Navigation Links
Severe Sepsis Can Harm the Immune System
Date:12/20/2011

TUESDAY, Dec. 20 (HealthDay News) -- Severe sepsis can impair the immune system, a new study says.

Sepsis causes more than 225,000 deaths annually in the United States, the researchers said. "Developing new therapies for sepsis has been particularly challenging, with more than 25 unsuccessful drug trials," Jonathan S. Boomer, of the Washington University School of Medicine, St. Louis, and colleagues wrote as background information in the study. "Characterized by an initial intense inflammatory response or 'cytokine storm,' patients with sepsis may present with fever, shock, altered mental status, and organ dysfunction," they said.

"Whether this hyperinflammatory phase is followed by immunosuppression is controversial. Animal studies suggest that multiple immune defects occur in sepsis, but data from humans remain conflicting," the researchers noted.

Sepsis is a severe, systemic bacterial infection occurring in the body's blood system or tissues. It can be life-threatening, and patients require rapid treatment with intravenous antibiotics.

For the new study, researchers analyzed lung and spleen tissue from 40 intensive care unit patients, average age 72, who died with active severe sepsis and compared them to spleen and lung samples from a control group of 49 people, average age 53, who died without sepsis.

The median (midpoint) number of days in the ICU for patients with sepsis was 8, and the median duration of sepsis was 4 days.

Findings from biochemical tests and cell and tissue analyses for patients who died of sepsis were consistent with immune suppression, compared to the patients who did not have sepsis when they died.

The study appears Dec. 21 in the Journal of the American Medical Association.

With therapies improving, patients are more likely to survive sepsis, the researchers suggested, but may still have impaired immune systems, leaving them more susceptible to infections from organisms that wouldn't affect healthier people.

"The present study has a number of important therapeutic implications. Most investigative agents in sepsis have been directed at blocking inflammation and immune activation. Although such therapies may be successful if applied early, they may be harmful if applied later in the immuno-suppressive phase," the researchers wrote in a journal news release.

"An important part of implementing more targeted therapies will be to accurately determine the immune status of individual patients during their disease," the researchers concluded.

More information

The U.S. National Institute of General Medical Sciences has more about sepsis.

-- Robert Preidt

SOURCE: Journal of the American Medical Association, news release, Dec. 16, 2011


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Local Blood Supply Impacted by Wednesdays Severe Snow Storm
2. Severe sleep apnea decreases frequency of nightmare recall
3. Severe Sleep Apnea Has Silver Lining
4. H1N1 learnings: Risk factors for severe outcomes among patients admitted to hospital with H1N1
5. Obesity -- mild or severe -- raises kidney stone risk
6. Larynx preservation treatments result in low instance of severe voice disability, nutritional dysfunction
7. UM School of Medicine finds prenatal cocaine exposure not severely damaging to growth, learning
8. Severe Injuries From ATV Accidents on the Rise
9. CEIT-IK4 designs tool for operations on people with severe or profound auditory loss
10. Georgia Dentist Uncovers Obscure Law That Helps Dental Patients With Severe Anxiety
11. Stem Cells Might One Day Treat Severe Asthma
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Severe Sepsis Can Harm the Immune System
(Date:5/28/2016)... Aliso Viejo, California (PRWEB) , ... May 28, 2016 , ... ... just need to drag and drop a preset onto their media," said Christina Austin ... from Pixel Film Studios, editors can quickly and easily add stylish color grades to ...
(Date:5/27/2016)... ... 27, 2016 , ... Southland Log Homes , designer and manufacturer of ... kits, which can be found on its website at SouthlandLogHomes.com. , The designs of ... they highlight the craftsmanship of timber post and beam construction. The result is ...
(Date:5/27/2016)... New York, NY (PRWEB) , ... May 27, 2016 , ... ... the factors of a stroke, which we as a society can control and change. ... a stroke occurs nearly every 40 seconds within the United States. Plus, with an ...
(Date:5/27/2016)... (PRWEB) , ... May 27, 2016 , ... Aimed at ... human interest stories, which come courtesy of leaders in the nursing and health care ... from leading advocates and associations—namely Abilene Christian University. , As the nursing industry ...
(Date:5/26/2016)... Hampshire (PRWEB) , ... May 26, 2016 , ... ... care products, has been honored with a 2016 When Work Works Award for its ... award, part of the national When Work Works project administered by the Families and ...
Breaking Medicine News(10 mins):
(Date:5/27/2016)... the necessity of health literacy within the technology advancement of diagnostic imaging. According to a ... majority of oncology patients undergo imaging screenings without understanding the nuanced risks associated with ... ... ... Diagnostic Imaging Ampronix ...
(Date:5/27/2016)... Israel , May 27, 2016 ... of the Dario™ Diabetes Management Tool, today announced that the ... at the Marcum MicroCap Conference being held June 1-2 in ... Micro Invitational, being held June 7-9 in Los ... Ben-David will discuss recent corporate and operational milestones, including the ...
(Date:5/27/2016)... According to the 2016 report, ... ambulatory blood pressure monitoring system market growth. With aging, ... to respond to different pressure rates, leading to hypertension ... various cardiovascular disorders such as heart failure, stroke, coronary ... growing in prevalence each year. WHO estimates that 17 ...
Breaking Medicine Technology: