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Princeton technique puts chemistry breakthroughs on the fast track
Date:11/28/2011

Scientists can now take that "a-ha" moment to go with a method Princeton University researchers developed and successfully tested to speed up the chances of an unexpected yet groundbreaking chemical discovery.

The researchers report this month in the journal Science a technique to accomplish "accelerated serendipity" by using robotics to perform more than 1,000 chemical reactions a day with molecules never before combined. In a single day of trials, the Princeton researchers discovered a shortcut for producing pharmaceutical-like compounds that shaves weeks off the traditional process, the researchers report.

The basis of the research was to combine new technology with a unique, rapid-reaction approach that could allow chemists to explore unheard-of and potentially important chemical combinations without devoting years to the pursuit, explained senior researcher and co-author David MacMillan, the James S. McDonnell Distinguished University Professor of Chemistry at Princeton and chair of the department. MacMillan worked with lead author Andrew McNally, a research associate in MacMillan's lab, and Princeton graduate student and co-author Christopher Prier.

"This is a very different way of approaching how we come up with valuable chemical reactions," MacMillan said.

"Our process is designed specifically for serendipity to occur. The molecules that should be combined are those for which the result is unknown," he said. "In our lab, we used this technique to make new findings in a much more routine and rapid fashion, and we show that if you have enough events involved, serendipity won't be rare. In fact, you can enable it to happen on almost a daily basis."

The MacMillan lab's technique does more than just expedite the discovery process the researchers actually developed a unique framework for creating new materials or finding better ways of producing existing ones, said Stephen Buchwald, a professor of chemist
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Contact: Morgan Kelly
mgnkelly@princeton.edu
609-258-5729
Princeton University
Source:Eurekalert

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