Navigation Links
Slowing the allergic march
Date:8/14/2011

PHILADELPHIA - A pandemic of ailments called the "allergic march" -- the gradual acquisition of overlapping allergic diseases that commonly begins in early childhood -- has frustrated both parents and physicians. For the last three decades, an explosion of eczema, food allergies, hay fever, and asthma have afflicted children in the United States, the European Union, and many other countries.

What causes the march and how to derail it has remained elusive. Now, in this week's Nature, David Artis, PhD, an associate professor of Microbiology at the Perelman School of Medicine at the University of Pennsylvania, and a team of collaborating international scientists, identified that expression of the protein TSLP may influence susceptibility to multiple allergic diseases by regulating the maturation of basophils, an uncommon type of white blood cell. Specifically, TSLP elicits the maturation of a population of distinct basophils that promotes allergic inflammation.

"A fundamental question regarding the allergic march is if a child has eczema, for example, which is associated with TSLP production in skin cells, why would some of those children subsequently be more susceptible to other allergic diseases at different sites of the body such as the gut or the lung?" asks Artis. "Although we have known that TSLP is associated with allergic diseases for many years, how this biological messenger might influence multiple allergic diseases has been a puzzle."

The origins of the present study lie in previous reports that showed that different versions of the gene encoding TSLP, an inflammation-producing cytokine, are associated with increased susceptibility to multiple allergic disorders, and that exaggerated TSLP production is associated with asthma, eczema, and food allergies in children. Together, these studies indicate that TSLP could be a critical regulator of multiple cytokine-associated allergic inflammatory diseases.

In thi
'/>"/>

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
Source:Eurekalert  

0

GOOD

Page: 1 2

Related medicine news :

1. Slowing the spread of drug-resistant diseases is goal of new research area
2. Smoking, Obesity Slowing U.S. Life Expectancy Gains: Report
3. Pharmaceutical conservation key to slowing rise of antibiotic-resistant infections
4. Study: Hypoallergenic dogs not less allergic than other dogs
5. Kids Eczema, Hay Fever Linked to Allergic Asthma Later
6. Childhood eczema and hay fever leads to adult allergic asthma
7. Protein associated with allergic response causes airway changes in asthma patients
8. Vaccinated children not at higher risk of infections or allergic diseases
9. Vitamin D may treat and prevent allergic reaction to mold in cystic fibrosis patients
10. Those with allergic asthma face double trouble during flu season, UT Southwestern findings suggest
11. Nuvo Research enrolls first patient in Phase 2 WF10 allergic rhinitis trial
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Slowing the allergic march
(Date:5/23/2013)... (PRWEB) May 23, 2013 Visage Imaging ... (ASX: PME), announced today that they have released ... the Apple App Store*. When used in tandem with ... Ease provides authorized healthcare providers simple mobile access to ... devices. , In addition to numerous enhancements and performance ...
(Date:5/23/2013)... (PRWEB) May 23, 2013 Registered Dietitian ... published an article today on Tatalou.com offering helpful tips ... , The article, titled “ How to Stay Healthy ... to carry hand sanitizer, when it’s safe to drink ... for seafood, the importance of staying hydrated and how ...
(Date:5/23/2013)... Memorial Day is Monday, May 27, a day that marks ... the nation, people will have picnics, visit loved ones, and ... to those who have experienced the loss of a loved ... Day this year, the U.S. is still involved in conflicts ... men and women remind all Americans that life is precious. ...
(Date:5/23/2013)... York, NY (PRWEB) May 23, 2013 ... New York Supreme Court (reference number 110504/2009) by Lori ... a verdict awarding Ms. Mandel $8.6 million. Ms. Mandel ... whose alleged misdiagnosis led to further complications that affected ... perform her work. , The plaintiff alleged that her ...
(Date:5/23/2013)... May 23 2013 - New techniques in imaging ... from McGill University,s Montreal Neurological Institute, and his ... from epilepsy. The combination of electroencephalogram (EEG) ... more precise localization of the areas generating epileptic ... optimal ways of intervention, if appropriate. These ...
Breaking Medicine News(10 mins):Health News:Mobile Imaging Access Leaps Ahead with Visage Ease 2Health News:Mobile Imaging Access Leaps Ahead with Visage Ease 3Health News:How to Stay Healthy While Traveling 2Health News:Memorial Day: Make it a Time of Remembrance and Support 2Health News:Memorial Day: Make it a Time of Remembrance and Support 3Health News:New York Law Journal Releases Top Medical Malpractice Case for 2012: NY Supreme Court Awards $8.6 Million to Plaintiff after Doctor's Misdiagnosis Led to Personal Injury 2Health News:New York Law Journal Releases Top Medical Malpractice Case for 2012: NY Supreme Court Awards $8.6 Million to Plaintiff after Doctor's Misdiagnosis Led to Personal Injury 3Health News:New imaging techniques used to help patients suffering from epilepsy 2
... , TUESDAY, May 10 (HealthDay News) -- Breast-fed ... 5 than are those who were given formula, a new ... data on 10,037 mother-child pairs taking part in a study ... to 2001, including 9,525 carried full-term and 512 children who ...
... A landmark study by scientists at Wayne State University published ... General Psychiatry , the most prestigious journal in the field, ... depressive disorder (MDD) from not only normal children, but also ... is a common, debilitating disease prevalent in childhood and adolescence. ...
... The winner of the Cephalalgia Award Lecture, which ... the journal Cephalalgia between January 1, 2010 and ... is A new trigemino-nociceptive stimulation model for event-related fMRI by ... May Cephalalgia 2010; 30: 475�. The authors ...
... by the government to enable specially trained nurses and ... adopted, according to a new report. Health service ... widespread acceptance of the new powers among patients and ... type of medical conditions being treated. The Department ...
... HealthDay Reporter , MONDAY, May 9 (HealthDay News) -- ... that long-term use of popular heartburn drugs such as ... risk of fractures. Scientists conducting a meta-analysis of ... proton pump inhibitors (PPIs), which reduce stomach acid production, ...
... at Schepens Eye Research Institute shows that a bioptic telescope ... magnify traffic signs and lights may not prevent the wider ... study results, which will be published in the May 2011 ... more realistic viewing conditions than in earlier studies--the second eye ...
Cached Medicine News:Health News:Breast-Feeding May Help Quell Behavior Problems 2Health News:Wayne State researchers find new way to examine major depressive disorder in children 2Health News:Cephalalgia Award Lecture winner announced 2Health News:Wide-reaching report finds strong support for nurse and pharmacist prescribing 2Health News:Popular Heartburn Meds May Boost Fracture Risk 2Health News:Popular Heartburn Meds May Boost Fracture Risk 3Health News:Single bioptic telescope for low vision driving may not obscure road view of second eye 2Health News:Single bioptic telescope for low vision driving may not obscure road view of second eye 3
(Date:5/23/2013)... CARLSBAD, Calif. , May 23, 2013 Isis ... antisense therapeutics, today announced that management will present a company ... Health Care Conference on Thursday, May 30, 2013 at 8:40 ... A live audio webcast of the presentation will be ... Web site, www.isispharm.com .  A replay will be available ...
(Date:5/23/2013)... , May 23, 2013  Echo Pharma Acquisition ... to waive down the Acceptance Threshold from 90 percent ... one Elan Share in accordance with the terms of ... conditions summarized below. Under the terms of ... Elan (NYSE: ELN ) for $12.50 per ...
(Date:5/23/2013)... PARIS , May 23, 2013  Volcano Corporation ... manufacturer of precision guided therapy tools designed to enhance ... disease, today announced preliminary results from the ADVISE ( ... S tenosis E valuation) II trial during the ... 2013. These prospective results confirm prior retrospective publications, and ...
Breaking Medicine Technology:Isis Pharmaceuticals to Present at the Deutsche Bank 38th Annual dbAccess Health Care Conference 2Royalty Pharma Reduces Acceptance Condition to 50% Plus One Share 2Royalty Pharma Reduces Acceptance Condition to 50% Plus One Share 3Royalty Pharma Reduces Acceptance Condition to 50% Plus One Share 4Royalty Pharma Reduces Acceptance Condition to 50% Plus One Share 5Royalty Pharma Reduces Acceptance Condition to 50% Plus One Share 6Royalty Pharma Reduces Acceptance Condition to 50% Plus One Share 7Royalty Pharma Reduces Acceptance Condition to 50% Plus One Share 8Royalty Pharma Reduces Acceptance Condition to 50% Plus One Share 9Royalty Pharma Reduces Acceptance Condition to 50% Plus One Share 10Volcano Announces Preliminary Results from the ADVISE II Study and Inclusion in the SYNTAX2 Trial During Hot Line Late Breaking Clinical Trial Sessions at EuroPCR 2013 2Volcano Announces Preliminary Results from the ADVISE II Study and Inclusion in the SYNTAX2 Trial During Hot Line Late Breaking Clinical Trial Sessions at EuroPCR 2013 3Volcano Announces Preliminary Results from the ADVISE II Study and Inclusion in the SYNTAX2 Trial During Hot Line Late Breaking Clinical Trial Sessions at EuroPCR 2013 4Volcano Announces Preliminary Results from the ADVISE II Study and Inclusion in the SYNTAX2 Trial During Hot Line Late Breaking Clinical Trial Sessions at EuroPCR 2013 5
The major innovation in posterior stabilized (PS) knee design. Improve patellofemoral kinematics. Reduce wear rate potential. Increase resistance to posterior tibial dislocation. Achieve at least 120...
... uni-compartmental knee replacement is an exciting development ... procedure provides patients with a minimally invasive ... the knee often results in severe pain, ... life and even depression. Orthopedic surgeons have ...
... total knee prosthesis stems from many years ... and manufacturing technologies have been used in ... well as a favorable pressure distribution pattern ... wear to a minimum. The inherent design ...
Cemented hip system...
Medicine Products: