Navigation Links
Prognostic model developed for MDS related to prior cancer therapy
Date:12/13/2011

SAN DIEGO - A large-scale analysis of patients whose myelodysplastic syndrome is related to earlier cancer treatment overturns the notion that all of them have a poor prognosis, researchers from The University of Texas MD Anderson Cancer Center report at the 53rd Annual Meeting of the American Society of Hematology.

"MDS patients whose disease springs from earlier radiation, chemotherapy or both treatments are usually told that they have a poor prognosis. But by analyzing survival risk factors in a large patient population, we've found these patients fall into good, intermediate and poor prognostic groups," said study leader Guillermo Garcia-Manero, M.D., Ph.D., professor in MD Anderson's Department of Leukemia.

Understanding their differing characteristics will better inform treatment decisions for these patients, Garcia-Manero said.

Myelodysplastic syndrome consists of a group of diseases in which the bone marrow progenitor cells that normally morph into red and white blood cells and platelets fail to respond to normal growth controls. That results in too many progenitor cells (also known as blasts) and too few mature blood cells, and in about 30 percent of patients, the disease progresses to acute myeloid leukemia (AML).

Treatment-related MDS is often more resistant to therapy

Therapy-related MDS generally differs from other MDS cases by having more chromosomal abnormalities, a higher rate of conversions to acute myeloid leukemia and high resistance to standard MDS therapy. Even so, Garcia-Manero notes, a one-size-fits-all poor prognosis is not accurate.

The research team analyzed 1,950 MD Anderson patients treated between 1998 and 2007. It found 438 had a history of one or more previous cancers that were treated before their MDS diagnosis. Of these, 279 cases who had received chemotherapy, radiotherapy or both were analyzed.

A first round of analysis identified at least 15 factors a
'/>"/>

Contact: Scott Merville
smerville@mdanderson.org
713-516-4855
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Strong evidence supports prognostic value of circulating tumor cells in breast cancer
2. A novel prognostic marker for biliary atresia
3. Prognostic markers for prostate cancer patients who receive radiation after surgery
4. A prognostic and predictive biomarker for nonsmall cell lung cancer
5. "IPGDx, LLC Announces The Continued Validation Of Its Patented Technology For The Assessment Of Prognosis; PrognostiCheck" Getting the New Information to Patients and Do
6. Model shows how façade pollutants make it into the environment
7. Supercomputer reveals new details behind drug-processing protein model
8. Funding models not associated with better preventive care delivery
9. When errors improve performance: Model describes how experiences influence our perception
10. New Stanford model establishes guidelines for earlier cancer detection
11. UGA researchers develop first mouse model to study important aspect of Alzheimer’s
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Prognostic model developed for MDS related to prior cancer therapy
(Date:11/28/2014)... (PRWEB) November 28, 2014 talklocal ... consumers to the right service professionals by phone in about ... after at least two tornadoes were reported to have touched ... no damage was reported following the tornadoes, Denver residents now ... the unexpected. Having TalkLocal is like having local pros in ...
(Date:11/28/2014)... November 28, 2014 TheBeautyPlace.com ... lowering prices and offering savings in abundance this ... care, hair loss and cosmetic products such as ... Bosley, TheBeautyPlace.com offers competitive discounts on already reduced ... at affordable prices giving customers savings year round. ...
(Date:11/27/2014)... iFitDress.com, a reliable company of women’s special occasion dresses, ... black cocktail dresses . The new models come ... are priced under $50. All customers who purchase the ... low shipping fee before Dec. 30, 2014. , iFitDress.com ... business has promised to offer only high quality special ...
(Date:11/27/2014)... November 27, 2014 TORQ Cycle is not ... instructors who go out of the way to help their ... to get fit and do their workouts sincerely using ... understand the fact that it is important for people to ... year, they have made sure that people take to fitness ...
(Date:11/27/2014)... According to a recent report by iData ... into the surgical robotics market may find ... MIS field dominated by Intuitive. These companies are expected ... market by 2020. , “The MIS robotic device ... and President of iData. “System sales for the da ...
Breaking Medicine News(10 mins):Health News:TalkLocal Launches In Denver A Week After Multiple Tornadoes Hit Near City 2Health News:TheBeautyPlace.com Announces Double Savings 2Health News:Beautiful Black Cocktail Dresses Offered by Top Dress Supplier iFitDress.com 2Health News:The new wave in Fitness : Stay Active with Innovative Indoor Cycling Programs 2Health News:U.S. Robotic Surgery Market Set to Diversify and Grow: Intuitive Surgical’s ‘da Vinci’ Robot Revenues to Increasingly Rely On Procedures and Services 2
... on legislation that would cut $268 million,from Medicare ... Seniors across Minnesota,are speaking out against proposed ... considered in the U.S. Senate. The legislation (H.R.,6331) ... program in,Minnesota alone and severely cut back the ...
... July 9 Zeus Scientific, Inc. today,announced its ... for,methicillin-resistant Staphylococcus aureus (MRSA). The test is based ... nucleic acid,amplification of a target pathogen., Available ... MRSA,test will enable healthcare professionals to identify carriers ...
... PA (July 9, 2008)Dr. Lee Kern, program coordinator ... College of Education in Bethlehem, Pa., will lead ... Research and Development Center on Serious Behavior Disorders ... received a highly competitive $9.6 million grant from ...
... a lot of time on the Internet, study shows, , , WEDNESDAY, ... lot of time on the Internet are more likely to see ... in front of the computer screen, new research shows. , And ... the researchers accounted for the amount of exercise the girls were ...
... The HealthCentral,Network, Inc. (http://www.HealthCentral.com ) has ... resource,committed to helping and informing those struggling ... with offering a place to discuss and,post ... Pennsylvania clinical instruction,Dr. Jeffrey Heit, television health ...
... Judy Bachrach Launches Newly, Redesigned Advice Column and Public Forum for the ... ... 9 (ZealousPR) -- Today, http://www.thecheckoutline.org - the first-ever online advice ... will appear with a,bold new design and a new easily accessible FORUM ...
Cached Medicine News:Health News:Minnesota Seniors Speak Out Against Medicare Advantage Cuts 2Health News:Lehigh to lead $9.6M national research center for serious behavior disorders 2Health News:Lehigh to lead $9.6M national research center for serious behavior disorders 3Health News:Surfing to a Higher Weight 2Health News:Surfing to a Higher Weight 3Health News:Responding to Increased Incidence of Obesity and Associated Health Issues, The HealthCentral Network Launches Site to Support those Struggling with Weight 2Health News:Online Advice Column Receives Critical Acclaim; Baby Boomers Found Resourceful During Crisis 2
(Date:11/26/2014)... RADNOR, Pa. , Nov. 26, 2014 ... dedicated to the development of innovative transdermal synthetic cannabinoid ... the Piper Jaffray 26th Annual Healthcare Conference 2014. The ... the New York Palace in New York ... , will present at 4:50 pm on Tuesday, December ...
(Date:11/26/2014)... -- According to the new research ... Battery, Pneumatic), by Product (Drill, Saw, Stapler, Reamer, ... (Orthopedic, ENT, Oral, Thoracic, Neurology) - Global Forecasts ... Instruments Market is estimated to be worth around ... expected to grow at a moderate CAGR during ...
(Date:11/26/2014)... , Nov. 25, 2014 Nanomix ... on the development of mobile diagnostic tests ... in hospital and pre-hospital settings, today announced ... 13485:2003 certification.  The certification was awarded by ... the world,s leading certification bodies. ...
Breaking Medicine Technology:Zynerba Pharmaceuticals to Present at Piper Jaffray 26th Annual Healthcare Conference 2014 2Powered Surgical Instruments Market Worth $2.1 Billion by 2019 2Powered Surgical Instruments Market Worth $2.1 Billion by 2019 3Powered Surgical Instruments Market Worth $2.1 Billion by 2019 4Nanomix Receives ISO 13485:2003 Certification 2
... 4, 2011 Roche (SIX: RO, ROG; OTCQX: RHHBY) announced ... North America beyond physician offices and outpatient clinics with the ... and reference laboratories. The new line is expected to be ... regulatory approval and other requirements. Roche Diagnostics ...
... CLEMENTE, Calif., Oct. 4, 2011 ReShape Medical®, Inc. ... and chief executive officer.  Interim CEO, Ken Charhut, will ... chairman of the board for ReShape Medical.   ... and CEO of Luminous Medical, Inc., an innovative glucose ...
Cached Medicine Technology:Roche to Expand Coagulation Testing Portfolio, Develop New Systems for Diagnostic Laboratories in US and Canada by 2014 2ReShape Medical Names Richard Thompson President and Chief Executive Officer 2
... Cronin, Inc. is a ... Footwear, Orthopedic Softgoods, and ... Our products are of ... available in the USA ...
... Thumb Spica Splint provides effective long-term ... custom fit. Adjustable radial and palmar ... for Gamekeper's thumb, de Quervain's, scaphoid ... closure straps.,FormFit™ Splints offer superior fit ...
Qualcare™ Thumb Spica...
... QuickCast® Cast-like splints Slip on, ... and QuickCast conforms to fit. ... Reheat to adjust and reposition. ... with a temperature-sensitive polymer Straps ...
Medicine Products: