Navigation Links
To combat deadly brain cancer, target the stem cells
Date:7/7/2011

Researchers have uncovered a new target that could stop the growth of glioblastoma, a deadly form of brain cancer. In the July 8th issue of the journal Cell, a Cell Press publication, a new study identifies an enzyme found in glioma stem cells that allows them to grow and seed tumors. Importantly, normal stem cells, including those in the brain, don't appear to share that same dependency.

"When thinking about therapeutics [targeting cancer stem cells], you have to be careful that you aren't interfering with normal stem cells," said Christine Eyler of the Cleveland Clinic. "Glioma stem cells are not derived from normal stem cells but they do share many features with them. The trick to therapy is to find pathways exhibited only by cancer stem cells."

The goal of Eyler's team, led by Cleveland Clinic scientist Jeremy Rich, was to identify just such a pathway in glioma stem cells, a particularly devastating form of brain cancer. Despite modern surgical and medical therapies, those diagnosed with a glioblastoma have a median survival of just over a year.

Previous work identifying glioma cells with stem-cell like behavior and demonstrating the propagation of gliomas in animals offered hope for the development of anti-glioma therapeutics. The challenge, however, has been finding pathways that differ between glioma and normal stem cells in spite of evidence that the glioma stem cells closely resemble embryonic and neural stem cells.

Earlier studies led the researchers to investigate the pathway that produces nitric oxide (NO), a molecule thought to support tumors' growth and resistance to treatment. Those experiments showed that glioma cells express varying levels of nitric oxide synthases, critical enzymes in that pathway.

"It's important to note that there are different forms of nitric oxide synthases," said Anita Hjelmeland, also at the Cleveland Clinic. "We focused on one that is well restricted to glioma stem ce
'/>"/>

Contact: Elisabeth Lyons
elyons@cell.com
617-386-2121
Cell Press
Source:Eurekalert

0

GOOD

Page: 1 2

Related medicine news :

1. Video games may help combat depression in older adults
2. National Hispanic Council on Aging Joins the Administration in Mission to Combat Medicare Fraud By Empowering Hispanics
3. SC Johnson and Bill & Melinda Gates Foundation Unite to Combat Malaria
4. Combat E-Cigarette in Demand by Civilians
5. The Net Impact Creates Website for St. Louis Event to Combat the Stigma of Mental Illness
6. HIV Drugs Might Combat Two Other Diseases
7. Children of combat-deployed parents show increased worries, even after parent returns
8. HealthMETRICS Partners, Inc. Article in AJMC Outlines Innovative Approach to Combat Rising Healthcare Costs
9. Holistic Management and Allan Savory Win the 2010 Buckminster Fuller Award for Turning Deserts into Thriving Grasslands and Combating Climate Change.
10. Novel Drug Combats Advanced Melanoma
11. US Army 2010 Combat Casualty Care Conference, Aug. 16-19, St. Pete Beach, Fla.
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/19/2013)... (PRWEB) June 19, 2013 Blueforce ... and sensor machine software, today announced it has ... its Decentralized Fusion Engine technology. The award ... the acquisition of key strategic partnerships. , ... wireless collaboration and machine-to-machine (M2M) software products that ...
(Date:6/19/2013)... A blow to the head; a swift jarring to ... to hours. It’s understandable, but what else may follow ... traumatic brain injury. According to mayoclinic.com , usual ... But many other symptoms may follow, sometimes not for ... include ongoing headaches, dizziness, feeling like you’re in a fog, ...
(Date:6/19/2013)... 19, 2013 Walkingspree, a specialized wellness ... the launch of its new Facebook App. This is ... inspire participants to reach their program fitness goals. Consistent ... Walkingspree clients are given more tools to customize their ... , Corporate clients may choose whether or not they ...
(Date:6/19/2013)... Weight gain and obesity have been ... including heart disease, kidney failure and high blood pressure. ... and unnecessary fat, have many people searching for fast ... diets to not only allow patients to succeed ... aim to reduce the risk for many weight-related health ...
(Date:6/19/2013)... June 19, 2013 The reason for the ... because users can place a 4x8 flood tray inside the ... to work around. In addition, Gorilla Grow Tents are ... are the tallest, thickest and strongest grow tents on the ... grow tent standards. , Gorilla Grow Tents are ...
Breaking Medicine News(10 mins):Health News:Blueforce Awarded Patent for Decentralized Sensor Fusion 2Health News:Concussions Can Lead to Much More Than a Headache, According to MMTR Health Inc. Founder, Terry Moore, Neuromuscular and Cardiovascular Physiologist 2Health News:Walkingspree’s New Facebook Connectivity Boosts Accountability and Engagement 2Health News:hCGTreatments / Diet Doc hCG Diets & Weight Loss Plans Offers New Fast Weight Loss Programs for Patients Suffering with Health Care Concerns 2Health News:hCGTreatments / Diet Doc hCG Diets & Weight Loss Plans Offers New Fast Weight Loss Programs for Patients Suffering with Health Care Concerns 3Health News:Stealth Grow Tent Brand’s Popularity Rises 2
... disused proteins are eliminated by a cellular shredder called ... to dispose with Ubiquitin (Ub) in order to avoid ... in the ubiquitin-proteasome system can be fatal for the ... disorders but also developmental defects are the consequences. The ...
... the first scientific review of a dozen patients who have ... gene therapy technique is safe and may be effective at ... patients, half of whom live on Long Island, are in ... to medicines when they signed on for the experimental therapy. ...
... on June 26, after spending 23 days in the slammer. ... Angeles County Sheriff's Department's Inmate Reception Center. ,The exact ... ,Although her sentence was for 45 days, authorities have said ... good behaviour. ,"There was some confusion as to whether ...
... new details about how proteins used to destroy bacteria ... ,Gunnar K. Gouras, associate professor of neurology and ... York, and colleagues provide new insights into how these ... disease and raise hopes for a vaccine against the ...
... a credible scientific method for testing and measuring ... on XanGo Juice , indicate usage of the ... to high xanthone absorption. ,XanGo, LLC, ... leading scientific exploration of the whole mangosteen fruit ...
... is making all possible arrangements to look good on her yet ... thing that the socialite will do after being released on June ... complained to the press while in jail that she's not permitted ... going dry. ,So, the heiress has booked a facial ...
Cached Medicine News:Health News:Protein Targets for Carcinogenesis 2Health News:Gene Therapy for Parkinsons Disease 2Health News:Researchers Link Bacteria Destroying Proteins to Alzheimer's Treatment 2Health News:Researchers Link Bacteria Destroying Proteins to Alzheimer's Treatment 3Health News:New Technique to Measure Xanthone in Mangosteen 2Health News:New Technique to Measure Xanthone in Mangosteen 3
(Date:6/18/2013)... , June 18, 2013 New-generation electronic ... highly portable and lightweight. Simultaneously, circuitry is increasing ... processing speed to which it performs at. Connecting ... electronics and military equipment, such as cameras or ... micro-circular and nano-circular connectors include custom cable designs ...
(Date:6/18/2013)... DENVER , June 18, 2013  Healthgrades, ... evaluate, compare and connect with physicians and hospitals, ... 2013: "Lean in" When Making Healthcare Decisions to ... the best performing hospitals for maternity care, gynecologic ... the treatment of women across 15 of the ...
(Date:6/18/2013)... And EMERYVILLE, Calif. ... Inc. presented final results today from a Phase ... release) capsules demonstrating a statistically significant improvement in ... baseline at week 8 versus placebo in the ... investigational extended-release formulation of amantadine intended for once-nightly ...
Breaking Medicine Technology:Omnetics Circular Connectors Offer Both Micro and Nano Interconnects for Highly Portable Electronic Systems, Meeting the Needs of Designers Looking for Size Reduction Options and Cable Flexibility 2Healthgrades Recognizes Top Hospitals in Treatment of Maternity Care, Gynecologic Surgery and Women's Health 2Healthgrades Recognizes Top Hospitals in Treatment of Maternity Care, Gynecologic Surgery and Women's Health 3Healthgrades Recognizes Top Hospitals in Treatment of Maternity Care, Gynecologic Surgery and Women's Health 4Adamas Pharmaceuticals Presents Positive Phase 2/3 Results For ADS-5102 For The Treatment Of Levodopa-Induced Dyskinesia (LID) In Parkinson's Disease 2Adamas Pharmaceuticals Presents Positive Phase 2/3 Results For ADS-5102 For The Treatment Of Levodopa-Induced Dyskinesia (LID) In Parkinson's Disease 3Adamas Pharmaceuticals Presents Positive Phase 2/3 Results For ADS-5102 For The Treatment Of Levodopa-Induced Dyskinesia (LID) In Parkinson's Disease 4Adamas Pharmaceuticals Presents Positive Phase 2/3 Results For ADS-5102 For The Treatment Of Levodopa-Induced Dyskinesia (LID) In Parkinson's Disease 5Adamas Pharmaceuticals Presents Positive Phase 2/3 Results For ADS-5102 For The Treatment Of Levodopa-Induced Dyskinesia (LID) In Parkinson's Disease 6
... 2011 Columbia Laboratories, Inc. (Nasdaq: CBRX ) ... announced that the U.S. Food and Drug Administration (FDA) has ... ® (progesterone gel) for the reduction of risk of ... the mid-trimester of pregnancy. The acceptance of the NDA for ...
... (NASDAQ: OMER ) today reported that it has ... P2Y8 and OPN4. P2Y8 (also known as P2RY8) is associated ... white blood cells. ALL is the most common type of ... regulation of circadian rhythms, and could provide a target for ...
Cached Medicine Technology:Columbia Laboratories' NDA for PROCHIEVE® Vaginal Progesterone Gel Accepted for Filing by FDA 2Columbia Laboratories' NDA for PROCHIEVE® Vaginal Progesterone Gel Accepted for Filing by FDA 3Columbia Laboratories' NDA for PROCHIEVE® Vaginal Progesterone Gel Accepted for Filing by FDA 4Omeros Unlocks Orphan GPCRs Linked to Leukemia and Sleep Disorders 2Omeros Unlocks Orphan GPCRs Linked to Leukemia and Sleep Disorders 3Omeros Unlocks Orphan GPCRs Linked to Leukemia and Sleep Disorders 4
Blunt Weitlaner Retractor....
Weitlaner Beckmann retractor, sharp prongs, SS....
Baby Weitlaner retractor, blunt, 4"....
Scoville sharp curette, 10, straight, scoop size 4 x 10 mm....
Medicine Products: