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Stem Cell Transplant May Help Aggressive MS: Study
Date:3/21/2011

sitive brain changes on an MRI.

Now, after 15 years, the authors report that overall 25 percent of the 35 initial patients are stabilized. The success rate was better -- 44 percent -- for those with active brain lesions, signaling aggressive disease, they found.

Many had a lessening of their disability, and fewer and smaller lesions in the brain.

But two participants, or 6 percent, died of complications from the transplant.

Research on this aggressive therapy is continuing, say the authors, from Aristotle University of Thessaloniki Medical School in Greece.

But more information might be hard to come by because the treatment's high mortality rate makes it difficult to recruit patients.

Still, they said, HSCT might be a "salvage" therapy for hard-to-treat MS.

"It's a possible treatment strategy, but it remains to be seen how much of a treatment option it is," said Dr. Mark Keegan, associate professor of neurology at the Mayo Clinic in Rochester, Minn.

"We do need ways to treat people with aggressive MS," he added.

More information

Visit the National Multiple Sclerosis Society for more on this disease.

SOURCES: Aaron Miller, M.D., chief medical officer, National Multiple Sclerosis Society, and associate professor of neurology and director, Corinne Goldsmith Dickinson Center for Multiple Sclerosis, Mount Sinai School of Medicine, New York City; Mark Keegan, M.D., associate professor of neurology, Mayo Clinic, Rochester, Minn.; March 22, 2011 Neurology


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