UCLA scientists create army of tumor-fighting immune cells and watch as they att... (id Geffen School of Medicine and first a...)

Navigation Links

Biology News Medicine News Biology Products Medicine Products Biology Definition Medicine Definition Biology Technology Medicine Technology Biology Dictionary Medicine Dictionary

HOME >> MEDICINE >> NEWS

UCLA scientists create army of tumor-fighting immune cells and watch as they attack cancer

Date:7/12/2010

id Geffen School of Medicine and first author of the study. "We were also gladly surprised to see the targeted tumors literally melt away and disappear, underscoring the power of the combined approach of immune and gene therapy to control cancer."

The immune system generally does not recognize cancer cells in the body as enemies. The insertion of the antigen-specific T cell receptors engineered to seek out a tumor antigen on the surface of the melanoma cells in effect uncloaks the malignant cells, revealing them as deadly invaders that must be sought out and killed.

By imaging the genetically engineered T cells as they seek out and attack the cancer, the scientists can closely examine the processes of the immune system as it fights malignancies , which could then result in better monitoring response to therapy in melanoma patients.

In this study, the cells were injected into the bloodstreams of the mice and they had found and begun to fight the melanoma within two to three days. The mice were imaged periodically for 10 days to ensure the lymphocytes were indeed killing the cancer. The process to find and kill the malignant cells could take longer in people, Ribas said.

If a patient's tumor did not respond well to the administration of the genetically engineered T cells, scientists could determine by PET scanning whether the cells had not successfully made it to the tumor site or, if they did arrive, whether or not they functioned as expected. Monitoring the immune response also could provide clues on ways to better engineer the lymphocytes to more effectively enter and attack the tumors.

In this study, about one million genetically engineered lymphocytes were created and injected into a mouse. In humans, the number of tumor-seeking cells needed to fight the cancer is about one billion, Ribas said.

Ribas and his team are working now on creating a vector, or vehicle, to insert the T cell receptors and report
'/>"/>

Contact: Kim Irwin
kirwin@mednet.ucla.edu
310-206-2805
University of California - Los Angeles
Source:Eurekalert

0

GOOD

Page: 1 2 3
Related medicine news :

1. Scientists reprogram triple-negative breast cancer cells to respond to tamoxifen
2. Scripps Research scientists uncover previously unknown natural mechanism that controls cocaine use
3. Scientists design new delivery device for gene therapy
4. With magnetic nanoparticles, scientists remotely control neurons and animal behavior
5. Scientists find link between estrogen metabolism pathway and breast cancer risk
6. Scientists Spot Gene Variants That Predict Longevity
7. Damon Runyon and Doris Duke Foundations announce partnership to support physician-scientists
8. Scripps Research scientists share $2 million in Florida state research grants
9. Melanoma-initiating cell identified by Stanford scientists
10. Scientists Fashion New Lung for Rats
11. Scientists Tease Out Links Between Diabetes, Cancer

Post Your Comments:

(Date:5/21/2013)... 21, 2013 Dr. Francine Kaufman , inventor ... used with her patients in the 1980s: It weighed several pounds ... the most part, it could only be used in the hospital ... since then, and the advantages are greater as well. The insulin ... of the body, often on a belt or a pocket. It ...

(Date:5/21/2013)... Atlanta, GA (PRWEB) May 21, 2013 ... Care, ScripNet and Procura Management, today announced that ... Award at Catamaran’s client advisory meeting. Conferred ... has partnered with Catamaran to create cutting edge ... This year, Healthcare Solutions was recognized for its ...

(Date:5/21/2013)... Healthcare industry leaders, health information technology startups, and ... Emerging Healthcare Technology Conference, June 10 at the Fluno ... new event is part of the 11th annual Digital ... being held June 10-12 at the Fluno Center for ... for healthcare information technology (IT) grew dramatically in 2012 ...

(Date:5/21/2013)... 21, 2013 Two-thirds of patients who ... lung cancer reported that they engage in at least ... according to new findings from the National Health ... Health . The research will be presented today at ... for Pharmacoeconomics and Outcomes Research) in New Orleans. ...

(Date:5/21/2013)... May 21, 2013 The producers of ... air dates for Peterborough, Ontario, Canada. The area is famous ... for Canadians and Americans. It is located an hour from ... Peterborough is located in the Kawartha Hills, home to several ... economic stability to the area. Residents and visitors to this ...

Breaking Medicine News(10 mins):Health News:Kaufman Shows People With Diabetes How to Use New Technology to Improve Their Lives 2 Health News:Kaufman Shows People With Diabetes How to Use New Technology to Improve Their Lives 3 Health News:Kaufman Shows People With Diabetes How to Use New Technology to Improve Their Lives 4 Health News:Healthcare Solutions Receives Innovation Award From Catamaran 2 Health News:“Start Me Up" Healthcare Conference: Where Healthcare CIOs, Entrepreneurs and Investors Meet 2 Health News:Two in Three Cancer Patients are Non-Adherent with Their Medications, According to Kantar Health Research 2 Health News:Two in Three Cancer Patients are Non-Adherent with Their Medications, According to Kantar Health Research 3 Health News:Net Worth Business TV Announces May Air Dates for Peterborough, Ontario 2

[0] Kaufman Shows People With Diabetes How to Use New Technology to Improve Their Lives [0] Healthcare Solutions Receives Innovation Award From Catamaran [0] “Start Me Up" Healthcare Conference: Where Healthcare CIOs, Entrepreneurs and Investors Meet [0] Two in Three Cancer Patients are Non-Adherent with Their Medications, According to Kantar Health Research [0] Net Worth Business TV Announces May Air Dates for Peterborough, Ontario

... Annual Dinner, May 17, DETROIT, Jan. 31 ... its nurse paging system, thanks to the,generosity of ... vice,president of development for the Institute., (Logo:, ... our 26th Annual Dinner May 17, Ford Motor ...

... Long-time local partners cite proprietary research, strategic planning and ... superior creative as keys to their success, ... two major,national advertising awards at the Consumer Health World Conference ... have again taken top honors in a national awards program., ...

... once looked at for cancer, also attacks the human immunodeficiency ... research published today online in the open access journal Retrovirology. ... learned to hide out in certain human cells where it ... serve as viral reservoirs. Operating from these havens, the virus ...

... ABAX ), a medical products company manufacturing point-of-care,blood analysis ... 31, 2007., Highlights for the third ... $25.7 million, up 17% over last year,s comparable quarter. ... over last year,s comparable quarter. ...

... Separate Research Confirms Part D Seniors Also Enjoy Broad ... Pharmaceutical Care,Management Association (PCMA) issued the following statement on ... drug benefit is lower over the,next ten years than ... saving money without sacrificing beneficiaries,choice of prescription drugs. New ...

... of its ongoing efforts to do whatever it takes ... for Parkinson,s disease, The Michael J. Fox Foundation for ... total funding to four industry teams seeking to push ... awards were granted under MJFF,s Therapeutics Development Initiative (TDI) ...

Ford Motor Company Fund Continues Longtime Support to Cancer Care St.Vincent and Publicis Indianapolis Receive National Service Industry Advertising Awards Anti-parasite drug may provide new way to attack HIV Abaxis Reports Record Sales for the Third Quarter of Fiscal 2008 CMS: Part D Costs $117 Billion Lower Than Expected Michael J. Fox Foundation awards up to $3 million to industry teams

(Date:5/21/2013)... 2013 Zacks.com announces the list of stocks featured ... Research analysts discuss the latest news and events impacting ... the blog include Actavis, Inc.,s (NYSE: ACT ), ... TOT ), Petrobras (NYSE: PBR ) and ... (Logo: http://photos.prnewswire.com/prnh/20101027/ZIRLOGO ) Get the ...

(Date:5/21/2013)... 21, 2013 Decision Resources, one of ... for pharmaceutical and healthcare issues, finds that ... key efficacy endpoints, including overall survival and ... influence over surveyed U.S. and European oncologists, ... HER2-negative breast cancer. The two novel emerging ...

(Date:5/21/2013)... 2013 Armada Health Care (Armada) is pleased ... corporate website ( www.armadahealthcare.com ). This new website ... first-to-market services and its position as the leading ... pharmacy industry. The updated website visibly ... model in delivering an extensive portfolio of services ...

Breaking Medicine Technology:The Zacks Analyst Blog Highlights: Actavis, BP, Total, Petrobras and Devon Energy 2 The Zacks Analyst Blog Highlights: Actavis, BP, Total, Petrobras and Devon Energy 3 The Zacks Analyst Blog Highlights: Actavis, BP, Total, Petrobras and Devon Energy 4 The Zacks Analyst Blog Highlights: Actavis, BP, Total, Petrobras and Devon Energy 5 Thought-Leader Opinion and Clinical Data Indicate that Emerging Agents from Two Drug Classes Have Efficacy Advantages Over Currently Used Therapies for HR-Positive, HER2-Negative Breast Cancer 2 Armada Announces New Corporate Website to Showcase Expanded Services to Specialty Pharmacy Marketplace 2

[0] The Zacks Analyst Blog Highlights: Actavis, BP, Total, Petrobras and Devon Energy [0] Thought-Leader Opinion and Clinical Data Indicate that Emerging Agents from Two Drug Classes Have Efficacy Advantages Over Currently Used Therapies for HR-Positive, HER2-Negative Breast Cancer [0] Armada Announces New Corporate Website to Showcase Expanded Services to Specialty Pharmacy Marketplace

... Results from the Phase II portion of a ... for the treatment of acute heart failure will be ... at the American College of Cardiology,s (ACC) 58th Annual ... of medicine, University of California San Francisco , ...

... Will Test Ability of Adecatumumab to Prolong Disease ... MetastasesBETHESDA, Md., March 23 Micromet, ... company developing novel, proprietary antibodies for the treatment ... the commencement of a randomized, controlled phase 2 ...

Cached Medicine Technology:Results From Efficacy and Safety Study of Corthera's Relaxin in Acute Heart Failure to be Presented at Late-Breaking Clinical Trials Session at ACC 58th Annual Scientific Session 2 Micromet Has Started a New Phase 2 Trial with Adecatumumab in Colorectal Cancer Patients 2 Micromet Has Started a New Phase 2 Trial with Adecatumumab in Colorectal Cancer Patients 3 Micromet Has Started a New Phase 2 Trial with Adecatumumab in Colorectal Cancer Patients 4 Micromet Has Started a New Phase 2 Trial with Adecatumumab in Colorectal Cancer Patients 5

Results From Efficacy and Safety Study of Corthera's Relaxin in Acute Heart Failure to be Presented at Late-Breaking Clinical Trials Session at ACC 58th Annual Scientific Session Micromet Has Started a New Phase 2 Trial with Adecatumumab in Colorectal Cancer Patients

...

Tip is bent towards port for downward irrigation. 25G x 5/8in (.50 x 22mm)...

... product designed for LASIK surgery and other ... the corneal interface and/or stromal bed. Flattened ... and helps elevate the flap edge. Multiple ... G (.40 x 22mm). Angled 90 degrees, ...

... LASIK surgery and other types of ... corneal interface and/or stromal bed. Flattened ... flap and helps elevate the flap ... 23G x 7/8in (.60 x 22mm) ...

Medicine Products:

Hydrodissector - Daya Irrigating Cystotome - Reverse Lasik Irrigator - Probst Lasik Spatula/Irrigator