Navigation Links
Researchers pinpoint key stem cells for eating and sex
Date:7/21/2010

WASHINGTON New research, published in the journal Development, by Dr. Anthony-Samuel LaMantia, professor of Pharmacology & Physiology and director of the newly formed GW Institute for Neuroscience, and his colleagues have identified the stem cells that generate three critical classes of nerve cells olfactory receptors (ORNs), vomeronasal (VRNs) and gonadotropin releasing hormone (GnRH) neurons that are responsible for enabling animals and humans, to eat, interact socially and reproduce.

This research is the first evidence identfying these stem cells. By studying mice at the earliest stages of embryonic development, LaMantia and his colleagues were able to identify the location of these cells, confirm that they divide slowly and symmetricallythus making more stem cells, have a distinct molecular identity, and give rise to all cell types in the tissueincluding ORNs, VRNs and GnRH neurons. These embryonic olfactory stem cells also are ultimately responsible for generating stem cells that remain in the lining of the nose throughout life and make new ORNs and VRNs. Thus these stem cells are also essential to enable a rare example of nervous system regeneration that continues throughout life.

"By identifying these stems cells, our research will help physicians understand why people have certain genetic, neurological, and mental disabilities. Olfaction is often compromised early in the course of a number of serious diseases including autism, schizophrenia, and Alzheimer's disease, and GnRH deficiency is important in many cases of infertility. It is my hope that in the future, we will combine this sort of cell and molecular biology with clinical practice to develop better treatments for patients with these disorders," said Dr. LaMantia.

To identify the early olfactory stem cell, Dr. LaMantia and his colleagues used multiple methods to define the identity and potential of dividing cells in the embryonic tissue that eventually becomes the nasal epitheliumthe sheet of nerve cells that lines the nasal cavity. The researchers studied these tissues using molecular markers to distinguish different classes of cells and recombinant DNA technology as well as mutant mice to assess how several key genes define olfactory stem cell identity. They found a subset of cells that divide slowly and symmetricallysuggesting that these were indeed, the stem cells. They also showed that these cells were self renewinganother essential characteristic of stem cells. They defined several molecules that influence whether these stem cells remain as stem cells or divide terminally to make olfactory, vomeronasal and GnRH neurons. Finally, they showed that these stem cells uniquely give rise to ORNs, VRNs, and GnRH neurons.


'/>"/>

Contact: Anne Banner
mcmacb@gwumc.edu
202-994-2261
George Washington University Medical Center
Source:Eurekalert

Related medicine news :

1. BUSPH researchers link widely used chemicals to ADHD in children
2. Researchers Use Ecstasy to Treat PTSD
3. UC San Diego researchers find cause of metabolic disease -- and possible cure
4. Researchers cut years from drug development with nanoscopic bead technology
5. Researchers study relationship of oral cancers and periodontal disease
6. HIV care providers and researchers applaud release of national HIV/AIDS strategy
7. Researchers envision better disease surveillance to improve public health
8. U-M researchers identify gene mutation that causes rare form of deafness
9. MIT researchers find that Sirtuin1 may boost memory and learning ability
10. Researchers identify factors behind blood-making stem cells
11. Parkinsons Transplant Mystery Solved, Researchers Say
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/26/2017)... ... April 26, 2017 , ... The National Business Research ... National Registry of Emergency Medical Technicians and welcomes this organization to the ... Jan G. West, Ph.D. , CEO & Organizational Psychologist at NBRI. “This award ...
(Date:4/26/2017)... ... April 26, 2017 , ... RawTrition now brings you BioEnergy which ... nutrients from SUPERFOODS! , RawTrition is taking nutrients to the next level! ... the body recognizes its raw form (unlike the synthetically made options that are on ...
(Date:4/26/2017)... Doylestown, Pa. (PRWEB) , ... ... ... Solutions division, which provides an agile ecosystem and domain expertise for sponsors ... end-to-end, configurable randomization and trial supply management (RTSM) software platform. Bioclinica ...
(Date:4/25/2017)... ... April 25, 2017 , ... Splashtop ... Mirroring360 Pro . This new addition to the Mirroring360 product family combines device ... business. , Mirroring360 Pro enables educators, business professionals and individuals to stream or ...
(Date:4/25/2017)... ... April 25, 2017 , ... A stressful work environment can hurt the ... overall productivity and performance in the workplace. The goal of Clearview Resolution Services has ... weeks of April, Clearview Resolution Services will be shutting down the office early on ...
Breaking Medicine News(10 mins):
(Date:4/19/2017)... , April 19, 2017  Sorrento Therapeutics, Inc. ... clinical-stage biopharmaceutical company developing new treatments for cancer ... closing of its previously announced underwritten public offering ... a public offering price of $2.00 per share, ... offering expenses payable by Sorrento.  The net proceeds ...
(Date:4/19/2017)... , April 19, 2017  SARES•REGIS Group ... it is developing at Conejo Spectrum Business Park ... to Atara Biotherapeutics, Inc. , a biopharmaceutical ... and life-threatening diseases that have been underserved by ... T-cell therapies for cancer, autoimmune and infectious disease. ...
(Date:4/18/2017)... April 18, 2017 Research and Markets has ... report to their offering. ... The global arthroscopy devices market to grow at a CAGR of ... Arthroscopy Devices Market 2017-2021, has been prepared based on an in-depth ... market landscape and its growth prospects over the coming years. The ...
Breaking Medicine Technology: