Navigation Links
Same disease, different stem cell models
Date:5/6/2010

In the last three years, a new technique for reprogramming adult cells has given scientists an easier and less controversial way to harness the power of embryonic-like stem cells to study human disease from its earliest beginnings in hopes of gleaning new insights into the root causes of disease and developing new therapies.

But the reprogrammed cells, known as induced pluripotent stem (iPS) cells, are different from embryonic stem cells in their ability to model a human genetic disease, a new cell-to-cell comparison shows.

"This is the first example where we can clearly show induced pluripotent stem cells and embryonic stem cells behave differently in a disease model," said co-senior author George Daley, Director of the Stem Cell Transplantation Program at Children's Hospital Boston. Daley's team has turned patient cells back into stem cells for a range of diseases.

In the new study in the May 7 Cell Stem Cell, the researchers made iPS cells from the skin cells of three patients with fragile X syndrome, the most common form of inherited mental retardation in boys. By almost every measure, virtually the entire genome was dialed back in time. The key exception was the disease-causing gene, which becomes inactivated to cause the disease, and did not get turned back on in the iPS cells.

"Both iPS and embryonic stem cell lines have the same mutation," said co-senior author Nissim Benvenisty, director of the Stem Cell Unit at the Hebrew University of Jerusalem, whose lab established an embryonic stem cell model of fragile X syndrome three years ago at a time when such research was severely restricted in the United States. "However, we saw a difference between the two systems."

About one-third of children with fragile X have behavioral symptoms that overlap with autism. Scientists hope a stem cell model of fragile X will help them study what goes wrong and test drugs that may help treat both abnormal conditions.<
'/>"/>

Contact: Bess Andrews
elizabeth.andrews@childrens.harvard.edu
617-919-3110
Children's Hospital Boston
Source:Eurekalert

0

GOOD

Page: 1 2 3

Related medicine news :

1. Adolescent drinking adds to risk of breast disease, breast cancer
2. Plaque on CT scan is strong predictor of heart disease, worse long-term outcomes
3. Pancreatic cancer study reveals mechanism initiating disease, in mice
4. Pancreatic Cancer Study Reveals Mechanism Initiating Disease, In Mice
5. UW Symposium: How Disease, Therapy, Drugs and Meditation Reshape the Brain
6. Researcher to track spread of disease, malware and power outages
7. Select Topics in ALL: Molecular Characterization, Approaches to CNS Disease, and Post-remission Transplantation
8. Moderate Radiation Tied to Heart Disease, Stroke
9. Brain Develops Differently in Fragile X Syndrome
10. Popular diabetes drug works differently than thought
11. 21st Century Leadership: New Book Shows Why it's Different and How it Can Transform People and Organizations
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/26/2013)... The Office of Comptroller on the Currency (OCC) ... already cashed or deposited add up to $2.3 billion, ... poor practices continues, homeowners who find they have a ... as previous ones have. , "Many of the Independent ... face and make some really hard decisions along the way. ...
(Date:5/26/2013)... In the five years through 2013, revenue for the ... at an average annualized rate of 7.7% to $75.3 billion. ... prices as well as output growth, says IBISWorld. Poultry meat ... alternative to other meats. Additionally, poultry meat represents only 23.0% ... world average. And although pork is still the most popular ...
(Date:5/25/2013)... According to an article in the June ... nearly 30 million Americans tan indoors each year and an ... knowing the health risks. New research suggests that UV ... on the brains of some tanners (Go to goo.gl/hdwnz). ... I can’t say that I fully support this contention from ...
(Date:5/25/2013)... Chandler, AZ (PRWEB) May 25, 2013 ... whitening service page in partnership with JD Media Surge, ... whitening methods are now available and, depending on the ... home. During a routine visit, the best method will ... whitening is performed during a visit. A special peroxide-based ...
(Date:5/25/2013)... (HealthDay News) -- Many viruses and parasites that affect ... -- a bacteria-borne illness than can result in liver ... parks, according to a veterinarian. These germs ... the air, said Dr. Susan Nelson, a clinical associate ... of these serious diseases can be fatal, even with ...
Breaking Medicine News(10 mins):Health News:Independent Foreclosure Review Checks Cashed Or Deposited Successfully Total 2.3 Billion 2Health News:Independent Foreclosure Review Checks Cashed Or Deposited Successfully Total 2.3 Billion 3Health News:Independent Foreclosure Review Checks Cashed Or Deposited Successfully Total 2.3 Billion 4Health News:Poultry Farming Industry in China Industry Research Report – Now Available from IBISWorld 2Health News:Poultry Farming Industry in China Industry Research Report – Now Available from IBISWorld 3Health News:Sun Damage – Are UV Rays Addictive? 2Health News:Chandler Dentist Launches Teeth Whitening Service Page on Website in Partnership with JD Media Surge, LLC 2Health News:Hidden Dangers Dog Dog Parks 2
... FRAZER, Pa., April 30 Cephalon, Inc. (Nasdaq:,CEPH) ... Executive Vice,President and General Counsel. In this position, ... company, including those relating to commercial,and financial transactions, ... directly to Chairman and CEO, Frank,Baldino Jr., Ph.D., ...
... Pa., April 30 ViroPharma Incorporated,(Nasdaq: VPHM ) reported today ... Key events since December 31, 2007 include:, Development:, ... in stem cell transplant patients that enrollment ... May 2008; -- Patient enrollment continued in Phase 3 study ...
... Fla., April 30 Nihon LocalSoft, a ... the purpose of supporting US,Medical Device Manufactures ... entering the Japanese market, recently helped IRadimed,Corporation ... and localized embedded text for their operating ...
... Teeth,Whitening System(TM) has introduced an FDA cleared teeth ... look of discolored teeth. The company,created the procedure, ... addition to the spa experience. Now the process ... compromising the effectiveness,of the treatment., The Massage ...
... (NYSE: MYL ),today announced that in accordance with ... its quarterly dividend of $16.25 per,share (based on the ... $1,000.00 per share) payable on May 15, 2008, to ... 2008., Mylan Inc., with operations in more than ...
... Warner,Chilcott Limited (Nasdaq: WCRX ) today announced ... a securities class action lawsuit pending,in the United States ... suit asserted claims under the Securities Act of 1933 ... were allegedly damaged as a result of,acquiring the Company,s ...
Cached Medicine News:Health News:Cephalon Appoints Gerald J. Pappert as General Counsel 2Health News:Cephalon Appoints Gerald J. Pappert as General Counsel 3Health News:ViroPharma Incorporated Reports First Quarter 2008 Financial Results 2Health News:ViroPharma Incorporated Reports First Quarter 2008 Financial Results 3Health News:ViroPharma Incorporated Reports First Quarter 2008 Financial Results 4Health News:ViroPharma Incorporated Reports First Quarter 2008 Financial Results 5Health News:ViroPharma Incorporated Reports First Quarter 2008 Financial Results 6Health News:ViroPharma Incorporated Reports First Quarter 2008 Financial Results 7Health News:ViroPharma Incorporated Reports First Quarter 2008 Financial Results 8Health News:ViroPharma Incorporated Reports First Quarter 2008 Financial Results 9Health News:ViroPharma Incorporated Reports First Quarter 2008 Financial Results 10Health News:Nihon LocalSoft Designs New Japanese Software for IRadimed Corporation's Award-Winning MRidium MRI Infusion System 2Health News:Beautiful Teeth Not Just for the Dentist's Office Anymore / SpaBrite Teeth Whitening System(TM) Introduces Innovative, New Teeth Whitening Experience To Spas 2Health News:Warner Chilcott Announces Settlement of Securities Litigation 2Health News:Warner Chilcott Announces Settlement of Securities Litigation 3
(Date:5/24/2013)... , May 24, 2013  Sinovac Biotech ... provider of biopharmaceutical products in China ... operating subsidiary company of Sinovac, obtained the Certificate ... Certificate) from the China State and Food Administration ... bulk production plants, and its Changping filing and ...
(Date:5/23/2013)... de mayo de 2013  Volcano Corporation (NASDAQ: ... fabricante de herramientas de precisión para terapia guiadas ... la enfermedad vascular periférica y coronaria, anunció hoy ... enosine V asodilator I ndependent ... sesión de ensayo clínico hot line late breaking ...
(Date:5/23/2013)... health affects a man,s lifestyle, and if he wants to ... he should address any hearing loss he may be experiencing. ... Institute (BHI) is delivering to men around the country ... leads up to and includes Father,s Day. This year, National ... To help men address their hearing health ...
Breaking Medicine Technology:Sinovac Beijing Obtains China GMP Certificate Under the New GMP Guidelines 2Sinovac Beijing Obtains China GMP Certificate Under the New GMP Guidelines 3Volcano anuncia los resultados preliminares del estudio ADVISE II y su inclusión en el ensayo SYNTAX2 2Volcano anuncia los resultados preliminares del estudio ADVISE II y su inclusión en el ensayo SYNTAX2 3Volcano anuncia los resultados preliminares del estudio ADVISE II y su inclusión en el ensayo SYNTAX2 4Volcano anuncia los resultados preliminares del estudio ADVISE II y su inclusión en el ensayo SYNTAX2 5Volcano anuncia los resultados preliminares del estudio ADVISE II y su inclusión en el ensayo SYNTAX2 6Men Who Want to Stay Active, Feel Younger, and Remain Socially and Professionally Engaged Should Address Hearing Loss, BHI Advises 2Men Who Want to Stay Active, Feel Younger, and Remain Socially and Professionally Engaged Should Address Hearing Loss, BHI Advises 3Men Who Want to Stay Active, Feel Younger, and Remain Socially and Professionally Engaged Should Address Hearing Loss, BHI Advises 4
... 2011 , For the fourth year, the ... Awards for evidence-based psychosocial,interventions for people with dementia and ... better care and share best,practices. Applications can be submitted ... at http://www.alz.co.uk/award . Psychosocial research involves ...
... ClinStar, LLC, an established CRO providing clinical research ... Europe to the pharmaceutical and biotechnology industry, announced today ... East Coast of the United States. ... US location to its headquarters in San Francisco, CA, ...
Cached Medicine Technology:4th Alzheimer's Awards Announced in Search of Global Solutions for Better Dementia Care 2ClinStar, LLC Establishes New Office on the US East Coast 2
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
Medicine Products: