New 3-D imaging techniques for improved lung cancer drug d... (ifferences The current procedure ra...)

New 3-D imaging techniques for improved lung cancer drug development

Date:7/7/2010

ifferences

The current procedure radiologists use to measure changes to tumor size, called Response Evaluation Criteria in Solid Tumors (RECIST), can reliably detect a change only in volume greater than approximately 70 percent. To track how a tumor responds to treatment, doctors compare CT scans taken months apart and look to see if the maximum diameter of its cross-section has shrunk.

Recent studies have explored a more sensitive image measurement technique that could reduce this time by providing more detail: volumetric CT scanning, which images the tumor at high resolution in order to permit automated calculation of its 3-D volume. Emerging evidence suggests that "volumetric" measurements of lung nodule size could provide a better way to image a tumor by accounting for its shape and factoring out irregularities in its growth.

Zachary Levine of the National Institute of Standards and Technology (NIST) in Gaithersburg, Md., and his colleagues believe that 3-D volumetric approaches can detect smaller changes in tumor size, and they report the data to back up this claim in their Optics Express paper.

Levine and his team fabricated, and then scanned, 314 round objects with systematic variations in size and shape, creating 3-D images built of "voxels" used to calculate its volume. Each object's surface was also measured mechanically on a Coordinate Measuring Machine in NIST's Precision Engineering Division. Their results suggest that the volumetric approach could reliably detect a 5 percent difference in volumeat least in this idealized setup.

"On simple objects, we're showing that there is about a factor of 10 less variability associated with the measurement process," says Levine. Though he has no clinical data, Levine suspects that size changes of 20 percent could be realistically detected in actual lung nodules in the body.

This sensitivity, he hopes, could potentially speed up the drug trials on cance
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Contact: Angela Stark
astark@osa.org
202-416-1443
Optical Society of America
Source:Eurekalert

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