Navigation Links
Tobacco-derived compound prevents memory loss in Alzheimer's disease mice
Date:4/27/2011

hers administered cotinine daily for five months to young adult (2-month-old) mice genetically altered to develop memory problems mimicking Alzheimer's disease as they aged. At the end of the five-month study, the Alzheimer's mice treated with cotinine performed better on tasks measuring their working memory and thinking skills than untreated Alzheimer's control mice. Long-term cotinine treatment appeared to provide the Alzheimer's mice complete protection from spatial memory impairment; their performance in this area of testing was identical to that of normal mice without dementia.

The brains of Alzheimer's mice treated with cotinine showed a 26-percent reduction in deposits of amyloid plaques, which are a hallmark of Alzheimer's disease. Cotinine also inhibited the accumulation of the amyloid peptide oligomers a predecessor of senile plaques in the brains of these mice. Furthermore, the researchers discovered that cotinine stimulated the signaling factor Akt, which promotes the survival of neurons and enhances attention and memory.

Senile plaques likely had not yet formed or were just beginning to accumulate in the brains of the young adult mice when long-term cotinine treatment was started. The researchers suggest that "cotinine may be useful in preventing cognitive deterioration when administered to individuals not yet exhibiting Alzheimer's disease cognitive impairment or those with mild cognitive impairment at early stages of the disease."

The researchers are seeking additional support for a pilot clinical trial to investigate cotinine's effectiveness in preventing progression to Alzheimer's dementia in patients with mild cognitive impairment, Echeverria said.

The VA-USF team is also studying the potential of the tobacco-derived compound to relieve fear-induced anxiety and help blunt traumatic memories in mouse models of post-traumatic stress disorder.


'/>"/>

Contact: Anne DeLotto Baier
abaier@health.usf.edu
813-974-3300
University of South Florida (USF Health)
Source:Eurekalert  

0

GOOD

Page: 1 2

Related medicine news :

1. UGA compound offers new hope for treatment of painful adult shingles
2. Scientists develop compound that effectively halts progression of multiple sclerosis
3. New study finds compounds show promise in blocking STAT3 signaling as treatment for osteosarcoma
4. High levels of toxic compounds found on coasts of West Africa
5. Good news for meat lovers: Most ready-to-eat meat products contain very few cancerous compounds
6. Researchers develop synthetic compound that may lead to drugs to fight pancreatic, lung cancer
7. Scripps Research and MIT scientists discover class of potent anti-cancer compounds
8. Compound used to block cholesterol could also kill breast cancer, MU researcher finds
9. Red wine compound increases anti-tumor effect of rapamycin
10. Scripps Research compound blocks brain cell destruction in Parkinsons disease
11. Bioactive compounds in berries can reduce high blood pressure
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Tobacco-derived compound prevents memory loss in Alzheimer's disease mice
(Date:6/19/2013)... Tornadoes and their devastating aftermath have increased across the ... to these deadly storms find it hard to recover. ... and corporations from natural and man-made disasters for over ... philosophy of providing a storm shelter that can be ... stand up, with light and a battery-operated blower for ...
(Date:6/19/2013)... Washington, DC (PRWEB) June 19, 2013 ... experiment in the history of managed care. As ... find coverage through the new state-based and federally ... requirements for essential health benefits, and examples of ... some states, industry-leading health business information publisher Atlantic ...
(Date:6/19/2013)... York, NY (PRWEB) June 19, 2013 ... Law Group LLP highlights a recent news story from ... alleged side effects of the hormone-based contraceptive device. The ... those looking to file Mirena lawsuits and ... effects. , The U.S. Food and Drug Administration has ...
(Date:6/19/2013)... (PRWEB) June 19, 2013 As more ... they want to use green energy-saving products to replace ... manufacturer of LED lights, produces a variety of products ... LED bulbs, LED flood light, and LED spot ... down light [ZT-D70-311F] is introduced to customers by Zhongtian ...
(Date:6/19/2013)... (PRWEB) June 19, 2013 Men often deal ... not pay close attention to what they are consuming on ... June, the leading producer and supplier of Siberian pine nut ... of the all-natural healing elements within pine nut ... are the most common ulcers within the gastrointestinal tract that ...
Breaking Medicine News(10 mins):Health News:Radius Engineering International Inc. Tornado-Resistant Storm Shelters 2Health News:New Special Report Provides Comprehensive Overview of New Health Insurance Exchange Marketplaces 2Health News:Rottenstein Law Group LLP Comments on News Reports of Mirena IUD Side Effects 2Health News:3W High Power LED Down Light [ZT-D70-311F] Is Introduced to Customers by Zhongtian Lighting 2Health News:Pine Nut Oil is a Proven Remedy for Stomach Ulcers 2
... The American School,Health Association, the National Association of ... today joined together to create,one voice to urge ... Prevention,and Tobacco Control Act, which would give the ... three associations, each formed to assist the Nation,s ...
... representatives are invited,to a photo opportunity with the Honourable ... Governor, in light of an,international collaboration announcement on cancer ... Convention in San Diego., Who: ... Arnold Schwarzenegger, The ...
... Inc.,(Nasdaq: HOLX ) today announced that Glenn Muir, ... Annual Healthcare Conference being,held June 24 - 26, 2008, ... Interested parties are invited to listen to a ... 25, 2008, at 12:30 PM.,Eastern Time on the investor ...
... also express concern about psoriasis drug,s possible risks for ... strengthening , , WEDNESDAY, June 18 (HealthDay News) -- ... Wednesday that the psoriasis drug Enbrel be approved for ... skin disease. , The outside medical experts, in a ...
... higher annual volumes of patients with inflammatory bowel disease ... than hospitals with lower volumes of IBD patients, according ... College of Wisconsin in Milwaukee. ,The study ... for patients who undergo surgery for Crohn,s Disease, a ...
... SF-12v2 Health Survey Results are Used to Measure Physical ... and Mental Health Status of Program Participants, ... the,SilverSneakers(R) Fitness Program was created to encourage older adults ... the nation,s leading,fitness program aimed exclusively at older adults. ...
Cached Medicine News:Health News:Major Associations Band Together to Urge Congressional Action on Tobacco Legislation 2Health News:Hologic to Present at the Jefferies 2nd Annual Healthcare Conference 2Health News:FDA Panel Recommends Enbrel for Pediatric Patients 2Health News:FDA Panel Recommends Enbrel for Pediatric Patients 3Health News:Choice of hospital impacts outcomes for inflammatory bowel disease surgery 2Health News:Healthways Proves Effectiveness of Senior Fitness Program with QualityMetric Health Survey 2Health News:Healthways Proves Effectiveness of Senior Fitness Program with QualityMetric Health Survey 3
(Date:6/18/2013)... INDIANAPOLIS , June 18, 2013 The ... LLY ) has declared a dividend for ... on outstanding common stock. The dividend ... at the close of business on August 15, 2013. ... a growing portfolio of pharmaceutical products by applying the ...
(Date:6/18/2013)... , June 18, 2013 Remedy ... for healthcare and life sciences research, today announced ... Administration (GSA) IT Schedule 70 supply contract (GS-35F-367AA, ... to provide innovative IT solutions to government agencies ... with this contract, Remedy has placed its products ...
(Date:6/18/2013)... --  Polymer Technology Systems, Inc. (PTS) announced ... to integrate the CardioChek ® PA system ... systems across the country. The CardioChek PA lipid ... Hanson Medical Systems , offers immediate, on-site ... triglycerides, and glucose. (Logo: http://photos.prnewswire.com/prnh/20130618/DE33611LOGO ...
Breaking Medicine Technology:Remedy Informatics Awarded GSA Contract to Provide Innovative IT Solutions to Federal, State and Local Agencies 2Remedy Informatics Awarded GSA Contract to Provide Innovative IT Solutions to Federal, State and Local Agencies 3Remedy Informatics Awarded GSA Contract to Provide Innovative IT Solutions to Federal, State and Local Agencies 4Polymer Technology Systems, Inc. to Provide Point-of-Care Lipid Testing to Aegis Health Group's Hospital Clients 2Polymer Technology Systems, Inc. to Provide Point-of-Care Lipid Testing to Aegis Health Group's Hospital Clients 3
... Ortho Biotech Products, L.P., today announced that it has ... for the treatment of women with recurrent ovarian cancer ... and Drug Administration,s (FDA) recommendation that an additional Phase ... The NDA was submitted to the FDA in November, ...
... April 29, 2011 UBM Canon,s Medical Design ... Medical Design Excellence Awards (MDEA) Lifetime Achievement Award ... a long career have had a demonstrable impact on ... (Logo:   http://photos.prnewswire.com/prnh/20101214/LA16070LOGO ) Selected by ...
Cached Medicine Technology:Centocor Ortho Biotech Products, L.P. Voluntarily Withdraws NDA for Trabectedin 2UBM Canon and Medical Design Excellence Awards (MDEA) Announce Winner of Lifetime Achievement Award 2UBM Canon and Medical Design Excellence Awards (MDEA) Announce Winner of Lifetime Achievement Award 3
Blunt Weitlaner Retractor....
Weitlaner Beckmann retractor, sharp prongs, SS....
Baby Weitlaner retractor, blunt, 4"....
Scoville sharp curette, 10, straight, scoop size 4 x 10 mm....
Medicine Products: