About 45 percent of recipients did experience side effects but these were typically mild and consisted of some soreness or redness at the injection site and/or a headache, the researchers reported.
For the second trial, British researchers led by Dr. Iain Stephenson of the Leicester Royal Infirmary tested the vaccine on 175 adults 18 to 50 years of age. Patients were randomly assigned to various two-dose regimens of the vaccine.
Those researchers also found that even a single dose of the vaccine was sufficient to protect adults from the H1N1 flu within the first two weeks after inoculation.
Both reports were published Sept. 10 in the online edition of the New England Journal of Medicine.
U.S. data to be released Friday will confirm those one-dose findings, and show that protection starts rapidly after vaccination, Dr. Anthony Fauci of the National Institutes of Health told the Associated Press.
"This is quite good news," Fauci said.
Dr. Marc Siegel, associate professor of medicine at New York University Langone Medical Center in New York City, said, "It looks like a single dose works -- wow."
"This is great news," Siegel said. "It looked like it was going to take two shots. But I am still expecting two shots [will be needed] in kids, because they don't have the immune basis," he noted.
In the United States, results from the first vaccine trials are expected later this month, and assuming the vaccine is safe and effective, it should begin to be available by mid-October, according to the Centers for Disease Control and Prevention.
In a third report in the same journal issue, researchers at the CDC found that this year's "regular" seasonal flu vaccine does not offer any protection against the H1N1 swine flu, regardless of the age of the patient. However, they did find that while people age 30 years or younger had little i
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