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University of Cincinnati researchers win $3.7M grant from US Department of Defense
Date:4/17/2012

cadian rhythms, cell cycle, DNA damage response and metabolism) using the filamentous (thread-like) fungi Neurospora crassa, and second, to establish general principles of coupled network dynamics from Neurospora and apply those principles to mammalian intestinal cell lines.

Researchers say the studies will elucidate potential methods to improve care for patients with abdominal trauma or exposure to gut pathogens.

Experimentally validated mathematical models from Neurospora will be used to make predictions in other Neurospora mutant strains and mammalian intestinal cells, focusing on responses to injury and nutritional deprivation.

"Each cellular mechanism is complex with multiple feedback loops," says Hong. "Therefore, we will use mathematical and statistical modeling to investigate network dynamics arising from these interlinked cellular responses."


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Contact: Keith Herrell
keith.herrell@uc.edu
513-558-4559
University of Cincinnati Academic Health Center
Source:Eurekalert

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