Navigation Links
Telomeres: 2 genes linked to why they stretch in cancer cells
Date:6/30/2011

at Johns Hopkins.

Following a hunch, Meeker and his colleagues took a closer look at the two genes and their specific role in telomere lengthening. With tissue samples from 41 patients with pancreatic neuroendocrine tumors collected during the genome mapping project, the scientists found characteristic signatures of alternative telomere lengthening in 25 of them. Fluorescent dyes targeted specifically to telomeres showed "huge aggregates of telomere DNA" in the 25 samples, with each fluorescent spot holding about 100 times more telomere DNA than normal cells, according to Meeker.

Nineteen of the 25 samples that glowed positive for alternative telomere lengthening had either ATRX or DAXX mutations. Six of those 25 samples did not contain ATRX or DAXX mutations, but the tumor cells showed no expression of these two genes. The remaining 16 samples with no alternative lengthening lacked mutations and had adequate ATRX and DAXX expression.

"We saw a 100 percent correlation between abnormalities in ATRX and DAXX and alternative lengthening of telomeres," says Meeker.

Among 439 other samples of tumors tested by Meeker, Papadopoulos and colleagues, ATRX mutations were found in several brain cancer types, including pediatric and adult glioblastoma samples provided by Hai Yan, M.D., Ph.D., and Darell Bigner, M.D., Ph.D., of Duke University.

Meeker and colleagues tested the telomeres status in glioblastoma samples with tissue available for the assay. All eight glioblastoma tissue samples with ATRX mutations showed the characteristic bright glow of their telomeres, indicative of alternative lengthening, and lack of ATRX expression.

Although the Johns Hopkins team does not yet have an explanation for how the genes do their lengthening work in cancer, Meeker speculates that the mutations alter the way that telomere DNA is packaged, exposing those areas to instability.

Papadopoulos' genome mapping studies showed that
'/>"/>

Contact: Vanessa Wasta
wasta@jhmi.edu
410-955-1287
Johns Hopkins Medical Institutions
Source:Eurekalert  

0

GOOD

Page: 1 2 3

Related medicine news :

