Navigation Links
Protein plays unexpected role protecting chromosome tips
Date:8/13/2009

HOUSTON - A protein specialist that opens the genomic door for DNA repair and gene expression also turns out to be a multi-tasking workhorse that protects the tips of chromosomes and dabbles in a protein-destruction complex, a team lead by researchers at The University of Texas M. D. Anderson Cancer Center reports in the Aug. 13 edition of Molecular Cell.

"Instead of being a really important tool dedicated just to regulation of gene transcription, Gcn5 is more like a Swiss Army knife that performs different functions depending on what needs to be done in the cell," said senior author Sharon Dent, Ph.D., professor in M. D. Anderson's Department of Biochemistry and Molecular Biology.

The researchers document a chain of events that starts with depletion of Gcn5, which leads to decreased activity by another protein that protects yet a third protein from destruction. That last protein, TRF1, protects telomeres, dense structures at the end of chromosomes which, like the compressed plastic tips on the ends of a shoelace, keep the chromosome ends intact.

Variation in the gene that expresses the middle protein in this model, ubiquitin specific protease 22 (USP22), is part of an 11-gene signature associated with highly metastatic cancers and poor prognosis, the authors note.

"Our results indicate that the Gcn5 complex regulates not just gene transcription but also protein stability," Dent said. "They also suggest that the role of USP22 in highly aggressive cancers might be due to these new functions."

Telltale telomere damage

Chromosomes are made of DNA that is tightly intertwined with proteins called histones to form chromatin. Chromatin is a condensed structure that forms a natural barrier inhibiting access to DNA. Gcn5 was previously known for its role in a complex of proteins that loosens chromatin to allow access to DNA by the cell's DNA repair machinery and by transcription factors that launch t
'/>"/>

Contact: Scott Merville
smerville@mdanderson.org
713-792-0661
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert  

0

GOOD

Page: 1 2 3

Related medicine news :

1. Draining away brains toxic protein to stop Alzheimers
2. Penn study finds pro-death proteins required to regulate healthy immune function
3. New prion protein discovered by Canadian scientists may offer insight into mad cow disease
4. Emory researchers identify signaling protein for multiple myeloma
5. Human C-reactive protein regulates myeloma tumor cell growth and survival
6. Lowering Blood Protein Wont Help Kidney Patients
7. Blood protein detects lung cancer, even at earliest stage
8. Natural Protein Could Help Spot, Treat Liver Cancer
9. Heat shock proteins are co-opted for cancer
10. How adhesive protein causes malaria
11. Loss of gene leads to protein splicing and buildup of toxic proteins in neurons
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Protein plays unexpected role protecting chromosome tips
(Date:5/18/2013)... 2013 The Ayurvedic practitioner program will ... in the West. Program is available in Mexico via ... a healing modality practiced for over 5,000 years. In ... that health begins when an individual lives in harmony ... individual needs. Ayurveda aims to heal an individual in ...
(Date:5/18/2013)... May 18, 2013 Dr. Robert Tracey, an ... dentistry, employs his knowledge of the root causes of ... patients. With May being Better Sleep Month, Dr. Tracey points ... of chronic sleep disorder, and sleep apnea is one of ... a person will essentially stop breathing at different times while ...
(Date:5/18/2013)... Wine World Accessories, a renowned online store for ... 25% discount on Franmara Dynamo Electric Wine Bottle ... this electric corkscrew opener for $44.95 via Wine World ... store ensures delivery of their items within 1-2 business ... A spokesperson from the online store elaborates the features ...
(Date:5/18/2013)... (PRWEB) May 18, 2013 Creation's Gold ... weight loss supplement, which features unmatched potency and purity ... Gold was set up to provide the very best ... work to achieve their wellness goals. The goal is ... lead happier, healthier lives. We started by supplying only ...
(Date:5/17/2013)... 17, 2013 Allen J. Schultz, D.D.S., is ... disease treatment available to residents of San Juan Capistrano. ... diseased tissue rather than relying on a scalpel to cut ... laser that works on tightly defined wavelengths to target the ... tissue intact. , Only about one in every hundred dental ...
Breaking Medicine News(10 mins):Health News:Ayurveda Training in Mexico Offered by Escuela de Ayurveda de California, a Leading Institution in the West 2Health News:Pomona, NY Dentist, Dr. Robert Tracey of General & Laser Assisted Dentistry (GLAD) Highlights Sleep Apnea Dentistry Services for Better Sleep Month 2Health News:Pomona, NY Dentist, Dr. Robert Tracey of General & Laser Assisted Dentistry (GLAD) Highlights Sleep Apnea Dentistry Services for Better Sleep Month 3Health News:Now Save 25% on Franmara Dynamo Electric Wine Bottle Opener at Wine World Accessories 2Health News:Creation's Gold Launches Potent Garcinia Cambogia Supplement for Weight Loss 2Health News:San Clemente, CA Periodontist, Dr. Allen J. Schultz, Now Provides Laser Gum Disease Treatment to Southern Orange County Periodontal Disease Patients 2
... Oct. 16 International SOS Assistance, Inc. today ... services to the Department of Defense TRICARE Overseas Program. Since ... duty service members and their families receive the highest quality ... outside the United States and Puerto Rico. , ...
... given early in pregnancy might save infants most at ... -- U.S. researchers are testing a new approach in ... while they,re still in the womb. , The new ... cells that have been treated to speed and improve ...
... , SAN ANTONIO, Oct. 16 The National Trauma ... research in the United States, announced its first Request ... potential to change medical practice and save lives. , ... or translational research to take place in 2010. "Historically, ...
... Oct. 16 Amgen (Nasdaq: AMGN ) and ... data about ENBREL being presented at the 2009 American ... from Oct. 17-21, 2009. These presentations contribute to data ... , "The clinical data being presented at ACR ...
... for discussing the latest updates, information on H1N1/Swine flu , ... invited to submit questions for inclusion in a two-part tweet chat ... 10 a.m. - noon on Twitter. , Sandro Cinti, M.D., ... and VA Ann Arbor Healthcare System, will answer questions during part ...
... The European Society of Cardiology wishes to comment on ... authorise the sale of cigarettes on the internet, to ... denies that this is the intention, the news is ... last year,s smoking ban. ESC spokesperson Professeur Ph.Gabriel ...
Cached Medicine News:Health News:International SOS Awarded TRICARE Overseas Program Contract 2Health News:Transplant May Treat Metabolic Disorders in Womb 2Health News:National Trauma Institute Announces $600,000 in Funding for Trauma Research 2Health News:Enbrel(R) (etanercept) Data to be Presented at the 2009 American College of Rheumatology Scientific Meeting 2Health News:Enbrel(R) (etanercept) Data to be Presented at the 2009 American College of Rheumatology Scientific Meeting 3Health News:Enbrel(R) (etanercept) Data to be Presented at the 2009 American College of Rheumatology Scientific Meeting 4Health News:Enbrel(R) (etanercept) Data to be Presented at the 2009 American College of Rheumatology Scientific Meeting 5Health News:Enbrel(R) (etanercept) Data to be Presented at the 2009 American College of Rheumatology Scientific Meeting 6Health News:Enbrel(R) (etanercept) Data to be Presented at the 2009 American College of Rheumatology Scientific Meeting 7Health News:Enbrel(R) (etanercept) Data to be Presented at the 2009 American College of Rheumatology Scientific Meeting 8Health News:Enbrel(R) (etanercept) Data to be Presented at the 2009 American College of Rheumatology Scientific Meeting 9Health News:ESC press statement : Cigarettes on sale on the internet 2Health News:ESC press statement : Cigarettes on sale on the internet 3
(Date:5/17/2013)... , Puerto Rico , May 17, ... central and western Puerto Rico , Caribbean ... PR) Center has improved its radiation therapy capabilities with the ... Puerto Rico . Versa HD offers clinicians ... range of tumors throughout the body, while also enabling treatment ...
(Date:5/17/2013)... , May 17, 2013  PENTAX Medical, a ... Medical, a global leader in ultrasound imaging, recently ... companies to enable further innovation in the development ... Hitachi-Aloka ultrasound systems and PENTAX Medical endoscopic portfolio ... families of EUS systems. This agreement will continue ...
(Date:5/17/2013)... May 17, 2013 Oramed Pharmaceuticals ... oral drug delivery systems, announced today that the United ... Company,s Investigational New Drug application(IND) for ORMD-0801, its oral ... have the FDA clearance to proceed," stated ... trial is a major milestone for Oramed and we ...
Breaking Medicine Technology:Puerto Rico's Caribbean Imaging and Radiation Therapy Center Orders Elekta's New Versa HD System for Treatment of Cancer Patients 2PENTAX Medical And Hitachi-Aloka Medical Continue Joint Innovation And Global Leadership In Endoscopic Ultrasound Systems 2PENTAX Medical And Hitachi-Aloka Medical Continue Joint Innovation And Global Leadership In Endoscopic Ultrasound Systems 3Oramed Receives FDA Clearance to Initiate Oral Insulin Trials in the U.S. 2Oramed Receives FDA Clearance to Initiate Oral Insulin Trials in the U.S. 3
... , LISBON, Portugal, September 11 ... Confirms Superiority of the New Intranasal Treatment,for Breakthrough Cancer Pain ... today further demonstrate the efficacy of Instanyl in,management of breakthrough ... of the European Federation of Chapters of the International,Association for ...
... , THOUSAND OAKS, Calif., Sept. 10 ... new data will be presented on the burden of osteoporosis, ... American Society for Bone and Mineral Research (ASBMR) annual meeting ... being evaluated by regulatory bodies in the United States (U.S.), ...
Cached Medicine Technology:Instanyl(R) (intranasal fentanyl spray) Sets New Standard in Management of Breakthrough Cancer Pain 2Instanyl(R) (intranasal fentanyl spray) Sets New Standard in Management of Breakthrough Cancer Pain 3Instanyl(R) (intranasal fentanyl spray) Sets New Standard in Management of Breakthrough Cancer Pain 4Amgen Highlights Data to be Presented at American Society for Bone and Mineral Research (ASBMR) Meeting 2Amgen Highlights Data to be Presented at American Society for Bone and Mineral Research (ASBMR) Meeting 3Amgen Highlights Data to be Presented at American Society for Bone and Mineral Research (ASBMR) Meeting 4Amgen Highlights Data to be Presented at American Society for Bone and Mineral Research (ASBMR) Meeting 5Amgen Highlights Data to be Presented at American Society for Bone and Mineral Research (ASBMR) Meeting 6Amgen Highlights Data to be Presented at American Society for Bone and Mineral Research (ASBMR) Meeting 7Amgen Highlights Data to be Presented at American Society for Bone and Mineral Research (ASBMR) Meeting 8
The Petite leads are low profile (4.8F lead body diameter) implantable endocardial pacing leads which are manufactured using a new proprietary hexafilar coil for permanent stimulation of the ventricl...
... The Guidant Flextend ... transvenous pace/sense lead with ... The extendable/retractable helix design ... possibilities for permanent implantation ...
The CapSure Z Novus is an endocardial, tined, high-efficiency lead. High efficiency combined with steroid elution allows safe, low output programming....
The Vitatron Excellence S+ lead series are endocardial leads providing excellent reliability and optimal pacing characteristics....
Medicine Products: