Schering-Plough Announces European Submission of Fertility Medicine Corifollit...(/p Please discuss this with your docto...),Health

Please discuss this with your doctor, before starting treatment, especially if:

• you already know you have an increased risk of thrombosis
• you, or anyone in your immediate family, have ever had a thrombosis
• you are severely overweight.

Pregnancy and breast-feeding

Ask your doctor or pharmacist for advice before taking any medicine. You should not use PUREGON if you are already pregnant, or suspect that you might be pregnant, or if you are breast-feeding.

After treatment with gonadotropin preparations, there is an increased risk of having multiple pregnancies. Multiple pregnancies carry an increased health risk for both the mother and her babies around the time of birth. Furthermore, multiple pregnancies and characteristics of the patients undergoing fertility treatment (e.g. age of the female, sperm characteristics) may be associated with an increased risk of congenital abnormalities. There is a slightly increased risk of extra-uterine pregnancy in women with damaged fallopian tubes.

In women undergoing fertility treatment there may be a slightly higher risk of miscarriage.

Possible side effects

Like all medicines, PUREGON can cause side effects, although not everybody gets them.

Minor side effects include bruising, pain, redness, swelling and itching at the site of the injection. Occasionally, more widespread reactions like rash have been observed.

A complication with FSH treatment is unwanted overstimulation of the ovaries. This condition can become very serious, but the risk can be reduced by careful monitoring of follicle development during treatment. The first symptoms of ovarian overstimulation may be noticed as pain in the abdomen, feeling sick or diarrhoea. In more severe cases symptoms may include enlargement of the ovaries, accumulation o
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