammograms
7. MYH9 gene variations help explain high rate of kidney disease in African-Americans
8. American Diabetes Association and Eli Lilly and Company Unite to Educate and Empower African-Americans with Diabetes
9. Newly found gene variants account for kidney diseases among African-Americans
10. Kidney disease worsens in a fourth of African-Americans despite therapy for hypertension
11. New Survey Shows African-Americans Are Concerned With Heart Health but Unaware of Link to Brain Health
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/22/2013)... CoCENTRIX, a leading provider of coordinated ... Services and community providers, announced today that the ... CoCENTRIX Coordinated Care Platform (CoCENTRIXccp) as ... and coordinate care within and amongst its four ... transitioning the hospitals' official records from paper-based to ...
(Date:5/22/2013)... Denver, CO (PRWEB) May 22, 2013 ... of legal discovery management services for law firms, corporations ... Cumulus Data, Inc., a cloud-based e-discovery software company, to ... of this newly formed partnership, Cumulus Data and LDM ... Standard, downtown LA on Tuesday, May 21st. This ...
(Date:5/22/2013)... 2013 BroadConnect Telecom, the leading ... security solutions in North America announced plans to ... newest BroadConnect hosted security solutions. Available on premise, ... BroadConnect’s new Security as a Service (SaaS) enables ... connection of their choice, while optimizing internal network ...
(Date:5/22/2013)... Poor adherence to appropriate medication therapy has ... and death (some 125,000 deaths in the U.S. every ... costs. It’s been estimated that between 33% and 69% ... medication adherence — a reality that costs the American ... dire is the degree of medication non-adherence — and ...
(Date:5/22/2013)... Dallas, TX (PRWEB) May 22, 2013 Mari’s ... in Dallas, has become the first in the state of ... is called Meta Therapy- Medical and Esthetic Tissue Activation, also ... used for over four years in Europe, but has just ... Meta Therapy improves the skin from inside out by building ...
Breaking Medicine News(10 mins):Health News:The State of Alabama Selects the CoCENTRIX Coordinated Care Platform to Facilitate Care for Its Citizens Treated in State Psychiatric Hospitals 2Health News:The State of Alabama Selects the CoCENTRIX Coordinated Care Platform to Facilitate Care for Its Citizens Treated in State Psychiatric Hospitals 3Health News:LDM Global Enhances Forensic Data Collection Services with eCloudCollect 2Health News:LDM Global Enhances Forensic Data Collection Services with eCloudCollect 3Health News:BroadConnect Telecom to Launch Enterprise-Grade Hosted Security Solutions Engineered to Meet the Demands of Real World Business 2Health News:Patient Prompt® Announces New Drug Adherence Program to Assist in Prescribed Medication Compliance 2Health News:Mari's to Offer New Treatment from Europe 2
... Government medical services in Andhra Pradesh came to ... indefinite// strike enters the second day. ,Patients ... emergency services. Patients seeking immediate medical assistance had ... prevailed at the Osmania General Hospital and the ...
... about the hearing loss caused by the MP3 players, ... paying// any heed to those warnings. But sensing the ... limiting the volume on the devices. ,The American ... to the ears associated with MP3 players. The ASHA ...
... A relatively new kind of antibiotic has been found to ... is necessary// before the drug can be prescribed, says a ... around the world, causes inflammation of the airways, or bronchi, ... thereby disrupting breathing. ,During an asthmatic attack, the ...
... Special K Snack Bites are Kellogg’s latest additions to ... on-the-go consumer//. ,The Granola Munch'ems snack bites ... and minerals such as Vitamin A, Vitamin B6, Thiamin, ... available as bite-sized-morsels in individual pouches which are available ...
... new research, men who have elevated levels of testosterone ... but may lead shorter lives// when compared with men ... ,According to foodconsumer.org, comparative studies have studied testosterone levels ... very few studies have attempted to relate testosterone to ...
... of Prestbury Avenue, Newcastle-under-Lyme, Staffs, was found not guilty of ... the manslaughter of a baby who died of head injuries ... Crown Court took five hours to reach their verdict. Passing ... the family. ,Dr El-Khadem an Egyptian by birth ...
Cached Medicine News:Health News:Doctors Strike In Andhra Enters The Second Day 2Health News:Sensing The Health Hazard MP3 Makers Tone Down The Volume 2
(Date:5/22/2013)... , May 22, 2013  Grifols, a global ... , presented results from a study demonstrating that a ... Inhibitor [Human]) increased levels of the alpha 1 ... to levels that are considered within the normal range ... condition in which low levels of the alpha 1 ...
(Date:5/22/2013)... , May 22, 2013  BD (Becton, Dickinson ... global medical technology company, announced today the publication of ... fifth Sustainability Report and it continues to focus on ... "We believe the principles of shared value — ... healthcare challenges of societies — are fundamental to our ...
(Date:5/22/2013)... , May 22, 2013 Rigel Pharmaceuticals, Inc. ... advancement of three programs in development. The first program ... inhibitor, R348, being developed by Rigel as a treatment ... aimed at oncology targets and are being conducted by ... by BerGenBio AS (BerGenBio) and a ligase inhibitor under ...
Breaking Medicine Technology:Grifols study demonstrates higher dose of PROLASTIN-C increases levels of alpha1-PI to within normal range in patients with AAT deficiency 2Grifols study demonstrates higher dose of PROLASTIN-C increases levels of alpha1-PI to within normal range in patients with AAT deficiency 3Grifols study demonstrates higher dose of PROLASTIN-C increases levels of alpha1-PI to within normal range in patients with AAT deficiency 4BD Issues 2012 Sustainability Report 2BD Issues 2012 Sustainability Report 3Rigel's R348 to Initiate Phase 2 Clinical Trial in Dry Eye 2Rigel's R348 to Initiate Phase 2 Clinical Trial in Dry Eye 3Rigel's R348 to Initiate Phase 2 Clinical Trial in Dry Eye 4
... YORK, Jan. 11, 2011 Reportlinker.com announces that ... its catalogue: Advanced Drug Delivery ... http://www.reportlinker.com/p0358466/Advanced-Drug-Delivery-Markets-Liposomes-Polymers-and-Monoclonal-Antibodies.html Drug delivery ... drug product formulations being discovered frequently. Advanced drug ...
... NEW YORK, Jan. 11, 2011 Reportlinker.com announces ... in its catalogue: Innovative Drug ... http://www.reportlinker.com/p0359990/Innovative-Drug-Discovery-in-Emerging-Markets.html Introduction Emerging markets ... pharmaceutical industry, but it has been unclear the ...
Cached Medicine Technology:Reportlinker Adds Advanced Drug Delivery Markets (Liposomes, Polymers and Monoclonal Antibodies) 2Reportlinker Adds Advanced Drug Delivery Markets (Liposomes, Polymers and Monoclonal Antibodies) 3Reportlinker Adds Innovative Drug Discovery in Emerging Markets 2Reportlinker Adds Innovative Drug Discovery in Emerging Markets 3
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
Medicine Products: