Navigation Links
Warning signs predict kidney injury after surgery
Date:8/11/2011

Washington, DC (August 12, 2011) Acute kidney injury (AKI) is a common but preventable -- complication after surgery that can lead to other complications or even death. The use and development of biomarkers will help physicians diagnose and treat acute kidney injury. Three protein measurements indicate who has a high risk of developing kidney injury after heart surgery, according to two studies appearing in an upcoming issue of the Journal of the American Society of Nephrology.

"To date, these are the largest studies in adults and children comparing and validating the performance of three of the most frequently studied markers of kidney injury," said author Chirag Parikh, MD, PhD (Yale University School of Medicine).

The studies included more than 1,200 adults and 300 children undergoing heart surgery throughout North America. Frequent urine and blood samples were collected to measure levels of three proteins -- urine interleukin-18 (IL-18) and urine and plasma (blood) neutrophil gelatinase-associated lipocalin (NGAL)and assess their ability to predict who will develop kidney injury after surgery.

Traditionally, kidney trouble is assessed by measuring the blood protein creatinine, which is not ideal because it has a delayed resultit does not pick up early damage and injury to the kidneys.

"We demonstrated that the three proteins in our study identify kidney injury soon after surgery and 24 to 48 hours earlier than creatinine, and shows a similar result," according to Parikh.

Risk of kidney injury was especially highmore than six times higherfor adults and children with the highest levels of urine IL-18. Plasma NGAL also predicted kidney injury in adults, whereas urine NGAL was not an accurate predictor in adults once results were adjusted for other factors. Urine IL-18 and urine, but not plasma, NGAL were accurate predictors in children.

Doctors may wish to measure these urine or blood proteins immediately after surgery to predict which patients are at high risk of developing kidney injury. These patients might benefit from kidney protective therapies.

The studies' results could also transform the diagnosis of kidney disease, Parikh believes. "Developing markers of structural kidney damage, before kidney function fails, is a top priority," he said.

The research's main limitation was that the adults enrolled were mainly Caucasian. Future studies should consider whether the results are the same in other races.


'/>"/>

Contact: Adrienne Lea
alea@asn-online.org
202-503-6560
American Society of Nephrology
Source:Eurekalert

Related medicine news :

1. American Heart Association Rapid Access Journal Report: Study Finds Racial Gaps Continue in Heart Disease Awareness, Low Knowledge of Heart Attack Warning Signs Among Women
2. Connecticut Board Considers Warning About Risk Of Stroke Following Chiropractic Neck Manipulation
3. FDA Issues Warning on Key Asthma Drugs
4. Warning: Immigrating to North America may foster smoking in children
5. UNC study: Obese 3-year-olds show early warning signs for future heart disease
6. A Warning to Negligent Apartment Building Landlords in New York From Personal Injury Lawyer, David Perecman
7. Americans for Responsible Health Care Launch Radio Ads Targeting Seven Democrats, Warning The People Are Watching...
8. Not All Slings Are Created Equally: Baby Sling & Carrier Manufacturers Speak Out On Baby Sling Safety Warning
9. FDA Issues Warning on Fat-Melting Spa Injections
10. Warning Over Dangers of Used Racking Issued By Thistle Systems
11. Normal Blood Pressure in Male Teens a Warning Sign
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/8/2016)... ... December 08, 2016 , ... The Dan Carlisle ... in Jefferson County, is announcing the launch of a charity drive to raise ... of homeless women and children in Birmingham has grown steadily since the 1980’s, ...
(Date:12/8/2016)... ... 08, 2016 , ... The Compretta Insurance Agency, a family owned insurance and ... the Hancock County area, is announcing the launch of a charity effort aimed at ... County Food Pantry has worked for more than 30 years to meet the food ...
(Date:12/7/2016)... OF PRUSSIA, PA (PRWEB) , ... December 07, 2016 , ... ... clinical trials with the announcement that it is one of the early adopters completing ... Privacy Shield Framework is designed to provide companies on both sides of the Atlantic ...
(Date:12/7/2016)... Wisconsin (PRWEB) , ... December 07, 2016 , ... Kenall ... extraordinary new MedMaster™ MPCNGX . The MPCNGX is a multi-function, sealed, LED luminaire ... right amount of light where and when it’s needed. , A 2’ ...
(Date:12/7/2016)... ... December 07, 2016 , ... Wavelink, an industry leader ... through a new partnership with Splashtop Inc. This remote control for Android extends ... help businesses maximize their uptime and productivity. , Wavelink offers powerful enterprise mobility ...
Breaking Medicine News(10 mins):
(Date:12/8/2016)... -- Boehringer Ingelheim announced today that it has been recognized ... the ninth time that the company received a perfect ... to Work for LGBT Equality. Administered by the Human ... report on corporate policies and practices related to workplace ... "We are committed to creating an ...
(Date:12/8/2016)... , Dec. 8, 2016  Avelas Biosciences, ... improving cancer patient care from diagnosis through treatment, ... recently completed Phase 1b study in breast cancer ... San Antonio Breast Cancer Symposium. Jonathan Unkart ... at UC San Diego Health, delivered the presentation ...
(Date:12/8/2016)... 2016  Hanson Research, an innovative leader in ... diffusion testing instruments for the pharmaceutical industry, announced ... Inc. ("Teledyne"). The move is designed to deepen ... instruments, as well as expand resources for further ... and services. Logo - http://photos.prnewswire.com/prnh/20161208/446988LOGO ...
Breaking Medicine Technology: