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New combination effective against pancreatic cancer
Date:6/15/2010

ct of sorafenib

There are naturally occurring substances that block precisely this undesired NF-KB pathway and thus make the dangerous cells vulnerable: vegetables from the cruciferous family such as broccoli and cauliflower possess a high content of sulforaphane, an anti-cancer compound. The experiments show that sulforaphane prevents the activation of the NF-KB pathway by sorafenib. The combination treatment reinforces the effect of sorafenib without causing additional side effects. The invasive potential of cancer cells was prevented metastasis was completely blocked in cell culture experiments. "We assume that nutrition may be a suited approach to break therapy resistance of cancer stem cells and thus make tumor treatment more effective," Professor Herr suggested.


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Contact: Dr. Ingrid Herr
i.herr@dkfz.de
062-215-637-123
University Hospital Heidelberg
Source:Eurekalert

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