1. Genes Play Role in Prognosis With Non-Small Cell Lung Cancers
2. Researchers Who Discovered First Genes for Stuttering will Present Findings to the National Stuttering Association
3. Genes, environment, or chance?
4. UCLA study reveals how genes interact with their environment to cause disease
5. Long-Distance Runners May Have Endurance in Their Genes
6. Genes Behind Tooth Development Discovered
7. Smoking significantly increases risk of aneurysm in people with certain genes
8. Increasing neurogenesis might prevent drug addiction and relapse
9. Genetic Disease Foundation Encourages Americans to Know Their Genes at KnowYourGenes.org in Observance of World Rare Disease Day
10. Cluster of Genes Tied to Alcoholism
11. Cardiogenesis Reports Fourth Quarter and Full-Year 2009 Results
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Telomeres: 2 genes linked to why they stretch in cancer cells
(Date:5/24/2013)... ShopPharmacyCounter.com PhenObestin 37.5 Summer Sale Now ... price reductions on their popular PhenObestin 37.5 non-prescription diet ... to lose weight as effortlessly as possible has reduced ... than 50%. , Bottles have been reduced from $149 ... orders will receive free shipping. , Made from ...
(Date:5/24/2013)... (PRWEB) May 24, 2013 Before you start the ... of coffee with Kathie Lee Gifford and Hoda Kotb on the ... will show cool tech ideas to Kathie Lee and Hoda, including ... honors our brave men and women in the military who made ... for the BBQ, spend time with friends and family and enjoy ...
(Date:5/24/2013)... Patients hospitalized for heart failure appear to have better ... in the morning, a new study finds. Death ... failure patients admitted in January, on Fridays and overnight, ... their findings Saturday in Portugal at the annual meeting ... of Cardiology. "The fact that patients admitted ...
(Date:5/24/2013)... May 24, 2013 With Memorial Day Weekend ... Amica Insurance is offering tips to help prevent grill ... Fire Protection Association (NFPA) reports that gas grills led ... 2010. Charcoal or other solid-fueled grills, meanwhile, caused approximately 1,200 ... a result, Amica Insurance is sharing the following tips from ...
(Date:5/24/2013)... JOLLA, Calif.) (PRWEB) May 24, 2013 ... to House Appropriators and the California congressional delegation, ... to restore sequestered industry user fees paid to ... and to ensure that future across-the-board cuts will ... part of the FY14 Agriculture, Rural Development and ...
Breaking Medicine News(10 mins):Health News:ShopPharmacyCounter.com PhenObestin 37.5 Summer Sale Now On 2Health News:LawnBott® Visits the Today Show with Kathie Lee and Hoda 2Health News:Monday Best Time for Hospitalization With Heart Failure, Study Says 2Health News:Don’t Get Burned: Five Grilling Tips from Amica Insurance 2Health News:California Biomedical Industry Leaders Urge Congress to Take Action on FDA User Fees for FY2014 2Health News:California Biomedical Industry Leaders Urge Congress to Take Action on FDA User Fees for FY2014 3
... child,s weight can significantly lower the radiation dose associated ... a study published in the May issue of the ... CT scanning combines special X-ray equipment with sophisticated computers ... of the body. The study, performed at ...
... ... , ... (Vocus) -- ShelterBox Response Team Member and graduate student, Beverly Hill, describes the flight ... fallen buildings, and people lining the streets in their makeshift dwellings. ShelterBox is ...
... ... Dr. Mauskop’s Migralex™ on Sex-Related and Exertional Headaches , ... New York, NY (Vocus) April 21, 2010 -- ... and women, sex can actually trigger a headache. In fact, sex-related headaches bear relation ...
... half to two-thirds of women of childbearing age fit ... A new study says federal guidelines on obesity should ... of "obese." , U.S. guidelines determine who is obese ... person,s height and weight are proportional. The researchers found ...
... And they took 50 percent fewer prescription drugs for ... Patients who,ve lost weight after bariatric surgery breathe ... a new study finds. , Researchers reviewed the medical ... after they had bariatric surgery at Henry Ford Hospital ...
... (April 21, 2010) The first formal U.S. government ... Americans, were published in 2008. Now, those guidelines have ... in the American Journal of Lifestyle Medicine , ... Americans are comprised of recommendations regarding the types and ...
Cached Medicine News:Health News:With Rainy Season Looming, Florida Woman Rushes to Aid of Haitians 2Health News:With Rainy Season Looming, Florida Woman Rushes to Aid of Haitians 3Health News:Love Making And Exercise Can Trigger Headache Pain? 2Health News:Love Making And Exercise Can Trigger Headache Pain? 3Health News:More U.S. Women May Be Obese Than Thought 2Health News:Physical Activity Guidelines for Americans interpreted for practical use 2
(Date:5/24/2013)...  An international roster of experts on malignant pleural ... Santa Monica, Calif. , to discuss their ... a rare form of cancer that results from exposure ... of the chest. Hosted by UCLA and ... Annual International Symposium on Lung-Sparing Therapies for Malignant Pleural ...
(Date:5/24/2013)... NEW YORK , May 24, 2013 In ... Takeover Rules and Rule 14e-1 of the United States Exchange ... levels its original offer for Elan Corporation (NYSE: ELN). ... Acquisition Limited ("Royalty Pharma") made an offer for the entire ... Elan Corporation, plc ("Elan") (the "Original Offer").  ...
(Date:5/23/2013)... 24, 2013 3SBio Inc. (NASDAQ: ... leading China -based biotechnology company ... products, announced today that, at an extraordinary general ... voted in favor of the proposal to authorize ... of merger dated February 8, 2013, among Decade ...
Breaking Medicine Technology:International Mesothelioma Experts Present Promising New Research Findings at the 3rd Annual International Symposium on Lung-Sparing Therapies for Malignant Pleural Mesothelioma 2International Mesothelioma Experts Present Promising New Research Findings at the 3rd Annual International Symposium on Lung-Sparing Therapies for Malignant Pleural Mesothelioma 3Royalty Pharma Discloses Acceptance Levels of Original Offer for Elan Pursuant to Irish and United States Regulatory Requirements 2Royalty Pharma Discloses Acceptance Levels of Original Offer for Elan Pursuant to Irish and United States Regulatory Requirements 3Royalty Pharma Discloses Acceptance Levels of Original Offer for Elan Pursuant to Irish and United States Regulatory Requirements 4Royalty Pharma Discloses Acceptance Levels of Original Offer for Elan Pursuant to Irish and United States Regulatory Requirements 5Royalty Pharma Discloses Acceptance Levels of Original Offer for Elan Pursuant to Irish and United States Regulatory Requirements 6Royalty Pharma Discloses Acceptance Levels of Original Offer for Elan Pursuant to Irish and United States Regulatory Requirements 7Royalty Pharma Discloses Acceptance Levels of Original Offer for Elan Pursuant to Irish and United States Regulatory Requirements 8Royalty Pharma Discloses Acceptance Levels of Original Offer for Elan Pursuant to Irish and United States Regulatory Requirements 93SBio Inc. Announces Shareholders' Approval of the Amended Merger Agreement 23SBio Inc. Announces Shareholders' Approval of the Amended Merger Agreement 3
... Presented at 2007 APA Meeting -, COLLEGEVILLE, ... four new studies examining safety and efficacy ... studied as a potential treatment for adults,with ... at the,2007 American Psychiatric Association annual meeting ...
... Childhood Condition, WASHINGTON, May 22, 2007 /PRNewswire-FirstCall/ ... pediatric patients,with gastroesophageal reflux disease (GERD) during ... Disease Week meeting held at the,Washington Convention ... support AstraZeneca's,commitment to research in the area ...
Cached Medicine Technology:New Study Results Provide Additional Data about Short- and,Long-Term Use of Desvenlafaxine Succinate in the Treatment of,Adults with Major Depressive Disorder 2New Study Results Provide Additional Data about Short- and,Long-Term Use of Desvenlafaxine Succinate in the Treatment of,Adults with Major Depressive Disorder 3New Study Results Provide Additional Data about Short- and,Long-Term Use of Desvenlafaxine Succinate in the Treatment of,Adults with Major Depressive Disorder 4New Study Results Provide Additional Data about Short- and,Long-Term Use of Desvenlafaxine Succinate in the Treatment of,Adults with Major Depressive Disorder 5New Study Results Provide Additional Data about Short- and,Long-Term Use of Desvenlafaxine Succinate in the Treatment of,Adults with Major Depressive Disorder 6New Study Results Provide Additional Data about Short- and,Long-Term Use of Desvenlafaxine Succinate in the Treatment of,Adults with Major Depressive Disorder 7New Study Results Provide Additional Data about Short- and,Long-Term Use of Desvenlafaxine Succinate in the Treatment of,Adults with Major Depressive Disorder 8New Studies Evaluating NexiumIn Pediatric GERD To Be Presented At,Annual Digestive Disease Week Meeting 2New Studies Evaluating NexiumIn Pediatric GERD To Be Presented At,Annual Digestive Disease Week Meeting 3New Studies Evaluating NexiumIn Pediatric GERD To Be Presented At,Annual Digestive Disease Week Meeting 4New Studies Evaluating NexiumIn Pediatric GERD To Be Presented At,Annual Digestive Disease Week Meeting 5
... order tips. Each box contains 10,000 tips ... in easy-to-open, re-sealable Bulk Packs of 200 ... with a tamper-proof strip which can easily ... Diamond Tips. Bulk Packs are closed using ...
Capillary section fits into a 0.3-mm well for accurate loading of sequencing gels - Ideal for use with CastAway System...
This extended 10 ul combats contamination by keeping your pipettor out of 1.5 ul and 2.0 ul tubes. Utilizes MicroPoint design and 2 ul reference mark....
... powerful motor with a lightweight, comfortable design. ... three positions for maximum comfort and convenience.mum ... button on the top of the filler ... wide-angle position is ideal for restricted spaces ...
Medicine Products: