Navigation Links
pH-sensitive liposomal cisplatin improves peritoneal carcinomatosis treatment without side-effects
Date:8/27/2012

Scientists at the Oswaldo Cruz Foundation and Federal University of Minas Gerais, led by Dr. Andra Teixeira-Carvalho and Dr. Mnica Cristina de Oliveira, have developed and characterized a circulating and pH-sensitive liposome containing cisplatin (SpHL-CDDP) aiming to promote the release of cisplatin near the tumor as well as decreasing toxicity. The development of analog drugs and new formulations are current strategies for increasing the effectiveness and safety of cisplatin as an anti-peritoneal carcinomatosis drug. The results, which appear in the August 2012 issue of Experimental Biology and Medicine demonstrate that the treatment of initial or disseminated Ehrlich ascitic tumor-bearing Swiss mice with SpHL-CDDP improved the antitumor efficacy and decreased renal and bone marrow toxicity of cisplatin-based therapy.

"Peritoneal carcinomatosis is a serious concern in the treatment of abdominal tumors such as hepatic, gastric and gynecological tumors", says Dr. Oliveira. "The strategy of local chemotherapy is interesting due to the possibility to increase the therapeutic efficacy while minimizing systemic side-effects. SpHL-CDDP treatment was able to reduce cancer cell proliferation and increase survival, in the animal model, with no known toxicity clinical signs found in the free CDDP treatment." says Dr. Maroni.

These results open the possibility of future use of SpHL-CDDP in chemotherapy of peritoneal carcinomatosis. "New studies are underway in our research group to investigate the signaling pathways of cell death as well as use of high doses of SpHL-CDDP for the treatment of peritoneal carcinomatosis", says Dr. Teixeira-Carvalho.

Dr. Steven R. Goodman, Editor-in-Chief of Experimental Biology and Medicine, said " This very interesting study has utilized a new pH-sensitive circulating liposome containing cisplatin formulation which decreased cancer proliferation and drug toxicity in a mouse model. This provides the basis for further translational testing of this formulation leading to clinical trials aimed at more effective treatment of abdominal tumors".


'/>"/>

Contact: Andrea Teixeira Carvalho
atcteixeira@gmail.com
Society for Experimental Biology and Medicine
Source:Eurekalert

Related medicine news :

1. Clinical insight improves treatment with new lung cancer drug
2. Normalizing tumor blood vessels improves delivery of only the smallest nanomedicines
3. Exercise improves quality of life during breast cancer treatment
4. Early treatment improves outcomes in rare, often undiagnosed form of encephalitis
5. NYUCNs Dr. Laura Wagner: Study finds accreditation improves safety culture at nursing homes
6. Brief training program improves resident physicians empathy with patients
7. A nurse practitioner-driven palliative care intervention improves cancer patients quality of life
8. Oxytocin improves brain function in children with autism
9. Nordic walking improves health of heart failure patients
10. Donor aortic graft improves reconstruction after partial laryngectomy
11. Vitamin C improves pulmonary function in newborns of pregnant smoking women
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/24/2016)... ... June 24, 2016 , ... June 19, 2016 is World ... with chronic pain and the benefits of holistic treatments, Serenity Recovery Center ... with Sickle Cell Disease. , Sickle Cell Disease (SCD) is a disorder of the ...
(Date:6/24/2016)... ... June 24, 2016 , ... Global law firm Greenberg ... Legal Elite. The attorneys chosen by their peers for this recognition are considered among ... Greenberg Traurig Shareholders received special honors as members of this year’s Legal Elite Hall ...
(Date:6/24/2016)... ... ... of Topricin and MyPainAway Pain Relief Products, join The ‘Business for a Fair Minimum Wage’ ... 2020 and then adjusting it yearly to increase at the same rate as the median ... floor does not erode again, and make future increases more predictable. , The company is ...
(Date:6/24/2016)... ... June 24, 2016 , ... The ... recognize Dr. Barry M. Weintraub as a prominent plastic surgeon and the network’s ... the world, and the most handsome men, look naturally attractive. Plastic surgery should ...
(Date:6/24/2016)... ... June 24, 2016 , ... National recruitment firm Slone Partners is ... sequencing and genomics experience, as Vice President of North American Capital Sales at ... for leading the sales team in the commercialization of the HTG EdgeSeq system and ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... , June 24, 2016  Arkis BioSciences, a ... invasive and more durable cerebrospinal fluid treatments, today ... The Series-A funding is led by Innova Memphis, ... and other private investors.  Arkis, new financing will ... and the market release of its in-licensed Endexo® ...
(Date:6/23/2016)... , June 23, 2016 Research ... Devices Global Market - Forecast to 2022" report to ... the treatment method for the patients with kidney failure, it ... excess fluid from the patient,s blood and thus the treatment ... potassium and chloride in balance. Increasing number ...
(Date:6/23/2016)... June 23, 2016 Research and ... Excipients Market by Type (Organic Chemical (Sugar, Petrochemical, Glycerin), ... Topical, Coating, Parenteral) - Global Forecast to 2021" ... The global pharmaceutical excipients market is projected ... CAGR of 6.1% in the forecast period 2016 to ...
Breaking Medicine Technology: