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Researchers pinpoint key stem cells for eating and sex
Date:7/21/2010

s the nasal epitheliumthe sheet of nerve cells that lines the nasal cavity. The researchers studied these tissues using molecular markers to distinguish different classes of cells and recombinant DNA technology as well as mutant mice to assess how several key genes define olfactory stem cell identity. They found a subset of cells that divide slowly and symmetricallysuggesting that these were indeed, the stem cells. They also showed that these cells were self renewinganother essential characteristic of stem cells. They defined several molecules that influence whether these stem cells remain as stem cells or divide terminally to make olfactory, vomeronasal and GnRH neurons. Finally, they showed that these stem cells uniquely give rise to ORNs, VRNs, and GnRH neurons.


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Contact: Anne Banner
mcmacb@gwumc.edu
202-994-2261
George Washington University Medical Center
Source:Eurekalert

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