Navigation Links
New combo lung cancer therapy improves survival over single-line treatment
Date:12/15/2010

nhibitors such as erlotinib. In this study, the combination of erlotinib and the HDAC inhibitor entinostat lead to a small but not statistically significant improvement in survival in unselected patients but a large and statistically significant improvement in survival in patients with high expression of Ecadherin ( 9.4 months vs.5.4 months). While extremely promising, these results will need to be confirmed in a larger randomized phase III trial."

"Using a biomarker to select patients based on the tumor biology can improve patient outcomes versus treating an unselected patient population," said University of Colorado Cancer Center researcher Fred Hirsch, MD, PhD, professor of medical oncology at the CU medical school.

Data from the phase 2 trial, led by Robert Jotte, MD, PhD, of Denver's Rocky Mountain Cancer Center, was presented recently at the ASTRO 2010 Chicago Multidisciplinary Symposium in Thoracic Oncology, co-sponsored by the American Society for Radiation Oncology, the American Society of Clinical Oncology, the International Association for the Study of Lung Cancer and The University of Chicago.

"The data presented suggest that NSCLC patients with elevated E-cadherin levels can do better when treated with entinostat and erlotinib," said Joanna Horobin, MD, president and chief executive officer of Syndax, the company that holds worldwide rights to entinostat.

Syndax holds rights to the CU intellectual property related to this type of combination therapy which includes the use of E-cadherin to predict responsiveness to the therapy.

"Syndax has been a model commercial partner for the University, and we are both encouraged and excited by the Phase 2 results," said David Poticha, senior licensing manager at the CU Technology Transfer Office.


'/>"/>

Contact: Lindsay Lennox
lindsay.lennox@cu.edu
303-735-5518
University of Colorado Denver
Source:Eurekalert

0

GOOD

Page: 1 2

Related medicine news :

1. Exercise Combo Best for Type 2 Diabetes
2. Binge Drinking, Hypertension a Deadly Combo
3. Drug Combo Staves Off Type 2 Diabetes
4. Bone Marrow Cancer Patients May Benefit From Drug Combo
5. Short-Term Drug Combo May Help Prevent Colon Cancer
6. Novel therapy for metastatic kidney cancer developed at VCU Massey Cancer Center
7. Nanoscale gene ignition switch may help spot and treat cancer
8. Gene Research Sheds Light on Lung Cancer Survival Time
9. UNC scientists discover potential strategy to improve cancer vaccines
10. Breast inflammation is key to cancer growth, Kimmel Cancer Center researchers say
11. Gene information predicts survival time, possible new treatment options for lung-cancer patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/25/2013)... Communities of Distinction TV announces ... fifth largest media market in the United States with almost ... destination in Texas and a major convention city. Ft. Worth ... as it is home to many major museums. Both cities ... to the arts. Residents and locals will be able to ...
(Date:5/25/2013)... 25, 2013 The report “Global ... Types, Functions, Applications, Ingredients, Shell Materials, Packaging, & ... global food encapsulation market with analysis and forecasting ... also identifies the driving and restraining factors for ... trends, opportunities, and challenges. The market is segmented ...
(Date:5/25/2013)... 2013 On May 20, 2013 the ... wish to discuss or plan for their eventual demise, but ... released a Must-Do List to help people properly arrange ... “Creating a personal fact sheet.” , While not a formal ... and personal data. It may include a summary of ...
(Date:5/25/2013)... According to a new market ... published by MarketsandMarkets is expected to reach $544.02 ... which analyzes and studies the major market drivers, ... and Rest of the World. , Browse:, ... 87 Figures , 175 ...
(Date:5/25/2013)... 2013 The Slim Weight Patch has been ... This is due to the highly sought after ingredients that ... patch offers an extra 2 months supply & premium membership ... get the body you desire faster than ever. , ... , With Slim weight patch consumers can observe instant results ...
Breaking Medicine News(10 mins):Health News:Communities of Distinction TV Presents May Air Dates for Dallas-Ft. Worth, Texas 2Health News:Food Encapsulation Market to Reach $42 Billion by 2016 - New Report by MarketsandMarkets 2Health News:Food Encapsulation Market to Reach $42 Billion by 2016 - New Report by MarketsandMarkets 3Health News:FuneralFinancials.com Releases Last Wishes Must-Do List 2Health News:Homeland Security Market to Reach $544.02 Billion by 2018 at a CARC of 5.54% - New Report by MarketsandMarkets 2Health News:Homeland Security Market to Reach $544.02 Billion by 2018 at a CARC of 5.54% - New Report by MarketsandMarkets 3Health News:Homeland Security Market to Reach $544.02 Billion by 2018 at a CARC of 5.54% - New Report by MarketsandMarkets 4Health News:Slim Weight Patch Advanced Weight Loss System Offers Extra Two Month Supply and Membership for Maximum Weight Loss 2
... PARK, Ill., Nov. 12 Abbott (NYSE: ABT ) ... to PanGenetics BV,s PG110 fully humanized antibody to Nerve Growth ... its expertise in biologics. PG110 is a novel biologic in ... treatment of chronic pain. NGF is released at sites of ...
... in lab study , THURSDAY, Nov. 12 (HealthDay News) -- ... promise as a possible treatment for ovarian cancer, new research ... treat chronic myeloid leukemia. Researchers at the University of California ... and invasive powers of ovarian cancer cells. , It ...
... ... Class Action/Mass Torts session discussing tainted food products , ... San Francisco, CA (PRWEB) November 12, 2009 -- Mary Alexander Esq., ... nation, will take the podium during the 48th Annual Consumer Attorneys of California (CAOC) Convention. ...
... ... Medical Officer of Stemedica Cell Technologies, Inc. was invited to lecture at a ... constituent college of the University of Oxford, England. The seminar, which focused ... than 300 professors and staff representing all facets of the University. , ...
... Texas ... the peak-season flavors of Texas citrus and pecans. Packed with healthy ingredients, this Italian-inspired, twice-baked ... not just for yourself, but everyone on your gift list. , ... Dallas, TX (PRWEB) November 11, 2009 -- Looking for ...
... ... Management and Supply Chain Forecasting Tool Honored for Technological Excellence , ... Birmingham, Ala. (PRWEB) November 12, 2009 ... that it has earned Cardinal Health,s Innovation Award. This prestigious honor recognizes SourceMedical ...
Cached Medicine News:Health News:Abbott to Acquire Novel Investigational Biologic to Treat Chronic Pain 2Health News:Leukemia Drug May Help Some Ovarian Cancer Patients 2Health News:California Consumer Attorney Mary Alexander to Present at 48th Annual COAC Convention 2Health News:Stemedica President Invited To Lecture At The University Of Oxford 2Health News:Stemedica President Invited To Lecture At The University Of Oxford 3Health News:Dip into a Healthy Holiday with the Taste of Texas Oncology's Holly Jolly Biscotti 2Health News:Dip into a Healthy Holiday with the Taste of Texas Oncology's Holly Jolly Biscotti 3Health News:Dip into a Healthy Holiday with the Taste of Texas Oncology's Holly Jolly Biscotti 4Health News:SourceMedical Earns Cardinal Health Innovation Award 2
(Date:5/24/2013)... , May 24, 2013  An international roster ... Saturday, May 18, in Santa Monica, Calif. ... new lung-sparing therapies for MPM, a rare form of ... affects the pleura, the lining of the chest. ... and Blood Institute, the 3rd Annual International Symposium on ...
(Date:5/24/2013)... 2013  Auxilium Pharmaceuticals, Inc. (Nasdaq: AUXL ... the Deutsche Bank Health Care Conference to be held ... Adrian Adams , Chief Executive Officer ... the Company and its product pipeline at 12:00 p.m. ... (Logo: http://photos.prnewswire.com/prnh/20101202/MM10881LOGO ) The presentation will ...
(Date:5/24/2013)... The potential of the pulmonary route as ... has been receiving undeniable attention with the recent advances ... crucial formulation considerations for orally inhaled products together with ... in the efficiency of pulmonary delivery, and great strides ... techniques and devices in recent years. With ...
Breaking Medicine Technology:International Mesothelioma Experts Present Promising New Research Findings at the 3rd Annual International Symposium on Lung-Sparing Therapies for Malignant Pleural Mesothelioma 2International Mesothelioma Experts Present Promising New Research Findings at the 3rd Annual International Symposium on Lung-Sparing Therapies for Malignant Pleural Mesothelioma 3Auxilium Pharmaceuticals, Inc. To Present At The Deutsche Bank Health Care Conference 2Auxilium Pharmaceuticals, Inc. To Present At The Deutsche Bank Health Care Conference 3Auxilium Pharmaceuticals, Inc. To Present At The Deutsche Bank Health Care Conference 4Inhalaltion Drug Delivery: 11-12 September - Berlin, Germany 2
... and cesarean section trials in conjunction with David ... G. Genecov, MD, FACS, FAAP to begin immediately, ... BIEL), the maker of the ActiPatch(TM), a drug free ... pulse therapy specifically designed to speed healing, today,announced world ...
... CARMEL, Israel, May 28 , - Study ... Non-Invasive,MRgFUS to Those who had Invasive Fibroid Surgery, ... Food and Drug,Administration (FDA) cleared the company to ... safety of the ExAblate(R) 2000 system utilizing,MR-guided Focused ...
Cached Medicine Technology:BioElectronics Announces Major Clinical Trials 2BioElectronics Announces Major Clinical Trials 3BioElectronics Announces Major Clinical Trials 4FDA Clears ExAblate Fertility Enhancement Study in Women With Uterine Fibroids 2FDA Clears ExAblate Fertility Enhancement Study in Women With Uterine Fibroids 3FDA Clears ExAblate Fertility Enhancement Study in Women With Uterine Fibroids 4
Stability cemented stem....
Cemented foundation 460 series....
The Opteon stem meets the challenge of providing a high-quality, cost-effective hip implant for the moderate demand patient....
A cementless femoral stem that promotes bone in-growth and reduces thigh pain....
Medicine Products: