Navigation Links
New therapies and gene target advance the treatment and understanding of hard-to-treat leukemias
Date:12/6/2010
induction chemotherapy alone does not produce prolonged remissions. Therefore, an allogeneic stem cell transplant, in which a patient receives stem cells from a sibling or unrelated matched donor, is often recommended after the first complete remission.
In 1993 researchers from the National Cancer Research Institute in the United Kingdom and the Eastern Cooperative Oncology Group in the United States initiated a study to evaluate whether allogeneic stem cell transplant is an effective treatment option for adult patients with Ph+ ALL. In this study, 266 patients received two phases of induction chemotherapy followed by an allogeneic stem cell transplant ("pre-imatinib" arm). Following the availability of imatinib, a targeted BCR-ABL inhibitor, the purpose of the study was modified in 2003 to include and evaluate the use of imatinib as part of consolidation therapy prior to an allogeneic stem cell transplant ("late-imatinib" arm) or as part of standard induction therapy prior to the transplant ("early-imatinib" arm). Results from the pre-imatinib cohort (Fielding, Blood 2009) were then used as a benchmark for use of imatinib in patients with Ph+ ALL.
In the late-imatinib arm of the study, 86 patients received imatinib 600 mg a day as part of consolidation therapy prior to undergoing an allogeneic stem cell transplant following two induction chemotherapy regimens. Those in the early-imatinib arm (89 patients) were given imatinib 600 mg earlier as part of the second chemotherapy induction phase prior to the allogeneic stem cell transplant. All patients who received an allogeneic stem cell transplant in the study were given imatinib for two years post-transplant. If a transplant was not feasible for any reason, imatinib could be given as a maintenance therapy for two years.
Results from this study, the largest international study of patients with Ph+ ALL evaluating allogeneic stem cell transplantation (control group) and the use of im
'/>"/>
| Contact: Lindsey Love llove@hematology.org 540-538-9326 American Society of Hematology Source:Eurekalert |
Related medicine news :
1. MSU researcher linking breast cancer patients with alternative therapies
2. Notch-blocking drugs kill brain cancer stem cells, yet multiple therapies may be needed
3. ReportsandReports : The Gastrointestinal Market Outlook to 2014: Market Dynamics, Competitive Landscape, Emerging Therapies
4. NIH/NHLBI-funded PACT Group Announces the Renewal of Production Assistance for Cellular Therapies (PACT)
5. ACCORD: Intensive BP, combined lipid therapies do not help adults with diabetes
6. Intense Cholesterol, Blood Pressure Therapies Dont Help Type 2 Diabetics
7. Study evaluates costs and benefits associated with new colon cancer therapies
8. New therapies increase survival rates in post-transplant liver cancer patients
9. Survival in metastatic breast cancer patients is improving: targeted therapies have contributed
10. Molecular discovery points to new therapies for brain tumors
11. Ovarian cancer study offers vital clues for new therapies
Post Your Comments:
(Date:5/24/2013)... 24, 2013 http://www.resource4thepeople.com/defectivedrugs/Zithromax-lawsuits.html ... latest update involving allegations that the use of ... can allegedly cause potentially fatal irregular heart ... May 17, 2013* that Health Canada has joined ... that Zithromax can cause abnormal changes in the ...
(Date:5/24/2013)... (PRWEB) May 24, 2013 The leading retail ... discount offer on short prom dresses . Now that ... that is standard with the brand name since its origin. ... in prom dresses. And now this huge discount offer will ... “I feel highly privileged to announce that Short ...
(Date:5/23/2013)... Maui, HI (PRWEB) May 23, 2013 Magic ... comic book describing the exploits of precocious twin five-year olds, ... Maui , is just such a case in point. May ... Maui” and is timed to coincide with the start ... travel experience combining family adventures, tons of amenities and, most ...
(Date:5/23/2013)... 2013 In his pulse-quickening novel, “The AIDS ... “Do you trust your government?” , In the “The AIDS ... route to London ’s Heathrow Airport. His American colleague, ... waiting for him to arrive at his Sierra Nevada ... Alan has doubts about the government’s report. When Alan learns ...
(Date:5/23/2013)... 23, 2013 Dr. Damon Huffman of Huffman ... from gum disease a revolutionary new treatment method with the ... of Americans who suffer from periodontal disease, and many of ... Dr. Huffman is hoping that LANAP will encourage many ... , Periodontal disease can cause gums to ...
Breaking Medicine News(10 mins):Health News:2013 Alleged Zithromax Arrhythmia and Sudden Death Cases Update: Canadian Health Officials Issue Warning 2Health News:2013 Alleged Zithromax Arrhythmia and Sudden Death Cases Update: Canadian Health Officials Issue Warning 3Health News:2013 Alleged Zithromax Arrhythmia and Sudden Death Cases Update: Canadian Health Officials Issue Warning 4Health News:short prom dresses Offers Abnormally Low Discount on Its New Collections 2Health News:New Children's Comic Book, "Howie Goes to Maui," Launches May 23, 2013 On Four Seasons Resort Maui's Web Site 2Health News:New Children's Comic Book, "Howie Goes to Maui," Launches May 23, 2013 On Four Seasons Resort Maui's Web Site 3Health News:New Book “The AIDS Covenant” by Roy Harris Delivers Intriguing, Captivating Story 2Health News:Humble, TX Dentist, Dr. Damon Huffman Now Offers Laser Periodontal Disease Treatment to Gum Disease Patients 2[0] 2013 Alleged Zithromax Arrhythmia and Sudden Death Cases Update: Canadian Health Officials Issue Warning[0] short prom dresses Offers Abnormally Low Discount on Its New Collections[0] New Children's Comic Book, "Howie Goes to Maui," Launches May 23, 2013 On Four Seasons Resort Maui's Web Site[0] New Book “The AIDS Covenant” by Roy Harris Delivers Intriguing, Captivating Story[0] Humble, TX Dentist, Dr. Damon Huffman Now Offers Laser Periodontal Disease Treatment to Gum Disease Patients
... SCHAUMBURG, Ill. , Jan. 20 The American ... joined a coalition of other animal health and welfare groups to ... following the January 12 earthquake that devastated the country. ... was developed by the International Fund for Animal Welfare (IFAW) and ...
... found that acyclovir, a drug widely used as a safe ... virus-2 (HSV-2), which is the most common cause of genital ... taken by people infected with both HIV and HSV-2. ... New England Journal of Medicine online today, and will ...
... NJ A new brain-based computational model is ... medicationsused to treat motor symptoms caused by the ... reported in a forthcoming article in the ... a new computational model, developed by Drs. Ahmed ...
... injections could boost treatment, experts say, but safety concerns ... new drugs -- both oral, rather than injected -- may ... all being published early online Jan. 20 in the ... drugs -- fingolimod and cladribine -- reduce relapse rates in ...
... , Jan. 20 Family Research Council ( ... the following statement regarding the Massachusetts Senate election results: ... to be in the left-hand column into eternity, the results of ... visit to the Bay State made it clear that ...
... recent years, there has been a large increase in the ... approximately 51% of non-pregnant women ages 20 to 39 being ... in the journal Nursing for Women,s Health finds ... birth defects, as well as a greater risk of childhood ...
Cached Medicine News:Health News:U.S. Veterinarians Join Coalition to Help Haiti 2Health News:U.S. Veterinarians Join Coalition to Help Haiti 3Health News:Herpes medication does not reduce risk of HIV transmission, UW-led international study finds 2Health News:Herpes medication does not reduce risk of HIV transmission, UW-led international study finds 3Health News:Herpes medication does not reduce risk of HIV transmission, UW-led international study finds 4Health News:A novel computational model -- how Parkinson's medications affect learning and attention 2Health News:First Oral Medications For MS Show Promise 2Health News:First Oral Medications For MS Show Promise 3Health News:FRC: Mass Election Results a Near Revolutionary Rejection of President Obama's Leftist Agenda 2Health News:Pregnant women who are overweight put their infants at risk 2U.S. Veterinarians Join Coalition to Help HaitiHerpes medication does not reduce risk of HIV transmission, UW-led international study findsA novel computational model -- how Parkinson's medications affect learning and attentionFirst Oral Medications For MS Show PromiseFRC: Mass Election Results a Near Revolutionary Rejection of President Obama's Leftist AgendaPregnant women who are overweight put their infants at risk
(Date:5/23/2013)... , May 23, 2013 Haemonetics Corporation (NYSE: ... , CFO & EVP-Business Development, will present at The ... in Boston, MA on May 29, ... http://photos.prnewswire.com/prnh/20120206/NE47232LOGO ) The public may access Mr. ... About Haemonetics Haemonetics (NYSE: ...
(Date:5/23/2013)... KNOXVILLE, Tenn. , May 23, 2013 /PRNewswire/ ... of 24-hour nurse triage and nurse advice lines, ... 10-person committee, comprising physician, nursing and administrative leaders, ... providing safe, quality and cost-effective services for hospital ... "As our national healthcare system evolves, it,s imperative ...
(Date:5/23/2013)... Every day, their baby stopped breathing, his collapsed bronchus ... April and Bryan Gionfriddo watched helplessly, just ... "Quite a few doctors said he had a good chance ... Gionfriddo , about her now 20-month-old son, Kaiba. "At ... would take it and run with it." They ...
Breaking Medicine Technology:TeamHealth Medical Call Center Forms Clinical Advisory Committee 2Baby's life saved with groundbreaking 3D printed device from U-M that restored his breathing 2Baby's life saved with groundbreaking 3D printed device from U-M that restored his breathing 3Baby's life saved with groundbreaking 3D printed device from U-M that restored his breathing 4... , , , , ... , THE WOODLANDS, Texas, July 21 ... biopharmaceutical company focused on discovering and developing breakthrough treatments for human disease, ... for Orphan Medical Products (COMP) of the European Medicines Agency (EMEA) for ...
... , TOKYO, July 21 R-Tech Ueno, Ltd. ... on the new compound RK-023 that is being developed by our ... see the note below) has been completed. , ... of a patch test (open, closed, photo-patch test), single-dose study and ...
Cached Medicine Technology:Lexicon's Drug Candidate LX1032 for Carcinoid Syndrome Receives Orphan Drug Designation From EMEA 2Lexicon's Drug Candidate LX1032 for Carcinoid Syndrome Receives Orphan Drug Designation From EMEA 3Lexicon's Drug Candidate LX1032 for Carcinoid Syndrome Receives Orphan Drug Designation From EMEA 4R-Tech Ueno, Ltd. Completes Phase 1 Clinical Study on RK-023 2R-Tech Ueno, Ltd. Completes Phase 1 Clinical Study on RK-023 3Arthroscopic instrument system for instability and SLAP fixation....
The Charlotte Shoulder™ System address arthroscopic, mini-open and open procedures with time saving instrumentation....
Arthroscopic instrument system for instability and SLAP fixation....
Suture Cutter, straight...
Medicine Products:| Copyright © 2003-2012 Bio-Medicine. All rights reserved. ABOUT | CONTACT US | DISCLAIMER | PRIVACY POLICY | TERMS AND CONDITIONS |  |