New technology to tackle treatment-resista... (ients with pancreatic cancer. The au...)

New technology to tackle treatment-resistant cancers

Date:2/3/2012

ients with pancreatic cancer.

The authors also report that their test showed significantly better results when compared with the commercial test, CellSearch, which uses a slightly less accurate approach which effectively reduces the sample from approximately 50 million cells to just 5,000 before conducting fluorescent imaging, meaning important cells you wish to study could be lost.

In 7.5 mL of blood, the CellSearch test found two or more CTCs in 5 out of the 15 patients tested whereas the new test found two or more CTCs in a single milliliter of blood in 14 out of the 15 patients tested.

The dyes used in this new approach contain antibodies that target, and then attach to, specific proteins that are expressed by the CTCs. Once attached, they fluoresce and allow the researchers to observe them. The result is a set of high resolution digital images that retain the intricate details of the cells and allow the researchers to effectively analyse them in the laboratory. Also striking is the quality of the images.

"The high definition method gives a detailed portrait of these elusive cells that are caught in the act of spreading around the body. It's unprecedented we've never been able to see them routinely and in high definition like this before," says diagnostic pathologist Kelly Bethel, MD, the senior clinical investigator on Kuhn's team.

"The science behind this approach, and the ability to obtain more detailed information about CTCs in a timely fashion, opens up opportunities to address some of the outstanding problems in cancer, such as drug-resistance. This is an example that bringing a physical sciences approach to a medical need has potential for profound consequences to greatly benefit cancer patients," said Dr Larry Nagahara of the National Cancer Institute.

Contact: Michael Bishop
michael.bishop@iop.org
01-179-301-032
Institute of Physics
Source:Eurekalert

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