New biomarker predicts response to hepatitis C... (ith the favorable (CC) genotype had a si...)

New biomarker predicts response to hepatitis C treatment

Date:8/16/2009

ith the favorable (CC) genotype had a significantly higher rate of response to treatment (53.3 percent) than did individuals of European ancestry who had the less favorable (TT) genotype (33.3 percent).

The researchers also ran tests to see if the presence of the biomarker was related in any way to viral load, a measure of how much virus was circulating in the patient before treatment started. They found a significant association in all groups. "Interestingly, we found that the C allele, although associated with better treatment response, was associated with a higher viral load at baseline something we have traditionally viewed as a negative prognostic marker when it comes to treatment response," says McHutchison.

That finding, along with other evidence gleaned in the research, suggests that patients who have the beneficial genetic marker might be especially adept at spontaneously clearing the virus through some as yet unknown mechanism, says McHutchison. "It was thrilling to discover such an important biological marker related to response to hepatitis C treatments, but at the same time, the findings tell us there is a lot more work to do before we can fully understand how patients' immune systems protect them from the virus."

"This stunning finding supports the integration of research efforts that previously were not connected," says Robert Califf, M.D., vice chancellor for clinical research and director of the Duke Translational Medicine Institute. "Drs. Goldstein, McHutchison and colleagues have combined world class genotyping and clinical trials management in an academic medical center with an industry sponsored clinical trial to produce a set of findings that are likely to change practice. Their focus on modification of clinical outcomes is especially important to note as we design future studies."

Some members of the research team are interested in finding a way to routinely test for the new marker, but McHutchison say
'/>"/>

Contact: Michelle Gailiun
michelle.gailiun@duke.edu
919-660-1306
Duke University Medical Center
Source:Eurekalert

2

GOOD

Page: 1 2 3 4
Related medicine news :

1. First biomarker discovered that predicts prostate cancer outcome
2. Penn School of Medicine receives $2.3 million to study biomarkers of cigarette smoke exposure
3. Study makes progress in zoning in on biomarkers for better colon cancer treatment
4. New Ovarian Cancer Biomarker Research Act Introduced
5. Mayo Clinic study points to a possible biomarker for colon cancer in people 50 and under
6. Singulex Announces Presentation on Monitoring of Cardiac Biomarker to Assess Transient Myocardial Ischemia at the American Heart Association Scientific Sessions
7. Biomarker may be an early predictor of advanced breast cancer
8. Millennium Announces MLN1202 Significantly Reduced Marker of Systemic Inflammation and Identifies Genomic Biomarker For Responders
9. Biomarkers predict risk for invasive breast cancer years before the tumor develops
10. JDRF and Lilly partner to fund research to identify beta cell biomarkers
11. Biomarkers for Alzheimers disease can be trusted in clinical trials

Post Your Comments:

(Date:5/22/2013)... 2013 Athletic-Minded Traveler LLC, a ... released today its 2013 U.S. Business Hotel “Fit ... the company’s recommendation after ongoing research of over ... by the editorial staff. Selection criteria included ... court, etc.), in-room workout choices, healthy food offerings, ...

(Date:5/21/2013)... Swimsuit season is almost here. The "Get ... has begun with a 35% discount. , Cellulite forms mainly ... get the dreaded cellulite even if they are in shape. ... they have been stored as toxic lymph and smashed together, ... a specific program that works to dissolve the toxins and ...

(Date:5/21/2013)... 2013)Today the George Washington (GW) University School ... announced the launch of the Avance Center ... collaboration between SPHHS, the Maryland Multicultural Youth ... partners. This university-community partnership aims to address ... communities through research, mutual capacity building and ...

(Date:5/21/2013)... 2013 DISCcert has served the training ... use 17 DISC applications at the July 25 & ... , The July 25 & 26th DISC certification in ... of applying DISC. The time-tested, proven support materials will ... DISC training materials ; worksheets, handouts, learning ...

(Date:5/21/2013)... (PRWEB) May 21, 2013 ContinuCare Home ... Texas Department of Aging and Disability Services. After completing ... employee interviews, ContinuCare Home Health was found to ... review is part of the Department of Aging and ... aging and disability services, supports and opportunities that ...

Breaking Medicine News(10 mins):Health News:2013: The 10 Healthiest Business Hotels in the U.S. 2 Health News:Diminish Cellulite for Swimsuit Season; Sublime Beauty Introduces Cellulite Whisperer® Products in the "Get Ready for Summer Sale" 2 Health News:GW launches center to address health disparities in the Latino immigrant community 2 Health News:GW launches center to address health disparities in the Latino immigrant community 3 Health News:DISCcert Offers 17 Applications in Coming DISC Certification 2 Health News:DISCcert Offers 17 Applications in Coming DISC Certification 3 Health News:DISCcert Offers 17 Applications in Coming DISC Certification 4 Health News:ContinuCare Home Health, Inc. Receives Perfect Report from the Texas Department of Aging and Disability Services 2

[0] 2013: The 10 Healthiest Business Hotels in the U.S.[0] Diminish Cellulite for Swimsuit Season; Sublime Beauty Introduces Cellulite Whisperer® Products in the "Get Ready for Summer Sale"[0] GW launches center to address health disparities in the Latino immigrant community [0] DISCcert Offers 17 Applications in Coming DISC Certification [0] ContinuCare Home Health, Inc. Receives Perfect Report from the Texas Department of Aging and Disability Services

... (Nasdaq: CYNO ), a leading developer and ... systems, today announced financial results for the three and ... Results Consistent with Cynosure,s January 15, 2009 announcement, ... were $25.5 million, reflecting the effect of deteriorating global ...

... Feb. 10 Novasys Medical, Inc., a developer of ... one of the nation,s leading health insurers with over ... treatment for stress urinary incontinence (SUI) in non-pregnant women ... undergo surgery for their condition. According to Aetna,s updated ...

... Kit Offers Extensive Enrollment Information and Insights into ... Feb. 10 HealthLeaders-InterStudy , a leading ... District Survival Kit designed to provide pharmaceutical sales ... and analysis that drives innovative sales strategy development.Each ...

... quarter decline in procedure volume rate shows signs of ... 48% Provides near-term financial outlook CINCINNATI, Feb. 10 ... LCAV ), a leading provider of laser vision correction ... financial and operating results for the three and 12 ...

... OSF HealthCare and Seattle Children,s Hospital among the ... software suiteCLEVELAND, Feb. 10 Healthcare organizations ... healthy lifestyle. Now, hospitals and health systems are ... preaching. Paper medical records cause costly errors, potentially ...

... AHPI ) reported that its net income for ... or zero cents per share in the,prior year period, to ... per,share, primarily because of lower sales volume in the current ... the second quarter fell about 8 percent, or almost $1.1,million, ...

Cynosure Reports Financial Results for the Fourth Quarter and Full Year 2008 Aetna Now Covers Novasys Medical's Renessa(R) Treatment for Incontinence in Women HealthLeaders-InterStudy Offers District Survival Kit to Arm Pharmaceutical Sales Teams With Local-Level Managed Care Market Intelligence LCA-Vision Announces Fourth Quarter and Full Year 2008 Financial Results OnBase is the Choice for a Growing Number of Healthcare Organizations Allied Healthcare Reports Second Quarter Loss

(Date:5/22/2013)... Calif. , May 22, 2013 Rigel ... the clinical advancement of three programs in development. The ... a JAK/SYK inhibitor, R348, being developed by Rigel as ... programs are aimed at oncology targets and are being ... under development by BerGenBio AS (BerGenBio) and a ligase ...

(Date:5/22/2013)... , May 22, 2013 Assured Pharmacy, Inc. ... prescription medications to sufferers of chronic pain, announced it ... national investor relations firm, to raise its visibility and ... "Over the past year, we have proven our business ... announced plans to open two additional new pharmacies in ...

(Date:5/22/2013)... WomanCare Global recently launched Simplant in ... training initiative attended by 90 health care providers. ... http://photos.prnewswire.com/prnh/20101018/DC83896LOGO ) Simplant, a long-acting ... subdermal implant composed of two thin, flexible, silicone ... form of the hormone progestin). These are inserted ...

Breaking Medicine Technology:Rigel's R348 to Initiate Phase 2 Clinical Trial in Dry Eye 2 Rigel's R348 to Initiate Phase 2 Clinical Trial in Dry Eye 3 Rigel's R348 to Initiate Phase 2 Clinical Trial in Dry Eye 4 Assured Pharmacy Hires Hayden IR 2 Assured Pharmacy Hires Hayden IR 3 WomanCare Global launches Simplant, Long-acting Reversible Contraception, in Chile 2

[0] Rigel's R348 to Initiate Phase 2 Clinical Trial in Dry Eye [0] Assured Pharmacy Hires Hayden IR [0] WomanCare Global launches Simplant, Long-acting Reversible Contraception, in Chile

... 7, 2011 Talyst announces AutoPharm® Mobile, an ... The mobile application can be conveniently accessed on ... efficiency and control across the health system. ... to have real-time access to medication inventory throughout ...

... NEW YORK, Dec. 7, 2011 Reportlinker.com ... is available in its catalogue: ... http://www.reportlinker.com/p098411/Global-Microscopes-Industry.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=Medical_I This report ... US$ Million by the following Product Segments: ...

Cached Medicine Technology:Talyst Releases AutoPharm Mobile 2 Global Microscopes Industry 2

Talyst Releases AutoPharm Mobile Global Microscopes Industry

... gas permeable contact lenses used for corneal ... nearsightedness (myopia). The patient wears the lenses ... wakening. During the day, nearsightedness is corrected ... Quadra RG contact lenses apply slight pressure ...

... all the major challenges to operating ... fair market fee for each procedure ... licensure requirements., Board Certified Nuclear Medicine ... camera., Hot Lab Equipment and Accessories., ...

... ,Type 330 ,Straight, ,Konan realized an ... illumination between lenses for observation. This ... in ophthalmology and otorhinolaryngology, ,Konan offers ... can; an advanced zoom function (1:3) ...

... and most experienced provider of mobile catheterization ... States. Mobile laboratories serving hospital networks are ... one hospital to another in a particular ... laboratory is fully equipped and operated by ...

Medicine Products:

Paragon Quadra RG (paflufocon B)Nuclear Cardiology Facility Planning Services Operation Microscope Mobile Catheterization Laboratories Serving Hospital Networks