Navigation Links
Severe Sepsis Can Harm the Immune System
Date:12/20/2011

TUESDAY, Dec. 20 (HealthDay News) -- Severe sepsis can impair the immune system, a new study says.

Sepsis causes more than 225,000 deaths annually in the United States, the researchers said. "Developing new therapies for sepsis has been particularly challenging, with more than 25 unsuccessful drug trials," Jonathan S. Boomer, of the Washington University School of Medicine, St. Louis, and colleagues wrote as background information in the study. "Characterized by an initial intense inflammatory response or 'cytokine storm,' patients with sepsis may present with fever, shock, altered mental status, and organ dysfunction," they said.

"Whether this hyperinflammatory phase is followed by immunosuppression is controversial. Animal studies suggest that multiple immune defects occur in sepsis, but data from humans remain conflicting," the researchers noted.

Sepsis is a severe, systemic bacterial infection occurring in the body's blood system or tissues. It can be life-threatening, and patients require rapid treatment with intravenous antibiotics.

For the new study, researchers analyzed lung and spleen tissue from 40 intensive care unit patients, average age 72, who died with active severe sepsis and compared them to spleen and lung samples from a control group of 49 people, average age 53, who died without sepsis.

The median (midpoint) number of days in the ICU for patients with sepsis was 8, and the median duration of sepsis was 4 days.

Findings from biochemical tests and cell and tissue analyses for patients who died of sepsis were consistent with immune suppression, compared to the patients who did not have sepsis when they died.

The study appears Dec. 21 in the Journal of the American Medical Association.

With therapies improving, patients are more likely to survive sepsis, the researchers suggested, but may still have impaired immune systems, leaving them more susceptible to infections from organisms that wouldn't affect healthier people.

"The present study has a number of important therapeutic implications. Most investigative agents in sepsis have been directed at blocking inflammation and immune activation. Although such therapies may be successful if applied early, they may be harmful if applied later in the immuno-suppressive phase," the researchers wrote in a journal news release.

"An important part of implementing more targeted therapies will be to accurately determine the immune status of individual patients during their disease," the researchers concluded.

More information

The U.S. National Institute of General Medical Sciences has more about sepsis.

-- Robert Preidt

SOURCE: Journal of the American Medical Association, news release, Dec. 16, 2011


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Local Blood Supply Impacted by Wednesdays Severe Snow Storm
2. Severe sleep apnea decreases frequency of nightmare recall
3. Severe Sleep Apnea Has Silver Lining
4. H1N1 learnings: Risk factors for severe outcomes among patients admitted to hospital with H1N1
5. Obesity -- mild or severe -- raises kidney stone risk
6. Larynx preservation treatments result in low instance of severe voice disability, nutritional dysfunction
7. UM School of Medicine finds prenatal cocaine exposure not severely damaging to growth, learning
8. Severe Injuries From ATV Accidents on the Rise
9. CEIT-IK4 designs tool for operations on people with severe or profound auditory loss
10. Georgia Dentist Uncovers Obscure Law That Helps Dental Patients With Severe Anxiety
11. Stem Cells Might One Day Treat Severe Asthma
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Severe Sepsis Can Harm the Immune System
(Date:6/25/2016)... ... June 25, 2016 , ... The temporary closing of Bruton Memorial Library on June ... , brings up a new, often overlooked aspect of head lice: the parasite’s ability to ... is not a common occurrence, but a necessary one in the event that lice have ...
(Date:6/25/2016)... City, Oklahoma (PRWEB) , ... June 25, 2016 ... ... helping both athletes and non-athletes recover from injury. Recently, he has implemented orthobiologic ... the Oklahoma City area —Johnson is one of the first doctors to perform ...
(Date:6/24/2016)... ... June 24, 2016 , ... Those who have experienced traumatic events may suffer ... unhealthy avenues, such as drug or alcohol abuse, as a coping mechanism. To avoid ... healthy coping following a traumatic event. , Trauma sufferers tend to feel a range ...
(Date:6/24/2016)... ... ... Global law firm Greenberg Traurig, P.A. announced that 20 Florida attorneys are recognized ... this recognition are considered among the top 2 percent of lawyers practicing within the ... this year’s Legal Elite Hall of Fame: Miami Shareholders Mark D. Bloom, Burt ...
(Date:6/24/2016)... , ... June 24, 2016 , ... People across the ... Genome magazine’s Code Talker Award, an essay contest in which patients and their families ... to be presented at the 2016 National Society of Genetic Counselors (NSGC) Annual Education ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... VEGAS , June 26, 2016 ... to value-based care operating models within the health care ... enable greater financial efficiency , Deloitte offers a ... the key business issues impacting efficient cost optimization: labor ... , These services facilitate better outcomes and better ...
(Date:6/24/2016)... , June 24, 2016 ... Markets has announced the addition of the " ... offering. This ... and provides an updated review, including its applications in ... the total market, which includes three main industries: pharmaceutical ...
(Date:6/24/2016)... Research and Markets has announced the addition of ... report to their offering. ... The World Market for Companion Diagnostics covers the world market ... the report includes the following: , World ... Region (N. America, EU, ROW), 2015-2020 , World IVD ...
Breaking Medicine Technology: