Navigation Links
NIH scientists unveil mechanisms of immune reconstitution inflammatory syndrome
Date:11/10/2010

WHAT: Newly published research by scientists at the National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health, sheds light on a poorly understood, acute illness called Immune Reconstitution Inflammatory Syndrome (IRIS) that develops in some HIV-infected individuals soon after they begin antiretroviral therapy.

IRIS affects certain HIV-infected individuals whose immune systems are heavily damaged by the virus and who have a treated or undiagnosed AIDS-associated infection. When these individuals start antiretroviral therapy and their immune cells begin to regenerate, the immune system unexpectedly produces an exaggerated response that unmasks or worsens the symptoms of the co-infection. IRIS has become a notable challenge in treating HIV disease, particularly in resource-limited settings. The scientists hope that better understanding how and why the syndrome occurs will lead to targeted prevention or therapy.

To find immunologic patterns that distinguish individuals who develop IRIS from those who do not, the researchers analyzed blood samples from HIV-infected individuals, focusing their analysis on a group of immune cells called T lymphocytes. Most of the studied patients had an AIDS-associated fungal, viral or bacterial infection before they started antiretroviral therapy.

The analysis showed that the individuals who developed IRIS had a higher proportion of activated T cells before starting antiretroviral therapy compared with those who did not develop IRIS. These activated T cells had the propensity to make a key infection-fighting molecule called interferon gamma both before therapy began and during IRIS episodes, suggesting that the cells may participate in the exaggerated immune response seen during IRIS. In addition, the surface markers expressed by the T cellssome with a stimulatory effect and some restraining in naturesuggested they were highly activated as a result of an encounter w
'/>"/>

Contact: Laura Sivitz Leifman
sivitzl@niaid.nih.gov
301-402-1663
NIH/National Institute of Allergy and Infectious Diseases
Source:Eurekalert

0

GOOD

Page: 1 2

Related medicine news :

1. Scientists Use Tarantulas to Explore Human Fear
2. Scientists Say Theyve Made Blood From Skin
3. Hospital for Special Surgery scientists share advances in lupus and related conditions
4. Scientists develop method to keep surgically-removed prostate tissue alive and working for week
5. Scientists turn a new leaf to discover a compound in daffodils that targets brain cancer
6. Scientists Report Early Success in Growing Mini Liver in Lab
7. Scientists seek urgent treatment for fatal sleeping sickness
8. Scientists investigate evolution of new polio virus
9. Scientists Raise Concerns About Flame Retardants
10. Scientists pinpoint gene linked to drug resistance in malaria
11. NIH scientists describe how salmonella bacteria spread in humans
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/19/2013)... The producers of Viewpoints TV ... The city is located in the center of what ... its frontier image and become an affordable city to live, ... city in the United States with a workforce strong in ... a low cost-of-living, friendly business environment and more than 100 ...
(Date:6/19/2013)... Chicago Niehoff School of Nursing researcher has received a ... can improve mood in women with diabetes who are ... D supplementation can reduce blood pressure and affect how ... the National Institute of Nursing Research at the National ... PhD, RN and colleagues hypothesize that women receiving vitamin ...
(Date:6/19/2013)... Chicago is cracking down on bed bugs. New ... will require landlords to exterminate any and all reported bed ... ordinance also makes tenants responsible for reporting signs of bed ... often include disposing of furniture, bedding, and more. , In ... did more bed bug business in Chicago than any other ...
(Date:6/19/2013)... Ethigen announced today the US launch ... , providing next-generation sequencing (NGS) and rearrangement analysis of ... of an expanded hereditary cancer panel, including full coverage ... to cancer risk: MLH1, MSH2, MSH6, APC, MUTYH (MYH), ... FLCN, PDGFRA, and KIT. , The expanded panel ...
(Date:6/19/2013)... Arem Wellness was developed and is ... Dr. Ridha Arem, who is determined to help educate ... goal, Arem Wellness provides a monthly newsletter, a blog, ... as well as an exceptional supplement line uniquely designed ... crucial role diet and nutrition have not only on ...
Breaking Medicine News(10 mins):Health News:Viewpoints TV Announces June Air Dates for Phoenix, AZ 2Health News:Loyola receives $1.5 million grant to study vitamin D for diabetes and depression 2Health News:Chicago Ordinance Requires Landlords and Tenants to Take Responsibility for Bed Bugs 2Health News:Ethigen Launches Next Generation (NGS) BRCA Testing With Expanded Hereditary Cancer Panel 2Health News:Ethigen Launches Next Generation (NGS) BRCA Testing With Expanded Hereditary Cancer Panel 3Health News:Arem Wellness Announces a Recipe Contest 2Health News:Arem Wellness Announces a Recipe Contest 3
... Ellis Island Medal of Honor, established by the National Ethnic ... Eapen, who will receive the award May 12, said he ... boost for all my future endeavours," Eapen told IANS on ... Honor are presented annually to US citizens of diverse origins ...
... higher levels of calcium and vitamin D are significantly more ... damage// that can increase risk of cognitive impairment, dementia, depression ... from Duke and the University of North Carolina examined magnetic ... men, 153 women) between the ages of 60 and 86 ...
... report that chicken are being fed contaminated feed is causing concern ... for the past few years//. The FDA is quick to play ... risk. ,This concern came to light after some 38 ... light that these farms fed the chicken for human consumption with ...
... researchers, diabetes is fast becoming a common reason for ... Medicine Research Group at Queen's University, Belfast, based their ... were diagnosed with Diabetes Type 1. In this ... produce the hormone insulin needed for various metabolic activities. ...
... decision to undergo breast enlargement surgery. But he carried this ... Town, east London, was found guilty of kidnapping his wife, ... was scheduled to undergo the surgery. ,Claiming ... McCarthy kidnapped his wife from the hospital where she was ...
... There is a definite link between pregnancy, migraine and ... a deadly one. ,In fact, Cheryl Bushnell, ... for Cerebrovascular Disease in Durham, explained that pregnant women ... times more than pregnant women who did not suffer ...
Cached Medicine News:Health News:Higher Intake of Calcium and Vitamin D Linked With Brain Lesions in Older People 2Health News:Tainted Pet Food a Health Risk for Human? 2Health News:Fertility Rates Felled By Diabetes 2
(Date:6/18/2013)... June 18, 2013  It has become apparent ... Seating and Mobility, a subsidiary company of The ... repair. This appears to be due to the ... field service employees.  (Logo: ... of these clients are complex mobility users with ...
(Date:6/18/2013)... N.C. , June 18, 2013  Recent regulatory ... difficult for Medical Education groups at large pharmaceutical companies ... the safe and effective use of their new products. ... pharma industry, it is crucial that these "Med ... healthcare professionals. To address the changes that ...
(Date:6/18/2013)... 2013 Unilife Corporation ("Unilife" or "Company") (NASDAQ: ... manufacturer of injectable drug delivery systems, today announced the ... . The new site includes additional products, videos, features, ... a regular basis. Mr. Alan Shortall ... global leader for injectable drug delivery systems, we have ...
Breaking Medicine Technology:Though Vital to Educating Doctors on New Products, Pharma "Med Ed" Groups Working Under Huge Internal & External Constraints 2Unilife Launches New Corporate Website 2
Sensitive Eyes drops keep soft contact lenses moist....
Lens Plus Sterile Saline Solution...
... Renu Multiplus No Rub formula is the ... today. All steps in one bottle without ... stores soft contact lenses and removes protein ... multi-purpose solution that contains Hydranate, a special ...
Sensitive Eyes sterile saline spray is the preservative-free aerosol saline solution for people with eyes sensitive to preservatives. Used for rinsing soft contact lenses after cleaning or thermal or...
Medicine Products: