Navigation Links
Study reveals how anesthetic isoflurane induces Alzheimer's-like changes in mammalian brains
Date:3/1/2012

l damage.

In a series of experiments, the investigators found that the application of isoflurane to cultured cells and mouse neurons increased the permeability of mitochondrial membranes; interfered with the balance of ions on either side of the mitochondrial membrane; reduced levels of ATP, the enzyme produced by mitochondria that powers most cellular processes; and increased levels of the cell-death enzyme caspase. The results also suggested that the first step toward isoflurane-induced cell death was increased generation of reactive oxygen species unstable oxygen-containing molecules that can damage cellular components. The performance of mice on a standard behavioral test of learning and memory declined significantly two to seven days after administration of isoflurane, compared with the results of a control group. None of the cellular or behavioral effects of isoflurane were seen when the administered agent was desflurane.

In another study by members of the same research team appearing in the February issue of Anesthesia and Analgesia and published online in November about a quarter of surgical patients receiving isoflurane showed some level of cognitive dysfunction a week after surgery, while patients receiving desflurane or spinal anesthesia had no decline in cognitive performance. That study, conducted in collaboration with investigators from Beijing Friendship Hospital in China, enrolled only 45 patients 15 in each treatment group so its results need to be confirmed in significantly larger groups.

"Approximately 8.5 million Alzheimer's disease patients worldwide will need anesthesia and surgical care every year," notes Zhongcong Xie, MD, PhD, corresponding author of both studies and director of the Geriatric Anesthesia Research Unit in the MGH Department of Anesthesia, Critical Care and Pain Medicine. "Developing guidelines for safer anesthesia care for these patients will require collaboration between specialists in
'/>"/>

Contact: Sue McGreevey
smcgreevey@partners.org
617-724-2764
Massachusetts General Hospital
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Mouse Study Shows How Pot Clouds Memory
2. New study reveals more people surviving leukaemia and pancreatic cancer in Northern Ireland
3. Study: Sleep gets better with age, not worse
4. Fitness programs for minority adults lack cultural relevance, MU study finds
5. Preschool Kids Best Prepared for Kindergarten: Study
6. Ragon Institute study finds HIV-specific CD4 cells that control viral levels
7. Study finds new genes that cause Baraitser-Winter syndrome, a brain malformation
8. Older Prostate Cancer Patients Might Be Overtreated: Study
9. Study: Over 100,000 Californians likely to miss out on health care due to language barriers
10. Women & Infants studying therapies to relieve urinary urge incontinence
11. Parents Often Right to Bring Kids With Fever to the ER: Study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/20/2014)... September 20, 2014 Ticket Down ... tickets . This popular ticket exchange is offering their ... , The 2015 schedule of tours is beginning to fill ... announced their plans to hit the road, including 21-year-old pop ... announced the “Honeymoon Tour,” which will take her to 25 ...
(Date:9/20/2014)... 2014 The print component of ... of the Calgary Herald, with a circulation of ... 270,000. The digital component is distributed nationally through ... network of top news sites and partner outlets. ... visit http://www.worklifebalanceinfo.ca . , The publication features ...
(Date:9/20/2014)... festival season is coming soon. The high-end fashion designer BellasDress ... dresses . A lot of sophisticated women like its new ... promotion for its high quality clothes. Now, each of its ... to 71 percent off. , The company’s cocktail dress ... in many fashionable colors. Mary, the company’s sales manager, believes ...
(Date:9/20/2014)... 2014 iFitDress.com, the popular online supplier ... has recently unveiled its new collection of cocktail gowns. ... special offer on these new outfits; it intends to ... customers can now buy cheap cocktail dresses ... representative says, “We have extensive experience in the industry ...
(Date:9/20/2014)... 20, 2014 "As a nurse, patients always ... said an inventor from Tamaqua, Pa. "The reason that they ... backs of their chairs. My invention enables them to check ... Oxygen Sensor to make it easier to monitor the contents ... knows when the tank is low. It allows changeovers to ...
Breaking Medicine News(10 mins):Health News:Ariana Grande Tickets in Phoenix, Los Angeles, Anaheim, San Jose, Seattle, and Vancouver Go on Sale Today 2Health News:Ariana Grande Tickets in Phoenix, Los Angeles, Anaheim, San Jose, Seattle, and Vancouver Go on Sale Today 3Health News:Getting ‘Wellthy’: Mediaplanet’s “Work-Life Wellness” campaign puts stock in the personal and economic gains of healthy, vital workplace environments for Canadians 2Health News:High-end Fashion Designer BellasDress Offers Luxurious Cocktail Dresses For Sophisticated Women 2Health News:Fashionable Cocktail Dresses Unveiled Online at iFitDress.com 2
... , , , ... leading provider of advanced clinical documentation software, workflow tools, consulting ... as Corporate Vice President of Marketing and Communications. Reporting ... with designing and implementing new marketing initiatives that blend the ...
... NEW ORLEANS, July 29 Smoothie King, the 1973 originator ... leading the way to making healthy alternatives and high-quality meal replacements available ... Consumers in Tokyo will be the first in Japan to enjoy the ... open in 2010. Japan makes sense as the latest Smoothie King market, ...
... HAIKOU CITY, China, July 29 /PRNewswire-Asia-FirstCall/ -- China ... develops,manufactures, and markets specialty pharmaceutical products in China, today,announced ... results on,Wednesday, August 12, 2009, before the market opens. ... a conference call at 8:00 am ET on August ...
... , SOUTH SAN FRANCISCO, Calif., July 29 ... biopharmaceutical company focused on innovative oncology therapies, today announced that ... to provide a corporate overview, including a discussion about the ... at two upcoming investor conferences: , , ...
... chemo, expert says , WEDNESDAY, July 29 (HealthDay News) ... tumors show promise, U.S. researchers report. , The nanoparticles ... fatty molecules that can be designed to carry a ... to control how long they remain in the bloodstream. ...
... , , DARIEN, Conn., July 29 ... Switch , a sparkling 100% juice, is expanding its availability into ... The Switch has added key retailers Tops, D,Agostinos, ... And the list of eager retailers keeps growing with Wegmans, Price ...
Cached Medicine News:Health News:Precyse Solutions Taps Former Siemens Executive to Lead New Marketing Organization 2Health News:Smoothie King Expansion Signals International Trend Toward Healthy Living 2Health News:Smoothie King Expansion Signals International Trend Toward Healthy Living 3Health News:China Pharma Holdings, Inc. to Report Second Quarter 2009 Financial Results on August 12, 2009 2Health News:Poniard Pharmaceuticals to Present at Two Upcoming Investor Conferences in August 2Health News:Scientists Test New Way to Get Drugs to Cancer Cells 2Health News:People Across the Country are Making The Switch! 2
(Date:9/20/2014)... The issue: Mylan Pharmaceuticals ULC Canada, in consultation with Health ... 0.4 mg/metered dose due to the product missing the "dip ... A missing "dip tube" could pose a potential problem ... may lead patients to believe they are receiving the nitroglycerin, ... receiving nitroglycerin could place them at risk for either a ...
(Date:9/19/2014)... , Sept. 19, 2014 Medical science ... relationships with key opinion leaders (KOLs) who can ... Despite the critical nature of the MSL function, ... including altering the landscape for creating and maintaining ... to research, the oversight responsibility for the MSL ...
(Date:9/19/2014)... , Sept. 19, 2014 Harwood Feffer LLP ... board of directors of PDL BioPharma, Inc. ("PDL" or ... the board has breached its fiduciary duties to shareholders ... September 16, 2014, the Company disclosed: "On September 11, ... accounting firm, Ernst & Young LLP ("EY"), that it ...
Breaking Medicine Technology:Advisory - Mylan Pharmaceuticals recalling nitroglycerin spray due to defective pump 2Role of Medical Science Liaisons Shifting in Healthcare Industry 2Harwood Feffer LLP Announces Investigation of PDL BioPharma, Inc. 2
... 2011 ,   EP ... of the Year Award at the European Mediscience,Awards, sponsored ... award, which honours clear and concise commentary in the,pharma ... research houses or specialist websites dedicated to,providing sharp, perceptive ...
... 24, 2011 New Phase 2 clinical trial data ... of Medicine show that patients with moderate to ... bardoxolone methyl for 52 weeks experienced a sustained improvement ... by estimated glomerular filtration rate (eGFR). The data were ...
Cached Medicine Technology:EP Vantage Wins Commentator of the Year Award at European Mediscience Awards 2011 2EP Vantage Wins Commentator of the Year Award at European Mediscience Awards 2011 3New Phase 2 Data Published in New England Journal of Medicine Show Bardoxolone Methyl Sustained Improvement in Measure of Kidney Function (eGFR) Over 52 Weeks in Patients With Moderate to Severe Chronic Kidney Disease and Type 2 Diabetes 2New Phase 2 Data Published in New England Journal of Medicine Show Bardoxolone Methyl Sustained Improvement in Measure of Kidney Function (eGFR) Over 52 Weeks in Patients With Moderate to Severe Chronic Kidney Disease and Type 2 Diabetes 3New Phase 2 Data Published in New England Journal of Medicine Show Bardoxolone Methyl Sustained Improvement in Measure of Kidney Function (eGFR) Over 52 Weeks in Patients With Moderate to Severe Chronic Kidney Disease and Type 2 Diabetes 4
Drugs of Abuse (DoA) Array is used for in-vitro diagnostic tests for the qualitative determination of the parent molecule and metabolites of drugs in human urine....
Stat Detection of Soluble Fibrin Monomer Complexes by the Hemagglutination Technique, 32 tests....
Batch Detection of Soluble Fibrin Monomer Complexes by the Hemagglutination Technique, 40 tests....
For use with catalog #0454....
Medicine Products: