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Pediatric brain tumors
Date:9/19/2011

Medulloblastomas constitute the most frequent class of malignant childhood brain tumor. Tumors of this type arise due to the uncontrolled proliferation of immature nerve cells in the developing brain, and there is no targeted treatment available. A research team based at LMU's Center for Neuropathology and Prion Research and led by Privatdozent Dr. Ulrich Schller has now demonstrated that the regulatory protein FoxM1 is essential for the continued growth of these tumor cells. Moreover, the level of FoxM1 expressed in the cells is significantly, and negatively, correlated with a patient's survival time. The protein therefore provides a useful prognostic marker, which should allow oncologists to gauge the malignancy of tumors and select the most effective therapeutic strategy for the individual patient. Furthermore, FoxM1 may provide a novel point of attack for the development of new ways to treat the condition. Schller and his team were able to reduce FoxM1 levels in tumor cells by exposing them to the antibiotic siomycin A, and showed that the drug also inhibits tumor growth. "If further work on laboratory cell cultures and in living organisms confirms these results, siomycin could turn out to be an effective drug for the treatment of medulloblastoma," Schller says. (Clinical Cancer Research, published OnlineFirst 14.September 2011)

Research conducted over the past 10 years has shown that medulloblastomas arise as a result of aberrant activation of certain molecular signaling pathways. Schller and his team set out to determine whether the transcription factor FoxM1 plays a role in supporting the growth of this type of tumor and, if so, whether it might serve as a drug target for the development of an effective therapy for the disease.

Transcription factors determine the suite of proteins present in a given cell by defining which of the genes encoded in the genomic DNA are transcribed into RNA copies that can program protein synthesis. Th
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Contact: Dr. Kathrin Bilgeri
kathrin.bilgeri@lmu.de
49-892-180-6938
Ludwig-Maximilians-Universitt Mnchen
Source:Eurekalert

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